Howard Hughes Medical Institute (HHMI)
Research Technician - Brown Lab
Howard Hughes Medical Institute (HHMI), New York, New York, us, 10261
About the Role:
The Brown Laboratory (www.thebrownlaboratory.com) is seeking a highly motivated and detail-oriented Research Technician to support our cutting-edge research in immune regulation. The lab investigates mechanisms of immune tolerance across host–microbiota interactions, autoimmunity, cancer, and early-life immune development. Recent work from the lab has defined the cell types and mechanisms that instruct peripheral regulatory T cell development and tolerance to the gut microbiota.
Led by physician–scientist Dr. Chrysothemis Brown, the lab bridges mechanistic studies in experimental models with translational human immunology, collaborating closely with Memorial Sloan Kettering Cancer Center (MSK) and the Hospital for Special Surgery. The Brown Lab is located in the state-of-the-art Zuckerman Research Center on the Tri-Institutional campus (MSK, Weill Cornell, and Rockefeller University) in New York City’s Upper East Side—an exceptional environment for scientific growth, collaboration, and career development.
This position is ideal for candidates who are interested in working 2 years prior to pursuing graduate or medical school, offering a unique opportunity to gain hands‑on experience and mentorship in a leading immunology lab.
Application Instructions: Please include—preferably as a single PDF:
Cover letter describing your research interests and goals
CV (including relevant technical skills and any publications)
Names and contact information for at least two references
What You’ll Get
Comprehensive Training
in advanced techniques, including in vivo mouse handling, tissue processing, and high-dimensional flow cytometry
Close Mentorship
from senior lab members, with opportunities for skill development and project ownership
Preparation for Graduate or Medical School , including career guidance and research experience in a world-class biomedical environment
Publications and Authorship Opportunities , including potential for co-first author contributions
Exposure to Translational Research
through collaborations with clinical teams at MSK and HSS
Collaborative, Supportive Environment
that values teamwork, communication, and scientific curiosity
What You Will Do
Conduct experiments using in vivo mouse models, including animal handling, dissections, and tissue processing
Manage mouse colonies, including breeding and genotyping
Perform immune phenotyping via high-dimensional flow cytometry
Prepare samples for single-cell genomics workflows (scRNA‑seq / scATAC‑seq)
Carry out molecular biology and microbiology experiments (e.g., bacterial cultures, genome editing)
Maintain accurate records and protocols using an electronic lab notebook
Collaborate closely with team members, contribute to lab meetings, and assist in training new members
What You Bring
Bachelor’s degree in Biological Sciences, Biochemistry, Immunology, Microbiology, Molecular Biology, Genetics, or a related field
Required: Experience with animal handling and mouse colony management
Highly Preferred: Hands‑on experience with flow cytometry and animal dissection / tissue processing
Strong organizational and time‑management skills with the ability to thrive in a fast‑paced lab environment
Excellent communication skills and a team‑oriented mindset — enjoys collaborating and contributing to shared goals
Genuine enthusiasm for science, curiosity, and a desire to learn new techniques
Physical Requirements Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances or other hazardous materials.
Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.
Please Note: This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.
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Led by physician–scientist Dr. Chrysothemis Brown, the lab bridges mechanistic studies in experimental models with translational human immunology, collaborating closely with Memorial Sloan Kettering Cancer Center (MSK) and the Hospital for Special Surgery. The Brown Lab is located in the state-of-the-art Zuckerman Research Center on the Tri-Institutional campus (MSK, Weill Cornell, and Rockefeller University) in New York City’s Upper East Side—an exceptional environment for scientific growth, collaboration, and career development.
This position is ideal for candidates who are interested in working 2 years prior to pursuing graduate or medical school, offering a unique opportunity to gain hands‑on experience and mentorship in a leading immunology lab.
Application Instructions: Please include—preferably as a single PDF:
Cover letter describing your research interests and goals
CV (including relevant technical skills and any publications)
Names and contact information for at least two references
What You’ll Get
Comprehensive Training
in advanced techniques, including in vivo mouse handling, tissue processing, and high-dimensional flow cytometry
Close Mentorship
from senior lab members, with opportunities for skill development and project ownership
Preparation for Graduate or Medical School , including career guidance and research experience in a world-class biomedical environment
Publications and Authorship Opportunities , including potential for co-first author contributions
Exposure to Translational Research
through collaborations with clinical teams at MSK and HSS
Collaborative, Supportive Environment
that values teamwork, communication, and scientific curiosity
What You Will Do
Conduct experiments using in vivo mouse models, including animal handling, dissections, and tissue processing
Manage mouse colonies, including breeding and genotyping
Perform immune phenotyping via high-dimensional flow cytometry
Prepare samples for single-cell genomics workflows (scRNA‑seq / scATAC‑seq)
Carry out molecular biology and microbiology experiments (e.g., bacterial cultures, genome editing)
Maintain accurate records and protocols using an electronic lab notebook
Collaborate closely with team members, contribute to lab meetings, and assist in training new members
What You Bring
Bachelor’s degree in Biological Sciences, Biochemistry, Immunology, Microbiology, Molecular Biology, Genetics, or a related field
Required: Experience with animal handling and mouse colony management
Highly Preferred: Hands‑on experience with flow cytometry and animal dissection / tissue processing
Strong organizational and time‑management skills with the ability to thrive in a fast‑paced lab environment
Excellent communication skills and a team‑oriented mindset — enjoys collaborating and contributing to shared goals
Genuine enthusiasm for science, curiosity, and a desire to learn new techniques
Physical Requirements Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances or other hazardous materials.
Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.
Please Note: This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.
#J-18808-Ljbffr