EyeBio
Associate Scientist, Postdoctoral Fellow - Quantitative Biosciences
EyeBio, Oklahoma City, Oklahoma, United States
Job Description
Be a part of the legacy: Postdoctoral Research Fellow Program
Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best‑in‑industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
Postdoctoral Fellow, Quantitative Biosciences (In vitro Pharmacology) Location: Boston, MA
Summary : We are seeking a highly motivated Postdoctoral Fellow to join our Quantitative Biosciences team to develop physiologically relevant in‑vitro models to investigate the MoA of novel immunotherapies for inflammatory diseases. The role will focus on assay development using human intestinal organoids and primary immune cells. The Postdoctoral Fellow will design and implement the in‑vitro models to assess potency, mechanism of action, and combination effects of therapeutic candidates.
Key Responsibilities
Develop co‑culture and functional assays to measure the crosstalk between intestinal epithelial cells and immune cells.
Design experiments to profile biologics and small molecules across target panels and immune cell subsets.
Understand the pharmacology and mechanism of action of therapeutic targets in human intestinal organoids and primary immune cells.
Confirm findings in orthogonal assays with engineered cell lines and other molecular biology approaches and transcriptomics studies.
Independently design, plan, execute, and interpret assay data.
Maintain detailed experimental records.
Present the research work at internal and external meetings and publish in high‑impact journals.
Required Qualifications
Hold a Ph.D. or Ph.D. completed within 6 months of hire in Immunology, Cell Biology, or a related discipline, with a proven track record of first‑author publications.
Demonstrated ability to design, execute, and interpret complex biological experiments.
Hands‑on experience in cell culture, immune cell isolation and differentiation, and human intestinal organoid models.
Strong skills in flow cytometry, ELISA, cytokine multiplex assays, and cell‑based functional assays.
Experience with dose‑response analysis and standard pharmacology metrics.
Strong written and verbal communication skills and ability to work effectively in cross‑functional teams.
Preferred Qualifications
Prior experience in research related to IBD pathogenesis, mucosal immunology, and T cell biology.
Experience with immunofluorescence, immunohistochemical staining, and/or high‑content imaging.
Required Skills
Accountability, Accountability, Adaptability, Analytical Chemistry, Assay Development, Cell‑Based Assays, Cell Cultures, Cell Culture Techniques, Computational Biology, Cytokines, Data Analysis, Flow Cytometry, Immunoassays, Immunochemistry, Immunofluorescence Microscopy, Immunology, Immunotherapy, In Vivo Mouse Models, Mammalian Cell Culture, Mathematical Biology, Molecular Biology, Parasitology, Primary Cell Culture, Programming Languages, Scientific Research {+ 3 more}
Preferred Skills: Current Employees apply (HERE) / Current Contingent Workers apply (HERE)
U.S. Hybrid Work Model Effective September 5, 2023, employees in office‑based positions in the U.S. will be working a hybrid model consisting of three total days on‑site per week, Monday – Thursday, although the specific days may vary by site or organization, with Friday designated as a remote‑working day, unless business critical tasks require an on‑site presence. This model does not apply to, and daily in‑person attendance is required for, field‑based positions; facility‑based, manufacturing‑based, or research‑based positions where the work to be performed is located at a company site; positions covered by collective‑bargaining agreements (unless the agreement provides for hybrid work); or any other position for which the company has determined the job requirements cannot be reasonably met working remotely. Please note, this hybrid work model guidance also does not apply to roles that have been designated as “remote”.
EEO Statement As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights / EEOC GINA Supplement.
Other Information Employee Status: Regular Relocation: Domestic VISA Sponsorship: No Travel Requirements: 10% Flexible Work Arrangements: Not Applicable Shift: Not Indicated Valid Driving License: No Hazardous Material(s): n/a Job Posting End Date: 11/25/2025
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Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best‑in‑industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
Postdoctoral Fellow, Quantitative Biosciences (In vitro Pharmacology) Location: Boston, MA
Summary : We are seeking a highly motivated Postdoctoral Fellow to join our Quantitative Biosciences team to develop physiologically relevant in‑vitro models to investigate the MoA of novel immunotherapies for inflammatory diseases. The role will focus on assay development using human intestinal organoids and primary immune cells. The Postdoctoral Fellow will design and implement the in‑vitro models to assess potency, mechanism of action, and combination effects of therapeutic candidates.
Key Responsibilities
Develop co‑culture and functional assays to measure the crosstalk between intestinal epithelial cells and immune cells.
Design experiments to profile biologics and small molecules across target panels and immune cell subsets.
Understand the pharmacology and mechanism of action of therapeutic targets in human intestinal organoids and primary immune cells.
Confirm findings in orthogonal assays with engineered cell lines and other molecular biology approaches and transcriptomics studies.
Independently design, plan, execute, and interpret assay data.
Maintain detailed experimental records.
Present the research work at internal and external meetings and publish in high‑impact journals.
Required Qualifications
Hold a Ph.D. or Ph.D. completed within 6 months of hire in Immunology, Cell Biology, or a related discipline, with a proven track record of first‑author publications.
Demonstrated ability to design, execute, and interpret complex biological experiments.
Hands‑on experience in cell culture, immune cell isolation and differentiation, and human intestinal organoid models.
Strong skills in flow cytometry, ELISA, cytokine multiplex assays, and cell‑based functional assays.
Experience with dose‑response analysis and standard pharmacology metrics.
Strong written and verbal communication skills and ability to work effectively in cross‑functional teams.
Preferred Qualifications
Prior experience in research related to IBD pathogenesis, mucosal immunology, and T cell biology.
Experience with immunofluorescence, immunohistochemical staining, and/or high‑content imaging.
Required Skills
Accountability, Accountability, Adaptability, Analytical Chemistry, Assay Development, Cell‑Based Assays, Cell Cultures, Cell Culture Techniques, Computational Biology, Cytokines, Data Analysis, Flow Cytometry, Immunoassays, Immunochemistry, Immunofluorescence Microscopy, Immunology, Immunotherapy, In Vivo Mouse Models, Mammalian Cell Culture, Mathematical Biology, Molecular Biology, Parasitology, Primary Cell Culture, Programming Languages, Scientific Research {+ 3 more}
Preferred Skills: Current Employees apply (HERE) / Current Contingent Workers apply (HERE)
U.S. Hybrid Work Model Effective September 5, 2023, employees in office‑based positions in the U.S. will be working a hybrid model consisting of three total days on‑site per week, Monday – Thursday, although the specific days may vary by site or organization, with Friday designated as a remote‑working day, unless business critical tasks require an on‑site presence. This model does not apply to, and daily in‑person attendance is required for, field‑based positions; facility‑based, manufacturing‑based, or research‑based positions where the work to be performed is located at a company site; positions covered by collective‑bargaining agreements (unless the agreement provides for hybrid work); or any other position for which the company has determined the job requirements cannot be reasonably met working remotely. Please note, this hybrid work model guidance also does not apply to roles that have been designated as “remote”.
EEO Statement As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights / EEOC GINA Supplement.
Other Information Employee Status: Regular Relocation: Domestic VISA Sponsorship: No Travel Requirements: 10% Flexible Work Arrangements: Not Applicable Shift: Not Indicated Valid Driving License: No Hazardous Material(s): n/a Job Posting End Date: 11/25/2025
#J-18808-Ljbffr