DELFI Diagnostics
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Machine Learning Scientist
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DELFI Diagnostics Join to apply for the
Machine Learning Scientist
role at
DELFI Diagnostics Get AI-powered advice on this job and more exclusive features. This range is provided by DELFI Diagnostics. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more. Base pay range
$150,000.00/yr - $180,000.00/yr About Us Our mission is to cure cancer through high performance, accessible early cancer detection. That means saving lives. Delfi Diagnostics is a Johns Hopkins spinoff focused on the non-invasive detection of cancer at earlier stages, when it is most curable. DELFI uses artificial intelligence and whole-genome sequencing to detect unique patterns of DNA fragmentation in the blood of patients with cancer. These analyses are performed through simultaneous examination of millions of DNA sequences using machine learning to identify tumor-specific abnormalities. In our passionate pursuit to radically improve health outcomes, we serve humanity when we: Lead with Science, Anchor in Pragmatism : We pioneer life-changing science by ensuring quality, transparency, and rigor at all times. Build With & For All : We embrace diverse backgrounds to innovate and achieve together. We are not just building a product—we aim to disrupt the path of cancer for all, no matter geography or socioeconomic class. Put We over I : We are a home for high-performing people. Through teamwork, we build collective intelligence. Each of us wins when those we serve and those who serve with us win. We show up with empathy, humility, and integrity at every step of the journey. About the Role In this role, you will develop, tune, and advance Delfi’s machine learning models for early cancer detection. You’ll focus on improving model performance through structured experimentation, creative modeling strategies, and rigorous benchmarking—pushing models up internal leaderboards and identifying what drives improvement. You’ll also explore how the raw intelligence of large language models (LLMs) can be applied to improve model performance and feature representations—leveraging their reasoning capabilities. Working closely with bioinformaticians, software engineers, and data scientists, you’ll operate at the intersection of machine learning and biology, translating genomic signals into clinically meaningful insight. This role is ideal for a scientist who enjoys hands-on modeling, thrives on iteration and discovery, and seeks to combine deep technical understanding with curiosity about new forms of machine intelligence. About Us Our mission is to cure cancer through high performance, accessible early cancer detection. That means saving lives. Delfi Diagnostics is a Johns Hopkins spinoff focused on the non-invasive detection of cancer at earlier stages, when it is most curable. DELFI uses artificial intelligence and whole-genome sequencing to detect unique patterns of DNA fragmentation in the blood of patients with cancer. These analyses are performed through simultaneous examination of millions of DNA sequences using machine learning to identify tumor-specific abnormalities. In our passionate pursuit to radically improve health outcomes, we serve humanity when we: Lead with Science, Anchor in Pragmatism : We pioneer life-changing science by ensuring quality, transparency, and rigor at all times. Build With & For All : We embrace diverse backgrounds to innovate and achieve together. We are not just building a product—we aim to disrupt the path of cancer for all, no matter geography or socioeconomic class. Put We over I : We are a home for high-performing people. Through teamwork, we build collective intelligence. Each of us wins when those we serve and those who serve with us win. We show up with empathy, humility, and integrity at every step of the journey. About the Role In this role, you will develop, tune, and advance Delfi’s machine learning models for early cancer detection. You’ll focus on improving model performance through structured experimentation, creative modeling strategies, and rigorous benchmarking—pushing models up internal leaderboards and identifying what drives improvement. You’ll also explore how the raw intelligence of large language models (LLMs) can be applied to improve model performance and feature representations—leveraging their reasoning capabilities. Working closely with bioinformaticians, software engineers, and data scientists, you’ll operate at the intersection of machine learning and biology, translating genomic signals into clinically meaningful insight. This role is ideal for a scientist who enjoys hands-on modeling, thrives on iteration and discovery, and seeks to combine deep technical understanding with curiosity about new forms of machine intelligence. What You'll Do
You’ll design, implement, and optimize machine learning models for genomic and fragmentomic data, perform systematic benchmarking to assess model quality, and analyze the factors that drive predictive improvements. You’ll explore the use of LLMs to enhance feature representations and model architectures. You’ll ensure robust, reproducible experimentation through sound data practices and MLOps best practices such as versioning, model tracking, and environment management. You’ll collaborate closely with teams across computational biology, bioinformatics, and software engineering to build shared understanding and integrate insights from data
What You'll Have Accomplished 12 Months From Now
You will have led multiple modeling efforts that improved performance on Delfi’s internal leaderboards through careful experimentation and analysis. You will have evaluated and demonstrated how LLMs can strengthen feature representations or model architectures to achieve measurable performance gains. You will be recognized as a rigorous and creative contributor—someone who combines scientific depth with curiosity and collaboration to drive the frontier of ML for early cancer detection
What You'll Bring to DELFI
PhD in Computer Science, Machine Learning, Computational Biology, Applied Mathematics, or a related field 2 or more years of relevant industry or post-doctorate experience Experience developing and evaluating ML models in applied or collaborative research settings, with a demonstrated ability to deliver high-quality, maintainable code and reproducible results Experience working in team-based environments with shared codebases and version control practices Proficiency in Python, including use of ML frameworks such as PyTorch, TensorFlow, or scikit-learn Experience applying MLOps best practices for experiment tracking, model versioning, or data pipeline reproducibility (e.g., MLflow, Weights & Biases, or equivalent) Demonstrated success improving model performance through experimentation, architecture design, or advanced optimization methods Familiarity with large language models (LLMs), including APIs, frameworks, and fine-tuning methods Strong grounding in statistics, data analysis, and reproducible experimentation Excellent communication skills and the ability to collaborate effectively across scientific and technical disciplines A demonstrated record of scientific communication, including at least one peer-reviewed publication in a recognized ML conference or scientific journal
Preferred
Experience with genomic, sequencing, or other biological data Exposure to cloud-based ML environments (AWS, GCP) or large-scale data pipelines Background in deep learning, probabilistic modeling, or ensemble methods
An Equal Opportunity Employer We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
Total Compensation at DELFI is a combination of salary, bonus, equity, and benefits. Actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skillset, years & depth of experience, certifications & relevant education, geography. Seniority level
Seniority level Not Applicable Employment type
Employment type Full-time Job function
Job function Other Industries Biotechnology Research, Technology, Information and Internet, and Software Development Referrals increase your chances of interviewing at DELFI Diagnostics by 2x Get notified about new Machine Learning Researcher jobs in
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Machine Learning Scientist
role at
DELFI Diagnostics Join to apply for the
Machine Learning Scientist
role at
DELFI Diagnostics Get AI-powered advice on this job and more exclusive features. This range is provided by DELFI Diagnostics. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more. Base pay range
$150,000.00/yr - $180,000.00/yr About Us Our mission is to cure cancer through high performance, accessible early cancer detection. That means saving lives. Delfi Diagnostics is a Johns Hopkins spinoff focused on the non-invasive detection of cancer at earlier stages, when it is most curable. DELFI uses artificial intelligence and whole-genome sequencing to detect unique patterns of DNA fragmentation in the blood of patients with cancer. These analyses are performed through simultaneous examination of millions of DNA sequences using machine learning to identify tumor-specific abnormalities. In our passionate pursuit to radically improve health outcomes, we serve humanity when we: Lead with Science, Anchor in Pragmatism : We pioneer life-changing science by ensuring quality, transparency, and rigor at all times. Build With & For All : We embrace diverse backgrounds to innovate and achieve together. We are not just building a product—we aim to disrupt the path of cancer for all, no matter geography or socioeconomic class. Put We over I : We are a home for high-performing people. Through teamwork, we build collective intelligence. Each of us wins when those we serve and those who serve with us win. We show up with empathy, humility, and integrity at every step of the journey. About the Role In this role, you will develop, tune, and advance Delfi’s machine learning models for early cancer detection. You’ll focus on improving model performance through structured experimentation, creative modeling strategies, and rigorous benchmarking—pushing models up internal leaderboards and identifying what drives improvement. You’ll also explore how the raw intelligence of large language models (LLMs) can be applied to improve model performance and feature representations—leveraging their reasoning capabilities. Working closely with bioinformaticians, software engineers, and data scientists, you’ll operate at the intersection of machine learning and biology, translating genomic signals into clinically meaningful insight. This role is ideal for a scientist who enjoys hands-on modeling, thrives on iteration and discovery, and seeks to combine deep technical understanding with curiosity about new forms of machine intelligence. About Us Our mission is to cure cancer through high performance, accessible early cancer detection. That means saving lives. Delfi Diagnostics is a Johns Hopkins spinoff focused on the non-invasive detection of cancer at earlier stages, when it is most curable. DELFI uses artificial intelligence and whole-genome sequencing to detect unique patterns of DNA fragmentation in the blood of patients with cancer. These analyses are performed through simultaneous examination of millions of DNA sequences using machine learning to identify tumor-specific abnormalities. In our passionate pursuit to radically improve health outcomes, we serve humanity when we: Lead with Science, Anchor in Pragmatism : We pioneer life-changing science by ensuring quality, transparency, and rigor at all times. Build With & For All : We embrace diverse backgrounds to innovate and achieve together. We are not just building a product—we aim to disrupt the path of cancer for all, no matter geography or socioeconomic class. Put We over I : We are a home for high-performing people. Through teamwork, we build collective intelligence. Each of us wins when those we serve and those who serve with us win. We show up with empathy, humility, and integrity at every step of the journey. About the Role In this role, you will develop, tune, and advance Delfi’s machine learning models for early cancer detection. You’ll focus on improving model performance through structured experimentation, creative modeling strategies, and rigorous benchmarking—pushing models up internal leaderboards and identifying what drives improvement. You’ll also explore how the raw intelligence of large language models (LLMs) can be applied to improve model performance and feature representations—leveraging their reasoning capabilities. Working closely with bioinformaticians, software engineers, and data scientists, you’ll operate at the intersection of machine learning and biology, translating genomic signals into clinically meaningful insight. This role is ideal for a scientist who enjoys hands-on modeling, thrives on iteration and discovery, and seeks to combine deep technical understanding with curiosity about new forms of machine intelligence. What You'll Do
You’ll design, implement, and optimize machine learning models for genomic and fragmentomic data, perform systematic benchmarking to assess model quality, and analyze the factors that drive predictive improvements. You’ll explore the use of LLMs to enhance feature representations and model architectures. You’ll ensure robust, reproducible experimentation through sound data practices and MLOps best practices such as versioning, model tracking, and environment management. You’ll collaborate closely with teams across computational biology, bioinformatics, and software engineering to build shared understanding and integrate insights from data
What You'll Have Accomplished 12 Months From Now
You will have led multiple modeling efforts that improved performance on Delfi’s internal leaderboards through careful experimentation and analysis. You will have evaluated and demonstrated how LLMs can strengthen feature representations or model architectures to achieve measurable performance gains. You will be recognized as a rigorous and creative contributor—someone who combines scientific depth with curiosity and collaboration to drive the frontier of ML for early cancer detection
What You'll Bring to DELFI
PhD in Computer Science, Machine Learning, Computational Biology, Applied Mathematics, or a related field 2 or more years of relevant industry or post-doctorate experience Experience developing and evaluating ML models in applied or collaborative research settings, with a demonstrated ability to deliver high-quality, maintainable code and reproducible results Experience working in team-based environments with shared codebases and version control practices Proficiency in Python, including use of ML frameworks such as PyTorch, TensorFlow, or scikit-learn Experience applying MLOps best practices for experiment tracking, model versioning, or data pipeline reproducibility (e.g., MLflow, Weights & Biases, or equivalent) Demonstrated success improving model performance through experimentation, architecture design, or advanced optimization methods Familiarity with large language models (LLMs), including APIs, frameworks, and fine-tuning methods Strong grounding in statistics, data analysis, and reproducible experimentation Excellent communication skills and the ability to collaborate effectively across scientific and technical disciplines A demonstrated record of scientific communication, including at least one peer-reviewed publication in a recognized ML conference or scientific journal
Preferred
Experience with genomic, sequencing, or other biological data Exposure to cloud-based ML environments (AWS, GCP) or large-scale data pipelines Background in deep learning, probabilistic modeling, or ensemble methods
An Equal Opportunity Employer We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
Total Compensation at DELFI is a combination of salary, bonus, equity, and benefits. Actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skillset, years & depth of experience, certifications & relevant education, geography. Seniority level
Seniority level Not Applicable Employment type
Employment type Full-time Job function
Job function Other Industries Biotechnology Research, Technology, Information and Internet, and Software Development Referrals increase your chances of interviewing at DELFI Diagnostics by 2x Get notified about new Machine Learning Researcher jobs in
Palo Alto, CA . Full Stack Software Engineer (L5) - Internal Tools
Software Engineer (L4), Content & Business Products
Software Engineer, AI Platform - New Grad
Mountain View, CA $145,000.00-$170,000.00 2 weeks ago Mountain View, CA $55.50-$75.00 6 days ago San Francisco Bay Area $160,000.00-$180,000.00 2 weeks ago Full Stack Engineer (L5) - Consumer Data Systems
Mountain View, CA $114,000.00-$189,000.00 2 weeks ago San Jose, CA $113,400.00-$206,300.00 3 days ago Palo Alto, CA $85,000.00-$150,000.00 2 weeks ago San Jose, CA $113,400.00-$206,300.00 2 weeks ago Software Engineer - New Grad (Summer 2026)
Foster City, CA $140,000.00-$180,000.00 2 weeks ago San Jose, CA $116,500.00-$173,250.00 3 days ago Redwood City, CA $85,000.00-$150,000.00 2 weeks ago Software Engineer (L5) - Internal Tooling
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#J-18808-Ljbffr