Medicilon Inc.
Scientist – DMPK / Bioanalysis
Medicilon Inc., Lexington, Massachusetts, United States, 02173
HR and Operations Manager at Medicilon USA Corp
Medicilon USA Corp is seeking a highly motivated
Scientist
to join our
DMPK and Bioanalysis
team. The ideal candidate will possess a strong foundation in pharmacokinetics, bioanalytical method development, and in vivo/in vitro pharmacology studies. This role involves both hands‑on experimentation and independent planning, execution, and analysis of studies to support preclinical drug development. The Scientist will work closely with cross‑functional teams and contribute to the strategic direction of both client‑sponsored and internal projects.
Key Responsibilities
Design and execute bioanalytical studies to support PK, PD, TK, biomarker, and biodistribution assessments using LC-MS/MS, ELISA/MSD, qPCR/ddPCR, and cell‑based assays.
Independently develop, optimize, and validate LC-MS methods for qualitative and quantitative analysis of small molecules, oligonucleotides, biologics, and novel modalities.
Conduct in vitro and in vivo DMPK studies, including dosing, sample collection (e.g., blood, plasma, tissues), and data interpretation.
Maintain and troubleshoot lab instrumentation (LC-MS, HPLC, plate readers, thermocyclers).
Analyze and interpret data, troubleshoot issues, and ensure data quality and integrity.
Accurately document protocols and results in lab notebooks; contribute to formal reports and regulatory submissions.
Mentor junior team members and collaborate with project leads to ensure timely study execution.
Stay current with advances in DMPK and bioanalytical methods; apply new knowledge to project designs.
Participate in team meetings and present scientific findings to internal stakeholders and clients.
Qualifications
M.S. or Ph.D. in Pharmacology, Biochemistry, Analytical Chemistry, or related field
3+ years of industry or CRO experience in DMPK, bioanalysis, or preclinical research
Hands‑on experience in LC-MS/MS method development, sample prep, and quantitative analysis of small molecules, oligonucleotides, biologics, and CGT products
Familiarity with in vitro ADME and in vivo PK studies, including animal dosing and biological sample handling
Strong documentation practices with working knowledge of GLP/GxP standards
Excellent teamwork, communication, and time management skills
Preferred Qualifications
CRO experience with direct client interaction
Familiarity with regulatory guidance for bioanalytical method validation (FDA, EMA)
Advanced skills in techniques such as LBA-LC/MS/MS, HRMS for MetID, flow cytometry, or immunogenicity assays
Broad understanding of bioanalytical workflows across biologics, oligonucleotide therapies (OGT), CGT, and other novel drug classes
Seniority Level Mid‑Senior level
Employment Type Full‑time
Industries Pharmaceutical Manufacturing
Referrals increase your chances of interviewing at Medicilon Inc. by 2x
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Lexington, MA .
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Scientist
to join our
DMPK and Bioanalysis
team. The ideal candidate will possess a strong foundation in pharmacokinetics, bioanalytical method development, and in vivo/in vitro pharmacology studies. This role involves both hands‑on experimentation and independent planning, execution, and analysis of studies to support preclinical drug development. The Scientist will work closely with cross‑functional teams and contribute to the strategic direction of both client‑sponsored and internal projects.
Key Responsibilities
Design and execute bioanalytical studies to support PK, PD, TK, biomarker, and biodistribution assessments using LC-MS/MS, ELISA/MSD, qPCR/ddPCR, and cell‑based assays.
Independently develop, optimize, and validate LC-MS methods for qualitative and quantitative analysis of small molecules, oligonucleotides, biologics, and novel modalities.
Conduct in vitro and in vivo DMPK studies, including dosing, sample collection (e.g., blood, plasma, tissues), and data interpretation.
Maintain and troubleshoot lab instrumentation (LC-MS, HPLC, plate readers, thermocyclers).
Analyze and interpret data, troubleshoot issues, and ensure data quality and integrity.
Accurately document protocols and results in lab notebooks; contribute to formal reports and regulatory submissions.
Mentor junior team members and collaborate with project leads to ensure timely study execution.
Stay current with advances in DMPK and bioanalytical methods; apply new knowledge to project designs.
Participate in team meetings and present scientific findings to internal stakeholders and clients.
Qualifications
M.S. or Ph.D. in Pharmacology, Biochemistry, Analytical Chemistry, or related field
3+ years of industry or CRO experience in DMPK, bioanalysis, or preclinical research
Hands‑on experience in LC-MS/MS method development, sample prep, and quantitative analysis of small molecules, oligonucleotides, biologics, and CGT products
Familiarity with in vitro ADME and in vivo PK studies, including animal dosing and biological sample handling
Strong documentation practices with working knowledge of GLP/GxP standards
Excellent teamwork, communication, and time management skills
Preferred Qualifications
CRO experience with direct client interaction
Familiarity with regulatory guidance for bioanalytical method validation (FDA, EMA)
Advanced skills in techniques such as LBA-LC/MS/MS, HRMS for MetID, flow cytometry, or immunogenicity assays
Broad understanding of bioanalytical workflows across biologics, oligonucleotide therapies (OGT), CGT, and other novel drug classes
Seniority Level Mid‑Senior level
Employment Type Full‑time
Industries Pharmaceutical Manufacturing
Referrals increase your chances of interviewing at Medicilon Inc. by 2x
Get notified about new Scientist jobs in
Lexington, MA .
#J-18808-Ljbffr