Eli Lilly and
Scientist / Sr. Scientist – Protein Purification
Eli Lilly and, Indianapolis, Indiana, us, 46262
Overview
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We put people first and are looking for people who are determined to make life better for people around the world. Organization Overview : Eli Lilly’s Biotechnology Discovery Research (BioTDR) organization discovers, optimizes, and delivers novel biotherapeutic medicines to the clinic for unmet medical needs in diabetes, oncology, immunology, and neuroscience. This position is within the BioTDR Lead Optimization Group’s Protein Expression and Purification Team. The successful candidate will advance projects and emerging platforms in BioTDR and collaborate across the discovery organization to deliver Lilly’s early phase portfolio. The ideal candidate will have extensive hands-on experience with chromatography systems and a track record of purifying diverse proteins in a fast-paced, collaborative environment. Responsibilities
Design, develop, and execute protein purification strategies for diverse biotherapeutic modalities (e.g., monoclonal antibodies, multichain bispecific antibodies, Fab fragments, VHH, bioconjugates, etc.) and diverse reagent proteins. Operate and maintain AKTA chromatography systems (e.g., AKTA Pure) for protein purification workflows ranging from milligram to multi-gram scale. Perform analytical characterization of purified proteins including purity assessment and concentration determination. Influence the protein production workplans as an integral member of emerging biotherapeutic platform teams. Basic Requirements
Master's degree in Biochemistry, Chemistry, Biology, or related field with relevant industry experience, OR Bachelor's degree in Biochemistry, Chemistry, Biology, or related field with 2+ years of relevant industry experience. Proficiency with AKTA chromatography systems and hands-on experience purifying diverse modalities: monoclonal antibodies, Fab fragments, VHH, or other recombinant proteins. Additional Skills/Preferences
Experience with multiple chromatography techniques (affinity, IEX, HIC, SEC). Experience with bioconjugation of targeted lipid nanoparticles, including downstream purification and characterization. Proficiency with UNICORN software. Experience with automated liquid handling systems and high-throughput purification platforms. Experience with protein analytical techniques such as SDS-PAGE, CE-SDS, cIEF, analytical HPLC, and related methods. Experience with microbial and mammalian expression systems (HEK293, CHO) for production of milligram-to-gram scale proteins. Experience with bioconjugation and/or targeted lipid nanoparticles. Innovation in protein purification as demonstrated by a publication record. Effective collaboration in a matrix environment with protein engineers, biochemists, biologists, and development scientists. Strong verbal and written communication skills and the ability to share learnings across team boundaries. Excellent time management and organizational skills with the ability to adapt to changing priorities and deadlines and thrive in ambiguity. Experience with Benchling electronic laboratory notebook and data analytics. Driving a culture of safety and inclusion in the workplace, including coaching and mentoring peers and other scientists. Additional Information
Location: Indianapolis, Indiana Travel: 0-10% Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form at https://careers.lilly.com/us/en/workplace-accommodation for further assistance. This is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks and are open to all employees. Groups include Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $65,250 - $169,400. Full-time employees will also be eligible for a company bonus (depending, in part, on company and individual performance). Lilly offers a comprehensive benefits package, including eligibility for a 401(k); pension; vacation benefits; medical, dental, vision and prescription drug benefits; flexible benefits; life insurance and other time off and leave benefits; and well-being programs. Lilly reserves the right to amend, modify, or terminate its compensation and benefits programs at its discretion. #WeAreLilly
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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We put people first and are looking for people who are determined to make life better for people around the world. Organization Overview : Eli Lilly’s Biotechnology Discovery Research (BioTDR) organization discovers, optimizes, and delivers novel biotherapeutic medicines to the clinic for unmet medical needs in diabetes, oncology, immunology, and neuroscience. This position is within the BioTDR Lead Optimization Group’s Protein Expression and Purification Team. The successful candidate will advance projects and emerging platforms in BioTDR and collaborate across the discovery organization to deliver Lilly’s early phase portfolio. The ideal candidate will have extensive hands-on experience with chromatography systems and a track record of purifying diverse proteins in a fast-paced, collaborative environment. Responsibilities
Design, develop, and execute protein purification strategies for diverse biotherapeutic modalities (e.g., monoclonal antibodies, multichain bispecific antibodies, Fab fragments, VHH, bioconjugates, etc.) and diverse reagent proteins. Operate and maintain AKTA chromatography systems (e.g., AKTA Pure) for protein purification workflows ranging from milligram to multi-gram scale. Perform analytical characterization of purified proteins including purity assessment and concentration determination. Influence the protein production workplans as an integral member of emerging biotherapeutic platform teams. Basic Requirements
Master's degree in Biochemistry, Chemistry, Biology, or related field with relevant industry experience, OR Bachelor's degree in Biochemistry, Chemistry, Biology, or related field with 2+ years of relevant industry experience. Proficiency with AKTA chromatography systems and hands-on experience purifying diverse modalities: monoclonal antibodies, Fab fragments, VHH, or other recombinant proteins. Additional Skills/Preferences
Experience with multiple chromatography techniques (affinity, IEX, HIC, SEC). Experience with bioconjugation of targeted lipid nanoparticles, including downstream purification and characterization. Proficiency with UNICORN software. Experience with automated liquid handling systems and high-throughput purification platforms. Experience with protein analytical techniques such as SDS-PAGE, CE-SDS, cIEF, analytical HPLC, and related methods. Experience with microbial and mammalian expression systems (HEK293, CHO) for production of milligram-to-gram scale proteins. Experience with bioconjugation and/or targeted lipid nanoparticles. Innovation in protein purification as demonstrated by a publication record. Effective collaboration in a matrix environment with protein engineers, biochemists, biologists, and development scientists. Strong verbal and written communication skills and the ability to share learnings across team boundaries. Excellent time management and organizational skills with the ability to adapt to changing priorities and deadlines and thrive in ambiguity. Experience with Benchling electronic laboratory notebook and data analytics. Driving a culture of safety and inclusion in the workplace, including coaching and mentoring peers and other scientists. Additional Information
Location: Indianapolis, Indiana Travel: 0-10% Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form at https://careers.lilly.com/us/en/workplace-accommodation for further assistance. This is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks and are open to all employees. Groups include Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $65,250 - $169,400. Full-time employees will also be eligible for a company bonus (depending, in part, on company and individual performance). Lilly offers a comprehensive benefits package, including eligibility for a 401(k); pension; vacation benefits; medical, dental, vision and prescription drug benefits; flexible benefits; life insurance and other time off and leave benefits; and well-being programs. Lilly reserves the right to amend, modify, or terminate its compensation and benefits programs at its discretion. #WeAreLilly
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