Olema Oncology
Senior Medical Director, Clinical Development
Olema Oncology, San Francisco, California, United States, 94199
Senior Medical Director, Clinical Development
Olema Oncology is dedicated to developing better medicines for breast cancer and beyond. Our lead program, palazestrant (OP-1250), is a complete estrogen receptor antagonist (CERAN) currently in development for metastatic breast cancer with blockbuster potential as a monotherapy and in combination in ER+/HER2- metastatic breast cancer. Our follow-on product candidate, OP-3136, is a potent KAT6 inhibitor with best-in-class potential.
Our scientific breakthroughs are accelerated through the ways in which we fearlessly support, motivate, and challenge one another. At Olema, we know that when we put people first, our work becomes second to none. If you’re ready to join us at the edge of something unstoppable, let’s make a profound impact together for
our patients, for your career, for what’s beyond .
You can view our latest corporate deck and other presentations here .
As the
Senior Medical Director , reporting to the
SVP of Clinical Development , you will serve as the
Oncology Physician Lead for palazestrant
and play a pivotal role in advancing Olema’s late-stage clinical pipeline.
You will guide
registration-enabling studies
by shaping study design, evaluating clinical data, and engaging with regulatory authorities, investigators, and key opinion leaders. Partnering closely with experienced physicians and cross-functional teams, you will ensure
scientific rigor, data integrity, and patient-centered decision-making
while contributing to biomarker development, publication planning, and external scientific communications.
This is a unique opportunity to contribute at a pivotal moment in the program’s trajectory and support the advancement of therapies for patients with
ER-positive, HER2-negative breast cancer.
This role may be based in either
San Francisco, CA
or
Cambridge, MA
and may require up to
20% travel .
Key Responsibilities Provide Medical Leadership and Expertise
Lead registration-enabling studies for palazestrant in combination with other therapies, including study design, regulatory engagement, and investigator collaboration
Partner across functions to define and implement clinical development strategies and plans for multiple programs
Serve as the primary medical expert and point of contact for clinical and scientific questions across internal and external stakeholders
Represent Olema in interactions with investigators, academic collaborators, thought leaders, and regulatory authorities
Maintain strong clinical and scientific acumen through ongoing engagement with the oncology community and key scientific meetings
Design and Deliver High-Impact Clinical Studies
Provide medical oversight and partner with CROs for Phase 3 programs and ensure alignment with Olema’s values, SOPs, and ethical standards
Lead the development and execution of clinical protocols, amendments, investigator brochures, study reports, abstracts, and manuscripts
Ensure scientific rigor and data integrity in partnership with cross-functional internal teams (i.e. Clinical Operations, Biostatistics, Safety) and CRO teams
Evaluate safety, pharmacology, and efficacy data from ongoing and completed studies to inform program strategy and decision-making
Contribute to regulatory submissions and communications
Collaborate with preclinical and translational scientists to develop and integrate biomarker strategies
Support data generation, publication planning, and external communication of study results
Ideal Candidate Profile: Experienced Oncology Physician Leader You are an accomplished clinical development physician who thrives on meaningful, challenging work and is motivated by the opportunity to make a lasting impact on patients’ lives. You combine deep clinical and scientific expertise with strategic vision, collaboration, and a hands‑on approach to execution.
Knowledge
MD required
Board certification
in Oncology, Hematology/Oncology, or related specialty; significant experience in breast cancer may substitute
5+ years
of direct biotech or pharmaceutical experience in clinical development, with leadership in
late-phase studies
Strong understanding of
breast cancer treatment paradigms ; experience with ER+/HER2- disease preferred
Experience
Proven success in
designing, leading, and managing late-phase (registrational) studies
in oncology; experience as a PI or academic breast cancer expert is also valued
Deep understanding of the
drug development process
and ability to translate strategy into action—meeting milestones, managing budgets, and adapting to change
Strong knowledge of
GCP ,
FDA , and
EMA/CHMP
regulations; familiarity with other global regulatory standards is advantageous
Effective leadership in a
matrixed environment , influencing without authority and driving cross-functional alignment
Exceptional communication skills—able to
convey complex clinical data
with clarity and purpose to both scientific and non-scientific audiences
Demonstrated problem‑solving ability with
urgency ,
focus , and
creativity
Proven record of building collaborative, high‑performing teams and partnerships
Highly organized, detail‑oriented, and adaptable to fast‑paced, evolving priorities
Attributes
Strategic, decisive, and collaborative leader who inspires confidence and trust
Strong communicator with credibility among internal teams and external stakeholders
Relationship builder who thrives in a dynamic, mission‑driven environment
Committed to lifelong learning and continuous professional growth
The base pay range for this position is expected to be
$315,000 - $350,000
annually, however the base pay offered may vary depending on location, market, job related knowledge, skills and capabilities, and experience. The total compensation package for this position also includes equity, bonus, and benefits.
#LI-AD1
We provide
equal opportunity to all employees and applicants for employment
and believe that great ideas and discoveries come from a mix of expertise, background, and experience. Olema is building a culture where the value of difference is celebrated.
We offer a
competitive compensation and benefits package , seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long‑term careers. A Summary of Benefits is available for all applicants.
Please note: Olema doesn’t accept agency resumes and is not responsible for any fees related to unsolicited resumes. Thank you.
Fraud Alert
: We are aware of employment scams where individuals pose as representatives of Olema Oncologyand make false use of our company name to defraud job seekers. To protect yourself, please note that Olema’s official email addresses end in @olema.com. Our official corporate website is olema.com ; our careers page isolema.com/careers ; our LinkedIn page islinkedin.com/company/olema-oncology .Please visit these links for official information from Olema. Communication from any other variant is fraudulent. Olema does not conduct interviews via text message/messaging platforms, will not ask you to download anything as part of your interview, will never request any form of payment, provide upfront paymentsof any kind, and does not make job offers without an in‑person interview.
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Our scientific breakthroughs are accelerated through the ways in which we fearlessly support, motivate, and challenge one another. At Olema, we know that when we put people first, our work becomes second to none. If you’re ready to join us at the edge of something unstoppable, let’s make a profound impact together for
our patients, for your career, for what’s beyond .
You can view our latest corporate deck and other presentations here .
As the
Senior Medical Director , reporting to the
SVP of Clinical Development , you will serve as the
Oncology Physician Lead for palazestrant
and play a pivotal role in advancing Olema’s late-stage clinical pipeline.
You will guide
registration-enabling studies
by shaping study design, evaluating clinical data, and engaging with regulatory authorities, investigators, and key opinion leaders. Partnering closely with experienced physicians and cross-functional teams, you will ensure
scientific rigor, data integrity, and patient-centered decision-making
while contributing to biomarker development, publication planning, and external scientific communications.
This is a unique opportunity to contribute at a pivotal moment in the program’s trajectory and support the advancement of therapies for patients with
ER-positive, HER2-negative breast cancer.
This role may be based in either
San Francisco, CA
or
Cambridge, MA
and may require up to
20% travel .
Key Responsibilities Provide Medical Leadership and Expertise
Lead registration-enabling studies for palazestrant in combination with other therapies, including study design, regulatory engagement, and investigator collaboration
Partner across functions to define and implement clinical development strategies and plans for multiple programs
Serve as the primary medical expert and point of contact for clinical and scientific questions across internal and external stakeholders
Represent Olema in interactions with investigators, academic collaborators, thought leaders, and regulatory authorities
Maintain strong clinical and scientific acumen through ongoing engagement with the oncology community and key scientific meetings
Design and Deliver High-Impact Clinical Studies
Provide medical oversight and partner with CROs for Phase 3 programs and ensure alignment with Olema’s values, SOPs, and ethical standards
Lead the development and execution of clinical protocols, amendments, investigator brochures, study reports, abstracts, and manuscripts
Ensure scientific rigor and data integrity in partnership with cross-functional internal teams (i.e. Clinical Operations, Biostatistics, Safety) and CRO teams
Evaluate safety, pharmacology, and efficacy data from ongoing and completed studies to inform program strategy and decision-making
Contribute to regulatory submissions and communications
Collaborate with preclinical and translational scientists to develop and integrate biomarker strategies
Support data generation, publication planning, and external communication of study results
Ideal Candidate Profile: Experienced Oncology Physician Leader You are an accomplished clinical development physician who thrives on meaningful, challenging work and is motivated by the opportunity to make a lasting impact on patients’ lives. You combine deep clinical and scientific expertise with strategic vision, collaboration, and a hands‑on approach to execution.
Knowledge
MD required
Board certification
in Oncology, Hematology/Oncology, or related specialty; significant experience in breast cancer may substitute
5+ years
of direct biotech or pharmaceutical experience in clinical development, with leadership in
late-phase studies
Strong understanding of
breast cancer treatment paradigms ; experience with ER+/HER2- disease preferred
Experience
Proven success in
designing, leading, and managing late-phase (registrational) studies
in oncology; experience as a PI or academic breast cancer expert is also valued
Deep understanding of the
drug development process
and ability to translate strategy into action—meeting milestones, managing budgets, and adapting to change
Strong knowledge of
GCP ,
FDA , and
EMA/CHMP
regulations; familiarity with other global regulatory standards is advantageous
Effective leadership in a
matrixed environment , influencing without authority and driving cross-functional alignment
Exceptional communication skills—able to
convey complex clinical data
with clarity and purpose to both scientific and non-scientific audiences
Demonstrated problem‑solving ability with
urgency ,
focus , and
creativity
Proven record of building collaborative, high‑performing teams and partnerships
Highly organized, detail‑oriented, and adaptable to fast‑paced, evolving priorities
Attributes
Strategic, decisive, and collaborative leader who inspires confidence and trust
Strong communicator with credibility among internal teams and external stakeholders
Relationship builder who thrives in a dynamic, mission‑driven environment
Committed to lifelong learning and continuous professional growth
The base pay range for this position is expected to be
$315,000 - $350,000
annually, however the base pay offered may vary depending on location, market, job related knowledge, skills and capabilities, and experience. The total compensation package for this position also includes equity, bonus, and benefits.
#LI-AD1
We provide
equal opportunity to all employees and applicants for employment
and believe that great ideas and discoveries come from a mix of expertise, background, and experience. Olema is building a culture where the value of difference is celebrated.
We offer a
competitive compensation and benefits package , seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long‑term careers. A Summary of Benefits is available for all applicants.
Please note: Olema doesn’t accept agency resumes and is not responsible for any fees related to unsolicited resumes. Thank you.
Fraud Alert
: We are aware of employment scams where individuals pose as representatives of Olema Oncologyand make false use of our company name to defraud job seekers. To protect yourself, please note that Olema’s official email addresses end in @olema.com. Our official corporate website is olema.com ; our careers page isolema.com/careers ; our LinkedIn page islinkedin.com/company/olema-oncology .Please visit these links for official information from Olema. Communication from any other variant is fraudulent. Olema does not conduct interviews via text message/messaging platforms, will not ask you to download anything as part of your interview, will never request any form of payment, provide upfront paymentsof any kind, and does not make job offers without an in‑person interview.
Apply for this job *
indicates a required field
First Name *
Last Name *
Preferred First Name
Email *
Phone
Country *
Phone *
Resume/CV *
Enter manually
Accepted file types: pdf, doc, docx, txt, rtf
Enter manually
Accepted file types: pdf, doc, docx, txt, rtf
Home Address *
City *
State *
LinkedIn Profile *
Website
Are you legally authorized to work in the United States? * Select...
Do you now or will you in the future require employer sponsorship? * Select...
#J-18808-Ljbffr