Olema Oncology
Senior Medical Director, Clinical Development
Olema Oncology, Boston, Massachusetts, us, 02298
Senior Medical Director, Clinical Development
Join to apply for the Senior Medical Director, Clinical Development role at Olema Oncology.
Olema Oncology is dedicated to developing better medicines for breast cancer and beyond. Our lead program, palazestrant (OP-1250), is a complete estrogen receptor antagonist currently in development for metastatic breast cancer with blockbuster potential as a monotherapy and in combination in ER+/HER2- metastatic breast cancer. Our follow-on product candidate, OP-3136, is a potent KAT6 inhibitor with best-in-class potential.
As the Senior Medical Director, reporting to the SVP of Clinical Development, you will serve as the Oncology Physician Lead for palazestrant and play a pivotal role in advancing Olema’s late-stage clinical pipeline.
This role may be based in either San Francisco, CA or Cambridge, MA and may require up to 20% travel.
Key Responsibilities
Lead registration-enabling studies for palazestrant in combination with other therapies, including study design, regulatory engagement, and investigator collaboration.
Partner across functions to define and implement clinical development strategies and plans for multiple programs.
Serve as the primary medical expert and point of contact for clinical and scientific questions across internal and external stakeholders.
Represent Olema in interactions with investigators, academic collaborators, thought leaders, and regulatory authorities.
Maintain strong clinical and scientific acumen through ongoing engagement with the oncology community and key scientific meetings.
Design and Deliver High-Impact Clinical Studies
Provide medical oversight and partner with CROs for Phase 3 programs and ensure alignment with Olema’s values, SOPs, and ethical standards.
Lead the development and execution of clinical protocols, amendments, investigator brochures, study reports, abstracts, and manuscripts.
Ensure scientific rigor and data integrity in partnership with cross-functional internal teams and CRO teams.
Evaluate safety, pharmacology, and efficacy data from ongoing and completed studies to inform program strategy and decision-making.
Contribute to regulatory submissions and communications.
Collaborate with preclinical and translational scientists to develop and integrate biomarker strategies.
Support data generation, publication planning, and external communication of study results.
Ideal Candidate Profile: Experienced Oncology Physician Leader You are an accomplished clinical development physician who thrives on meaningful, challenging work and is motivated by the opportunity to make a lasting impact on patients’ lives. You combine deep clinical and scientific expertise with strategic vision, collaboration, and a hands‑on approach to execution.
Knowledge
MD required.
Board certification in Oncology, Hematology/Oncology, or related specialty; significant experience in breast cancer may substitute.
5+ years of direct biotech or pharmaceutical experience in clinical development, with leadership in late-phase studies.
Strong understanding of breast cancer treatment paradigms; experience with ER+/HER2- disease preferred.
Experience
Proven success in designing, leading, and managing late-phase (registrational) studies in oncology; experience as a PI or academic breast cancer expert is also valued.
Deep understanding of the drug development process and ability to translate strategy into action—meeting milestones, managing budgets, and adapting to change.
Strong knowledge of GCP, FDA, and EMA/CHMP regulations; familiarity with other global regulatory standards is advantageous.
Effective leadership in a matrixed environment, influencing without authority and driving cross-functional alignment.
Exceptional communication skills—able to convey complex clinical data with clarity and purpose to both scientific and non-scientific audiences.
Demonstrated problem-solving ability with urgency, focus, and creativity.
Proven record of building collaborative, high-performing teams and partnerships.
Highly organized, detail-oriented, and adaptable to fast-paced, evolving priorities.
Attributes
Strategic, decisive, and collaborative leader who inspires confidence and trust.
Strong communicator with credibility among internal teams and external stakeholders.
Relationship builder who thrives in a dynamic, mission-driven environment.
Committed to lifelong learning and continuous professional growth.
Base pay range for this position is expected to be
$315,000 - $350,000
annually, however the base pay offered may vary depending on location, market, job-related knowledge, skills, and capabilities, and experience. The total compensation package also includes equity, bonus, and benefits.
Equal Opportunity Employer We provide equal opportunity to all employees and applicants for employment and believe that great ideas and discoveries come from a mix of expertise, background, and experience. Olema is building a culture where the value of difference is celebrated. We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and give them a platform to develop their long-term careers. A Summary of Benefits is available for all applicants.
Fraud Alert We are aware of employment scams where individuals pose as representatives of Olema Oncology and use our company name to defraud job seekers. To protect yourself, please note that Olema’s official email addresses end in @olema.com. Our official corporate website is oleks.com; our careers page is olevs.com/careers; our LinkedIn page is linkedin.com/company/olema-oncology. Communication from any other variant is fraudulent. Olema does not conduct interviews via text message/messaging platforms, will not ask you to download anything as part of your interview, will never request any form of payment, provide upfront payments of any kind, and does not make job offers without an in-person interview.
#J-18808-Ljbffr
Olema Oncology is dedicated to developing better medicines for breast cancer and beyond. Our lead program, palazestrant (OP-1250), is a complete estrogen receptor antagonist currently in development for metastatic breast cancer with blockbuster potential as a monotherapy and in combination in ER+/HER2- metastatic breast cancer. Our follow-on product candidate, OP-3136, is a potent KAT6 inhibitor with best-in-class potential.
As the Senior Medical Director, reporting to the SVP of Clinical Development, you will serve as the Oncology Physician Lead for palazestrant and play a pivotal role in advancing Olema’s late-stage clinical pipeline.
This role may be based in either San Francisco, CA or Cambridge, MA and may require up to 20% travel.
Key Responsibilities
Lead registration-enabling studies for palazestrant in combination with other therapies, including study design, regulatory engagement, and investigator collaboration.
Partner across functions to define and implement clinical development strategies and plans for multiple programs.
Serve as the primary medical expert and point of contact for clinical and scientific questions across internal and external stakeholders.
Represent Olema in interactions with investigators, academic collaborators, thought leaders, and regulatory authorities.
Maintain strong clinical and scientific acumen through ongoing engagement with the oncology community and key scientific meetings.
Design and Deliver High-Impact Clinical Studies
Provide medical oversight and partner with CROs for Phase 3 programs and ensure alignment with Olema’s values, SOPs, and ethical standards.
Lead the development and execution of clinical protocols, amendments, investigator brochures, study reports, abstracts, and manuscripts.
Ensure scientific rigor and data integrity in partnership with cross-functional internal teams and CRO teams.
Evaluate safety, pharmacology, and efficacy data from ongoing and completed studies to inform program strategy and decision-making.
Contribute to regulatory submissions and communications.
Collaborate with preclinical and translational scientists to develop and integrate biomarker strategies.
Support data generation, publication planning, and external communication of study results.
Ideal Candidate Profile: Experienced Oncology Physician Leader You are an accomplished clinical development physician who thrives on meaningful, challenging work and is motivated by the opportunity to make a lasting impact on patients’ lives. You combine deep clinical and scientific expertise with strategic vision, collaboration, and a hands‑on approach to execution.
Knowledge
MD required.
Board certification in Oncology, Hematology/Oncology, or related specialty; significant experience in breast cancer may substitute.
5+ years of direct biotech or pharmaceutical experience in clinical development, with leadership in late-phase studies.
Strong understanding of breast cancer treatment paradigms; experience with ER+/HER2- disease preferred.
Experience
Proven success in designing, leading, and managing late-phase (registrational) studies in oncology; experience as a PI or academic breast cancer expert is also valued.
Deep understanding of the drug development process and ability to translate strategy into action—meeting milestones, managing budgets, and adapting to change.
Strong knowledge of GCP, FDA, and EMA/CHMP regulations; familiarity with other global regulatory standards is advantageous.
Effective leadership in a matrixed environment, influencing without authority and driving cross-functional alignment.
Exceptional communication skills—able to convey complex clinical data with clarity and purpose to both scientific and non-scientific audiences.
Demonstrated problem-solving ability with urgency, focus, and creativity.
Proven record of building collaborative, high-performing teams and partnerships.
Highly organized, detail-oriented, and adaptable to fast-paced, evolving priorities.
Attributes
Strategic, decisive, and collaborative leader who inspires confidence and trust.
Strong communicator with credibility among internal teams and external stakeholders.
Relationship builder who thrives in a dynamic, mission-driven environment.
Committed to lifelong learning and continuous professional growth.
Base pay range for this position is expected to be
$315,000 - $350,000
annually, however the base pay offered may vary depending on location, market, job-related knowledge, skills, and capabilities, and experience. The total compensation package also includes equity, bonus, and benefits.
Equal Opportunity Employer We provide equal opportunity to all employees and applicants for employment and believe that great ideas and discoveries come from a mix of expertise, background, and experience. Olema is building a culture where the value of difference is celebrated. We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and give them a platform to develop their long-term careers. A Summary of Benefits is available for all applicants.
Fraud Alert We are aware of employment scams where individuals pose as representatives of Olema Oncology and use our company name to defraud job seekers. To protect yourself, please note that Olema’s official email addresses end in @olema.com. Our official corporate website is oleks.com; our careers page is olevs.com/careers; our LinkedIn page is linkedin.com/company/olema-oncology. Communication from any other variant is fraudulent. Olema does not conduct interviews via text message/messaging platforms, will not ask you to download anything as part of your interview, will never request any form of payment, provide upfront payments of any kind, and does not make job offers without an in-person interview.
#J-18808-Ljbffr