Gilead Sciences
Sr Clinical Pharmacology Manager
Gilead Sciences, San Francisco, California, United States, 94199
About Gilead Sciences
Gilead is a global biopharmaceutical leader committed to creating a healthier world through science and innovation. For more than 35 years, we have tackled diseases such as HIV, viral hepatitis, COVID‑19, and cancer, working relentlessly to develop therapies that improve lives and to ensure access to these therapies across the globe. PBPK Scientist (Senior Clinical Manager)
As a PBPK expert, your main role will be to adapt, develop, and apply mechanistic physiology‑based pharmacokinetic (PBPK) models for both small and large molecule formats. These models will support key PK predictions for clinical pharmacology, including drug‑drug interactions, special population extrapolations, translational PK, PBPK‑PD, PBPK‑QSP, and regulatory submissions. Responsibilities
Develop PBPK models for small molecules and large molecule formats such as mAbs, bispecific Abs, ADCs, and other Ab constructs. Utilize existing PBPK frameworks (GastroPlus, Simcyp, PK‑Sim) where appropriate. Create minimal PBPK models and custom PBPK models using R and MATLAB as needed. Communicate regularly with cross‑functional teams to update modeling strategy and ensure timely execution of modeling goals. Present model findings to clinical teams and incorporate feedback. Provide expert guidance across teams as needed. Contribute to regulatory documents with reproducible documentation. Maintain accurate records of data, assumptions, parameter values, and model changes. Proactively identify opportunities to apply PBPK models to support portfolio and project needs. Author manuscripts describing model development and findings. Present modeling work externally at conferences and working groups. Serve as the PBPK subject matter expert to support Clinical Pharmacology with program‑specific questions. Basic Qualifications
8+ years with BS OR 6+ years with MS OR 2+ years with PhD/PharmD OR 0+ years with MD Preferred Qualifications
Proficiency in mathematical and computational skills needed for PBPK modeling work, including ordinary differential equations, linear algebra, statistics, optimization, and parameter inference. Expertise in at least one PBPK software package (GastroPlus, Simcyp, PK‑Sim). Proficiency in relevant software and programming languages (Python, R, C++, Julia, MATLAB, SimBiology). Basic understanding of molecular and cellular biology (immunology, oncology, virology, cellular signaling). Basic understanding of concepts of drug development. 3+ years of relevant experience and a PhD or PharmD degree. Experience with quantitative systems pharmacology (QSP) modeling. Experience with mechanistic PK/PD and compartmental PK/PD modeling. People Leader Accountabilities
Create inclusion by embedding diversity value in team management. Develop talent by coaching employees on current performance and future potential. Empower teams by aligning goals, purpose, and organizational objectives and holding them to account. Compensation
Base salary: $169,320.00 – $219,120.00. The position may also be eligible for a discretionary annual bonus, discretionary stock‑based long‑term incentives, paid time off, and a benefits package. Benefits
Company‑sponsored medical, dental, vision, and life insurance plans, paid time off, and other benefits. For additional benefits information, visit https://www.gilead.com/careers/compensation-benefits-and-wellbeing. Equal Employment Opportunity
Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other prohibited grounds specified in applicable federal, state and local laws. For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster.
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Gilead is a global biopharmaceutical leader committed to creating a healthier world through science and innovation. For more than 35 years, we have tackled diseases such as HIV, viral hepatitis, COVID‑19, and cancer, working relentlessly to develop therapies that improve lives and to ensure access to these therapies across the globe. PBPK Scientist (Senior Clinical Manager)
As a PBPK expert, your main role will be to adapt, develop, and apply mechanistic physiology‑based pharmacokinetic (PBPK) models for both small and large molecule formats. These models will support key PK predictions for clinical pharmacology, including drug‑drug interactions, special population extrapolations, translational PK, PBPK‑PD, PBPK‑QSP, and regulatory submissions. Responsibilities
Develop PBPK models for small molecules and large molecule formats such as mAbs, bispecific Abs, ADCs, and other Ab constructs. Utilize existing PBPK frameworks (GastroPlus, Simcyp, PK‑Sim) where appropriate. Create minimal PBPK models and custom PBPK models using R and MATLAB as needed. Communicate regularly with cross‑functional teams to update modeling strategy and ensure timely execution of modeling goals. Present model findings to clinical teams and incorporate feedback. Provide expert guidance across teams as needed. Contribute to regulatory documents with reproducible documentation. Maintain accurate records of data, assumptions, parameter values, and model changes. Proactively identify opportunities to apply PBPK models to support portfolio and project needs. Author manuscripts describing model development and findings. Present modeling work externally at conferences and working groups. Serve as the PBPK subject matter expert to support Clinical Pharmacology with program‑specific questions. Basic Qualifications
8+ years with BS OR 6+ years with MS OR 2+ years with PhD/PharmD OR 0+ years with MD Preferred Qualifications
Proficiency in mathematical and computational skills needed for PBPK modeling work, including ordinary differential equations, linear algebra, statistics, optimization, and parameter inference. Expertise in at least one PBPK software package (GastroPlus, Simcyp, PK‑Sim). Proficiency in relevant software and programming languages (Python, R, C++, Julia, MATLAB, SimBiology). Basic understanding of molecular and cellular biology (immunology, oncology, virology, cellular signaling). Basic understanding of concepts of drug development. 3+ years of relevant experience and a PhD or PharmD degree. Experience with quantitative systems pharmacology (QSP) modeling. Experience with mechanistic PK/PD and compartmental PK/PD modeling. People Leader Accountabilities
Create inclusion by embedding diversity value in team management. Develop talent by coaching employees on current performance and future potential. Empower teams by aligning goals, purpose, and organizational objectives and holding them to account. Compensation
Base salary: $169,320.00 – $219,120.00. The position may also be eligible for a discretionary annual bonus, discretionary stock‑based long‑term incentives, paid time off, and a benefits package. Benefits
Company‑sponsored medical, dental, vision, and life insurance plans, paid time off, and other benefits. For additional benefits information, visit https://www.gilead.com/careers/compensation-benefits-and-wellbeing. Equal Employment Opportunity
Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other prohibited grounds specified in applicable federal, state and local laws. For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster.
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