Summit Therapeutics, Inc.
Senior Medical Science Liaison
Summit Therapeutics, Inc. invites applications for the Senior Medical Science Liaison role.
About Summit Ivonescimab, known as SMT112, is a novel, potential first‑in‑class investigational bispecific antibody that combines the effects of PD‑1 blockade with anti‑angiogenesis via VEGF blocking within a single molecule. Ivonescimab displays unique cooperative binding to each of its intended targets, achieving a considerably higher affinity when both PD‑1 and VEGF are present. Summit is conducting clinical development of ivonescimab in non‑small cell lung cancer (NSCLC), with three active Phase III trials:
HARMONi – evaluates ivonescimab combined with chemotherapy versus placebo plus chemotherapy in EGFR‑mutated, locally advanced or metastatic non‑squamous NSCLC patients who progressed after third‑generation EGFR TKI (e.g., osimertinib).
HARMONi‑3 – compares ivonescimab plus chemotherapy with pembrolizumab plus chemotherapy in first‑line metastatic NSCLC.
HARMONi‑7 – compares ivonescimab monotherapy with pembrolizumab monotherapy in first‑line metastatic NSCLC patients with high PD‑L1 expression.
Ivonescimab is investigational and not yet approved by any regulatory authority in Summit’s license territories, excluding the United States and Europe. It received marketing authorization in China in May 2024 and Fast Track designation by the FDA for the HARMONi clinical trial setting.
Overview Of Role The Senior Medical Science Liaison is a field‑based scientific expert who strategically supports the scientific and business objectives of cancer therapeutic areas across the product life cycle. MSLs are the primary communicators of Summit’s science within a specific geography with healthcare professionals, focusing on Immuno‑Oncology and treatment options. They combine strong business acumen, clinical expertise, market awareness, and serve as a conduit of information to a cross‑functional customer base internally. Depending on therapeutic needs and product life cycles, teams may prioritize responsibilities such as clinical development and pipeline support.
Role And Responsibilities
Develop, execute, and maintain high‑impact territory plans, including HCP and investigator engagement strategies aligned with therapeutic‑area medical and scientific objectives, emphasizing quality.
Support clinical development and research initiatives across development, addressing requests from R&D including site evaluation, recruitment, investigator meetings, external expert identification, and facilitating investigator‑sponsored trials.
Identify, gain access to, and develop professional, customer‑centric relationships with external experts in Immuno‑Oncology within the assigned geography.
Provide education on disease state, therapeutic landscape, and Summit products throughout the product lifecycle to healthcare providers and researchers.
Participate in, monitor, and provide insights to Summit from relevant scientific meetings in the assigned geography.
Continuously maintain self‑education on market issues, product knowledge, and new therapeutic areas relevant to business responsibilities, creating awareness and relationships for Summit within the medical community.
Actively engage in relevant team meetings, organizational activities, and country‑driven medical affairs activities (e.g., advisory boards, masterclasses, roundtables).
Create, maintain, and collaborate on relationships with cross‑functional partners to develop and execute account plans that support shared scientific or business objectives.
Perform all other duties as assigned.
Experience, Education And Specialized Knowledge And Skills
Doctoral degree in the health sciences from an accredited university (MD, PhD, PharmD, or equivalent). Significant clinical and/or industry experience in oncology may be accepted in lieu of the education requirement.
Minimum of 5+ years of solid‑tumor cancer experience.
Minimum of 5+ years of clinical, scientific/research, or industry‑related experience.
Minimum of 2+ years’ experience in a Medical Science Liaison role.
Prior pharmaceutical industry experience within the relevant scientific discipline is strongly preferred.
Demonstrated past achievements in:
Understanding, analyzing, and communicating complex scientific concepts and data.
Building credible relationships with prominent HCPs.
Independently identifying and translating corporate needs into actionable plans that achieve objectives.
Self‑motivation to exceed goals.
Problem‑solving and analytic skills.
Critical thinking.
Independent work.
HCIR credentialing requirements to gain entry into facilities and organizations in the assigned territory, including background checks, drug screens, and proof of immunizations.
Additional requirements:
Willingness to travel up to 75% of the time.
Proficient in MS Office suite and electronic document management systems.
Strong computer and database skills.
Attention to detail, accuracy, and confidentiality.
Clear and concise oral and written communication skills.
Excellent organizational skills.
Ability to multi‑task and manage time‑sensitive, confidential documents.
Prioritization of conflicting demands.
Work in a fast‑paced, demanding, collaborative environment.
The pay range for this role is $200,000–$235,000 annually. Compensation packages are based on individual skill set, experience, certifications, and work location. The total compensation may also include bonus, stock, benefits, and other variable compensation.
Summit does not accept referrals from employment businesses and/or employment agencies for the vacancies posted on this site. All employment agencies are required to contact Summit’s Talent Acquisition team at recruiting@smmttx.com to obtain prior written authorization before referring candidates.
Seniority level: Mid‑Senior level | Employment type: Full‑time | Job function: Strategy/Planning and Information Technology.
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About Summit Ivonescimab, known as SMT112, is a novel, potential first‑in‑class investigational bispecific antibody that combines the effects of PD‑1 blockade with anti‑angiogenesis via VEGF blocking within a single molecule. Ivonescimab displays unique cooperative binding to each of its intended targets, achieving a considerably higher affinity when both PD‑1 and VEGF are present. Summit is conducting clinical development of ivonescimab in non‑small cell lung cancer (NSCLC), with three active Phase III trials:
HARMONi – evaluates ivonescimab combined with chemotherapy versus placebo plus chemotherapy in EGFR‑mutated, locally advanced or metastatic non‑squamous NSCLC patients who progressed after third‑generation EGFR TKI (e.g., osimertinib).
HARMONi‑3 – compares ivonescimab plus chemotherapy with pembrolizumab plus chemotherapy in first‑line metastatic NSCLC.
HARMONi‑7 – compares ivonescimab monotherapy with pembrolizumab monotherapy in first‑line metastatic NSCLC patients with high PD‑L1 expression.
Ivonescimab is investigational and not yet approved by any regulatory authority in Summit’s license territories, excluding the United States and Europe. It received marketing authorization in China in May 2024 and Fast Track designation by the FDA for the HARMONi clinical trial setting.
Overview Of Role The Senior Medical Science Liaison is a field‑based scientific expert who strategically supports the scientific and business objectives of cancer therapeutic areas across the product life cycle. MSLs are the primary communicators of Summit’s science within a specific geography with healthcare professionals, focusing on Immuno‑Oncology and treatment options. They combine strong business acumen, clinical expertise, market awareness, and serve as a conduit of information to a cross‑functional customer base internally. Depending on therapeutic needs and product life cycles, teams may prioritize responsibilities such as clinical development and pipeline support.
Role And Responsibilities
Develop, execute, and maintain high‑impact territory plans, including HCP and investigator engagement strategies aligned with therapeutic‑area medical and scientific objectives, emphasizing quality.
Support clinical development and research initiatives across development, addressing requests from R&D including site evaluation, recruitment, investigator meetings, external expert identification, and facilitating investigator‑sponsored trials.
Identify, gain access to, and develop professional, customer‑centric relationships with external experts in Immuno‑Oncology within the assigned geography.
Provide education on disease state, therapeutic landscape, and Summit products throughout the product lifecycle to healthcare providers and researchers.
Participate in, monitor, and provide insights to Summit from relevant scientific meetings in the assigned geography.
Continuously maintain self‑education on market issues, product knowledge, and new therapeutic areas relevant to business responsibilities, creating awareness and relationships for Summit within the medical community.
Actively engage in relevant team meetings, organizational activities, and country‑driven medical affairs activities (e.g., advisory boards, masterclasses, roundtables).
Create, maintain, and collaborate on relationships with cross‑functional partners to develop and execute account plans that support shared scientific or business objectives.
Perform all other duties as assigned.
Experience, Education And Specialized Knowledge And Skills
Doctoral degree in the health sciences from an accredited university (MD, PhD, PharmD, or equivalent). Significant clinical and/or industry experience in oncology may be accepted in lieu of the education requirement.
Minimum of 5+ years of solid‑tumor cancer experience.
Minimum of 5+ years of clinical, scientific/research, or industry‑related experience.
Minimum of 2+ years’ experience in a Medical Science Liaison role.
Prior pharmaceutical industry experience within the relevant scientific discipline is strongly preferred.
Demonstrated past achievements in:
Understanding, analyzing, and communicating complex scientific concepts and data.
Building credible relationships with prominent HCPs.
Independently identifying and translating corporate needs into actionable plans that achieve objectives.
Self‑motivation to exceed goals.
Problem‑solving and analytic skills.
Critical thinking.
Independent work.
HCIR credentialing requirements to gain entry into facilities and organizations in the assigned territory, including background checks, drug screens, and proof of immunizations.
Additional requirements:
Willingness to travel up to 75% of the time.
Proficient in MS Office suite and electronic document management systems.
Strong computer and database skills.
Attention to detail, accuracy, and confidentiality.
Clear and concise oral and written communication skills.
Excellent organizational skills.
Ability to multi‑task and manage time‑sensitive, confidential documents.
Prioritization of conflicting demands.
Work in a fast‑paced, demanding, collaborative environment.
The pay range for this role is $200,000–$235,000 annually. Compensation packages are based on individual skill set, experience, certifications, and work location. The total compensation may also include bonus, stock, benefits, and other variable compensation.
Summit does not accept referrals from employment businesses and/or employment agencies for the vacancies posted on this site. All employment agencies are required to contact Summit’s Talent Acquisition team at recruiting@smmttx.com to obtain prior written authorization before referring candidates.
Seniority level: Mid‑Senior level | Employment type: Full‑time | Job function: Strategy/Planning and Information Technology.
#J-18808-Ljbffr