Flagship Pioneering
ProFound Therapeutics, Inc. | Boston, MA (Senior) Scientist, Translatomics
Flagship Pioneering, Boston, Massachusetts, us, 02298
ProFound Therapeutics is pioneering the discovery of the expanded human proteome to unlock a new universe of potential therapeutics. By integrating multi-omics, advanced computation, and translational biology, we aim to reveal and characterize thousands of previously uncharted proteins and systematically explore their role in health and disease.
THE ROLE We are seeking a highly motivated (Senior) Scientist to join our growing translatomics team. In this role, you will lead experimental and analytical efforts at the intersection of RNA biology, translation, and sequencing technologies. You will design and conduct molecular biology experiments, run next‑generation sequencing (NGS) workflows on‑site, and analyze resulting data using Python, R, and bioinformatics tools. Working across early‑stage discovery programs, you will play a key role in developing and optimizing novel sequencing‑based assays – with a focus on translational regulation and ribosome profiling – to uncover insights that drive therapeutic innovation.
Key Responsibilities
Engage in early methods development and discovery projects that demand innovative, creative thinking, providing the opportunity to lead from conception through analysis.
Design and conduct molecular biology experiments in RNA biology and eukaryotic translation.
Analyze NGS data using bioinformatics software and existing pipelines.
Conduct additional sequencing data analysis in R or Python for specific queries beyond existing capabilities.
Effectively communicate, interpret, and present outcomes.
Keep precise records of protocols and experimental details in an electronic lab notebook.
Required Skills
Ph.D. in molecular biology, biochemistry, synthetic biology, or a related field, or equivalent experience and track record. A Ph.D. with 2+ years of industry or academic experience is preferred.
Extensive knowledge of RNA biology and eukaryotic translation mechanisms.
Practical experience with RNA workflows such as IVT, hybridization, and cell‑free translation.
Proficiency in RNA and DNA purification, qPCR, and cloning.
Experience with NGS, including sample handling and routine data analysis.
Experience with ribosome profiling is highly beneficial.
Proficiency in data visualization using Python or R.
Contributions to research articles and patents on custom sequencing‑based applications are highly advantageous.
VALUES & BEHAVIORS We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort working in and contributing to a dynamic and cross‑functional team environment. The level of the role will be commensurate with the education and years of experience of the identified candidate.
We recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and forward to learning more about your unique background.
ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID‑19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at
www.flagshippioneering.com .
At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.
Equal Opportunity Employer We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
The salary range for this role is $100,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. ProFound Therapeutics, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on ProFound Therapeutics, Inc.'s good faith estimate as of the date of publication and may be modified in the future.
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THE ROLE We are seeking a highly motivated (Senior) Scientist to join our growing translatomics team. In this role, you will lead experimental and analytical efforts at the intersection of RNA biology, translation, and sequencing technologies. You will design and conduct molecular biology experiments, run next‑generation sequencing (NGS) workflows on‑site, and analyze resulting data using Python, R, and bioinformatics tools. Working across early‑stage discovery programs, you will play a key role in developing and optimizing novel sequencing‑based assays – with a focus on translational regulation and ribosome profiling – to uncover insights that drive therapeutic innovation.
Key Responsibilities
Engage in early methods development and discovery projects that demand innovative, creative thinking, providing the opportunity to lead from conception through analysis.
Design and conduct molecular biology experiments in RNA biology and eukaryotic translation.
Analyze NGS data using bioinformatics software and existing pipelines.
Conduct additional sequencing data analysis in R or Python for specific queries beyond existing capabilities.
Effectively communicate, interpret, and present outcomes.
Keep precise records of protocols and experimental details in an electronic lab notebook.
Required Skills
Ph.D. in molecular biology, biochemistry, synthetic biology, or a related field, or equivalent experience and track record. A Ph.D. with 2+ years of industry or academic experience is preferred.
Extensive knowledge of RNA biology and eukaryotic translation mechanisms.
Practical experience with RNA workflows such as IVT, hybridization, and cell‑free translation.
Proficiency in RNA and DNA purification, qPCR, and cloning.
Experience with NGS, including sample handling and routine data analysis.
Experience with ribosome profiling is highly beneficial.
Proficiency in data visualization using Python or R.
Contributions to research articles and patents on custom sequencing‑based applications are highly advantageous.
VALUES & BEHAVIORS We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort working in and contributing to a dynamic and cross‑functional team environment. The level of the role will be commensurate with the education and years of experience of the identified candidate.
We recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and forward to learning more about your unique background.
ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID‑19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at
www.flagshippioneering.com .
At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.
Equal Opportunity Employer We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
The salary range for this role is $100,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. ProFound Therapeutics, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on ProFound Therapeutics, Inc.'s good faith estimate as of the date of publication and may be modified in the future.
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