Treeline
Associate Director/Director, Biochemistry
Overview We are seeking a highly motivated biochemist to join our drug discovery team in Watertown. The role involves designing and executing experiments to support early hit‑finding activities across 1‑2 programs simultaneously. Candidates should thrive in a laboratory setting and be eager to engage in mechanistic exploration, high‑throughput screens, hit‑finding, and lead‑optimization assays.
Responsibilities
Lead and execute mechanistic investigations of drug targets using kinetic, thermodynamic, and chemical biology approaches.
Build and use kinetic and mechanistic models to quantitatively predict and interpret experimental outcomes.
Integrate mechanistic data with structural biology, medicinal chemistry, and cell‑based readouts to prioritize follow‑up chemistry and propose assay and compound‑optimization strategies.
Design and implement robust assays for hit finding and high‑throughput screening, including primary biochemical assays and downstream assays for hit triage and binning.
Develop and maintain robust, high‑quality assays and SOPs; ensure reproducibility and rigorous data analysis.
Communicate findings clearly to colleagues and stakeholders through written reports and presentations to cross‑functional project teams.
Flexibly utilize the full breadth of your skills outside biochemistry to support projects.
Propose and evaluate new approaches and technologies.
Required Qualifications
Ph.D. in Biochemistry, Enzymology, Chemical Biology, Biophysics, or closely related discipline with 6+ years in biotech/pharma industry experience, or M.S. with 10+ years relevant industry experience.
Experience in small molecule drug discovery, specifically biochemical assay development and characterization of small molecule inhibitors and protein‑ligand binding interactions.
Training and hands‑on expertise in mechanistic enzymology, kinetics, binding assays, and mechanistic deconvolution with a proven track record of high‑impact applications to drug discovery.
Expertise deriving and validating mechanistic models based on a merger of biochemical, biophysical, and structural data including expertise with global fitting and kinetic and steady‑state modeling.
Track record of translating mechanistic insight into practical strategies for hit identification, hit triage, lead selection, SAR interpretation, or assay design.
Experience designing and optimizing a wide array of steady‑state and pre‑steady‑state biochemical assays, both enzymatic and binding, such as FP, TR‑FRET, and bead‑based assays.
Attention to detail and strong troubleshooting and problem‑solving skills.
Strong written and oral communication skills, excellent interpersonal skills, with demonstrated ability to work collaboratively on multidisciplinary teams.
Preferred Qualifications
Experience studying reversible and non‑reversible mechanisms, fragment‑based screening, and DEL.
Knowledge of automation and validation of assays for HTS.
Experience working with CROs.
Compensation & Benefits This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown, MA is $200,000 to $235,000. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the job, education, and other factors. Treeline Biosciences is a multi‑state employer, and this salary range may not reflect positions that work in other cities or states.
Recruitment Fraud Statement Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself: • Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline. • We do not conduct interviews through Skype or Telegram. • Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website. • You can find more information about job scams at consumer.ftc.gov/articles/job-scams. • To report job scams, head to ReportFraud.ftc.gov.
Employment Details Location: Watertown, MA Seniority level: Mid‑Senior level Employment type: Full‑time
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Overview We are seeking a highly motivated biochemist to join our drug discovery team in Watertown. The role involves designing and executing experiments to support early hit‑finding activities across 1‑2 programs simultaneously. Candidates should thrive in a laboratory setting and be eager to engage in mechanistic exploration, high‑throughput screens, hit‑finding, and lead‑optimization assays.
Responsibilities
Lead and execute mechanistic investigations of drug targets using kinetic, thermodynamic, and chemical biology approaches.
Build and use kinetic and mechanistic models to quantitatively predict and interpret experimental outcomes.
Integrate mechanistic data with structural biology, medicinal chemistry, and cell‑based readouts to prioritize follow‑up chemistry and propose assay and compound‑optimization strategies.
Design and implement robust assays for hit finding and high‑throughput screening, including primary biochemical assays and downstream assays for hit triage and binning.
Develop and maintain robust, high‑quality assays and SOPs; ensure reproducibility and rigorous data analysis.
Communicate findings clearly to colleagues and stakeholders through written reports and presentations to cross‑functional project teams.
Flexibly utilize the full breadth of your skills outside biochemistry to support projects.
Propose and evaluate new approaches and technologies.
Required Qualifications
Ph.D. in Biochemistry, Enzymology, Chemical Biology, Biophysics, or closely related discipline with 6+ years in biotech/pharma industry experience, or M.S. with 10+ years relevant industry experience.
Experience in small molecule drug discovery, specifically biochemical assay development and characterization of small molecule inhibitors and protein‑ligand binding interactions.
Training and hands‑on expertise in mechanistic enzymology, kinetics, binding assays, and mechanistic deconvolution with a proven track record of high‑impact applications to drug discovery.
Expertise deriving and validating mechanistic models based on a merger of biochemical, biophysical, and structural data including expertise with global fitting and kinetic and steady‑state modeling.
Track record of translating mechanistic insight into practical strategies for hit identification, hit triage, lead selection, SAR interpretation, or assay design.
Experience designing and optimizing a wide array of steady‑state and pre‑steady‑state biochemical assays, both enzymatic and binding, such as FP, TR‑FRET, and bead‑based assays.
Attention to detail and strong troubleshooting and problem‑solving skills.
Strong written and oral communication skills, excellent interpersonal skills, with demonstrated ability to work collaboratively on multidisciplinary teams.
Preferred Qualifications
Experience studying reversible and non‑reversible mechanisms, fragment‑based screening, and DEL.
Knowledge of automation and validation of assays for HTS.
Experience working with CROs.
Compensation & Benefits This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown, MA is $200,000 to $235,000. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the job, education, and other factors. Treeline Biosciences is a multi‑state employer, and this salary range may not reflect positions that work in other cities or states.
Recruitment Fraud Statement Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself: • Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline. • We do not conduct interviews through Skype or Telegram. • Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website. • You can find more information about job scams at consumer.ftc.gov/articles/job-scams. • To report job scams, head to ReportFraud.ftc.gov.
Employment Details Location: Watertown, MA Seniority level: Mid‑Senior level Employment type: Full‑time
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