BIOGIPUZKOA HEALTH RESEARCH INSTITUTE
EU Marie Curie funded pre-doctoral position (DC1: An integrated multi-omic and s
BIOGIPUZKOA HEALTH RESEARCH INSTITUTE, Villa Espana Colonia, Texas, United States
Organisation/Company BIOGIPUZKOA HEALTH RESEARCH INSTITUTE Research Field Biological sciences » Other Researcher Profile First Stage Researcher (R1) Positions PhD Positions Country Spain Application Deadline 31 Jan 2026 - 23:59 (Europe/Madrid) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Dec 2025 Is the job funded through the EU Research Framework Programme? Horizon Europe - MSCA Is the Job related to staff position within a Research Infrastructure? No
Offer Description The INT2ACT project ( https://int2act.eu/ ) –
Innovative Nucleic Acids Technologies for Analysis, Detection and Treatment
– is Doctoral Network (DN) supported by the European Union’s Marie Skłodowska-Curie Actions programme. This is one (DC1) of 15 doctoral projects within the INT2ACT project based in the
Molecular Oncology
group of Biogipuzkoa Health Research Institute in Donostia-San Sebastián.
This project is carried out in collaboration with the following groups and visits to their laboratories are expected during the project; Prof. Lei Zhang,
Sino-Swiss Institute for Advanced Technology (SSIAT),
Shanghai University, China and Dr. Marc Weber,
Flomics Biotech SL , Barcelona, Spain.
DUTIES AND RESPONSIBILITIES:
Project description:CAR-T
therapy has transformed the treatment of patients with relapsed or refractory B‑cell lymphomas. However, resistance and toxicities such as cytokine release syndrome and neurotoxicity limit its broader application. This creates a clinical need for biomarkers to better identify and manage toxicities, as well as to monitor disease progression. While previous projects have used genomic or transcriptomic approaches to study biomarkers in CAR‑T patients, these have typically relied on a single “omic” method and small patient cohorts. The aim of this project
(BIOCART)
is to identify new blood‑based biomarkers in CAR‑T‑treated patients through a prospective, international, multicenter study using a comprehensive multi‑omics strategy (cfDNA, miRNA, methylomics, glycomics, and spectroscopy). Blood samples are collected from patients treated with axi‑cel, with blood drawn before leukapheresis, at days 2, 4, 6, 8, and 10 post‑infusion, and again at 3, 6, and 12 months. The resulting omic data will be used to develop and train novel machine‑learning pipelines capable of integrating and harmonizing multi‑omics datasets in order to identify biomarkers of (1) early treatment response, (2) disease progression, and (3) therapy‑related toxicities. The resulting algorithm and biomarkers will then be tested in an independent validation cohort of 120 patients. This PhD project will focus on the bioinformatics analyses of data from the multiple‑techniques, fusion of this data and development of new computational tools to analyse and harmonise data.
Bioinformatics and/or computational biology experience (e.g. through Master thesis work or research internships) with large‑scale omics datasets.
Intermediate level in at least one programming language (Python, R, C++) and basic knowledge of machine‑learning and/or deep‑learning algorithms.
Proficiency in the English language is required, as well as good communication skills, both oral and written.
Specific Requirements
Eligibility conditions:
Master’s degree in Bioinformatics, Computational Biology, Mathematics, Biotechnology or related field.
Applicants must be doctoral candidates, i.e not already in possession of a doctoral degree.
Mobility rule: researchers must not have resided or carried out their main activity in Spain for more than 12 months in the 36 months immediately before their recruitment date .
*A disability certificate of 33% or higher is a plus.
Languages ENGLISH Level Excellent
Internal Application form(s) needed
Application Manual for Employment Offers of the Biogipuzkoa Health Research Institute_0.pdf
TYPE OF CONTRACT (LEGAL REFERENCE): One-year trainee predoctoral researcher contract available, extendable to a maximum of 48 months (one‑year extension).
WORK SCHEDULE: Full‑time
EXPECTED START DATE: Second quarter of the year 2026 (Q2)
ANNUAL GROSS SALARY: €26,900 per year (gross)
The worker must comply with the operating rules set by the Biogipuzkoa Institute in terms of commitment, duties, working hours, leave entitlements, etc.
Eligibility criteria
EVALUATION (MAXIMUM OF 100 POINTS WITHOUT AN INTERVIEW AND 125 POINTS WITH AN INTERVIEW)
Only applications that meet the ESSENTIAL competencies in the offer shall be taken into account.
EXPERIENCE (0-65 POINTS)
PROVEN LANGUAGE SKILLS (0-10 POINTS)
OTHER DISTINCTIONS (0-15 POINTS)
CERTIFICATE VERIFYING A MINIMUM DISABILITY OF 33% (0-10 POINTS)
BIOGIPUZKOA is committed to the principles of open, transparent and merit‑based recruitment (OTM‑R policy), in accordance with the requirements of the HRS4R seal established by European Commission.
As such, it takes responsibility for ensuring gender equality based on the goals established in the current Gender Equality Plan.
Once the evaluation and selection have been conducted, candidates may request information on their scores, as well as the score of the selected candidate.
CV submission deadline: The closing date for applications is January 31 2026.
#J-18808-Ljbffr
Offer Description The INT2ACT project ( https://int2act.eu/ ) –
Innovative Nucleic Acids Technologies for Analysis, Detection and Treatment
– is Doctoral Network (DN) supported by the European Union’s Marie Skłodowska-Curie Actions programme. This is one (DC1) of 15 doctoral projects within the INT2ACT project based in the
Molecular Oncology
group of Biogipuzkoa Health Research Institute in Donostia-San Sebastián.
This project is carried out in collaboration with the following groups and visits to their laboratories are expected during the project; Prof. Lei Zhang,
Sino-Swiss Institute for Advanced Technology (SSIAT),
Shanghai University, China and Dr. Marc Weber,
Flomics Biotech SL , Barcelona, Spain.
DUTIES AND RESPONSIBILITIES:
Project description:CAR-T
therapy has transformed the treatment of patients with relapsed or refractory B‑cell lymphomas. However, resistance and toxicities such as cytokine release syndrome and neurotoxicity limit its broader application. This creates a clinical need for biomarkers to better identify and manage toxicities, as well as to monitor disease progression. While previous projects have used genomic or transcriptomic approaches to study biomarkers in CAR‑T patients, these have typically relied on a single “omic” method and small patient cohorts. The aim of this project
(BIOCART)
is to identify new blood‑based biomarkers in CAR‑T‑treated patients through a prospective, international, multicenter study using a comprehensive multi‑omics strategy (cfDNA, miRNA, methylomics, glycomics, and spectroscopy). Blood samples are collected from patients treated with axi‑cel, with blood drawn before leukapheresis, at days 2, 4, 6, 8, and 10 post‑infusion, and again at 3, 6, and 12 months. The resulting omic data will be used to develop and train novel machine‑learning pipelines capable of integrating and harmonizing multi‑omics datasets in order to identify biomarkers of (1) early treatment response, (2) disease progression, and (3) therapy‑related toxicities. The resulting algorithm and biomarkers will then be tested in an independent validation cohort of 120 patients. This PhD project will focus on the bioinformatics analyses of data from the multiple‑techniques, fusion of this data and development of new computational tools to analyse and harmonise data.
Bioinformatics and/or computational biology experience (e.g. through Master thesis work or research internships) with large‑scale omics datasets.
Intermediate level in at least one programming language (Python, R, C++) and basic knowledge of machine‑learning and/or deep‑learning algorithms.
Proficiency in the English language is required, as well as good communication skills, both oral and written.
Specific Requirements
Eligibility conditions:
Master’s degree in Bioinformatics, Computational Biology, Mathematics, Biotechnology or related field.
Applicants must be doctoral candidates, i.e not already in possession of a doctoral degree.
Mobility rule: researchers must not have resided or carried out their main activity in Spain for more than 12 months in the 36 months immediately before their recruitment date .
*A disability certificate of 33% or higher is a plus.
Languages ENGLISH Level Excellent
Internal Application form(s) needed
Application Manual for Employment Offers of the Biogipuzkoa Health Research Institute_0.pdf
TYPE OF CONTRACT (LEGAL REFERENCE): One-year trainee predoctoral researcher contract available, extendable to a maximum of 48 months (one‑year extension).
WORK SCHEDULE: Full‑time
EXPECTED START DATE: Second quarter of the year 2026 (Q2)
ANNUAL GROSS SALARY: €26,900 per year (gross)
The worker must comply with the operating rules set by the Biogipuzkoa Institute in terms of commitment, duties, working hours, leave entitlements, etc.
Eligibility criteria
EVALUATION (MAXIMUM OF 100 POINTS WITHOUT AN INTERVIEW AND 125 POINTS WITH AN INTERVIEW)
Only applications that meet the ESSENTIAL competencies in the offer shall be taken into account.
EXPERIENCE (0-65 POINTS)
PROVEN LANGUAGE SKILLS (0-10 POINTS)
OTHER DISTINCTIONS (0-15 POINTS)
CERTIFICATE VERIFYING A MINIMUM DISABILITY OF 33% (0-10 POINTS)
BIOGIPUZKOA is committed to the principles of open, transparent and merit‑based recruitment (OTM‑R policy), in accordance with the requirements of the HRS4R seal established by European Commission.
As such, it takes responsibility for ensuring gender equality based on the goals established in the current Gender Equality Plan.
Once the evaluation and selection have been conducted, candidates may request information on their scores, as well as the score of the selected candidate.
CV submission deadline: The closing date for applications is January 31 2026.
#J-18808-Ljbffr