Engage Bio
Scientist / Sr. Scientist - Genetic Medicine R&D
Engage Bio, San Carlos, California, United States, 94071
Scientist / Sr. Scientist - Genetic Medicine R&D
Scientist / Sr. Scientist - Genetic Medicine R&D
This range is provided by Engage Bio. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more. Base pay range
$100,000.00/yr - $150,000.00/yr Additional compensation types
Annual Bonus and Stock options Engage Bio is redefining what’s possible in genetic medicine. Our proprietary
Tethosome platform
overcomes the two biggest barriers to non-viral DNA therapies: insufficient expression and cytoplasmic DNA-driven toxicity. Tethosomes achieve
>100-fold increased expression
relative to conventional DNA vectors while evading innate immune detection, combining the
potency of mRNA
with the long-term
durability of DNA . A single dose of our therapies has the potential to turn tissues of the body (for example the liver or the lung) into factories for protein therapeutics - with the potential for
years of expression , and unlike viral therapies, we have the ability to
redose when needed . We're advancing treatments across a broad spectrum of diseases: from
ultra-rare genetic disorders
to common
chronic conditions
that affect millions. The Opportunity We’re looking for a highly motivated
Scientist
to support our R&D team across key preclinical research activities. Your primary initial focus will be the
optimization, production and chromatographic purification
of Tethosome nucleic acids, but you’ll also have the opportunity to contribute broadly across molecular biology, cell biology, and platform development efforts. This is an excellent opportunity to gain broad exposure to
early-stage biotech R&D , spanning projects from early concept through IND-enabling studies. What You'll Do Lead efforts to optimize, produce and purify Tethosome nucleic acids at research scale, large animal toxicity study scale, and beyond Develop and optimize chromatographic workflows for nucleic acid purification Design and execute molecular biology and assay-based experiments to support platform innovation Deliver high-quality data packages to inform decision-making across the R&D team Contribute to new assay development, protocol optimization, and exploratory technology evaluations Collaborate across functions and bring a generalist mindset to dynamic project needs Who You Are PhD in Molecular Biology
or a related field. Recent graduates are welcome, as are those with relevant postdoctoral or industry experience Candidates with expertise in purifying other biomolecules, or those with a strong generalist background in molecular biology, will also be considered (particularly those with a demonstrated ability to adapt quickly and solve technical challenges) Valuable Skills Molecular cloning (e.g., Gibson or Golden Gate assembly) Mammalian cell culture and transfection Bacterial fermentation optimization High-throughput assays (96- or 384-well formats) Working in fast-moving R&D teams with rapidly evolving priorities Clear written and verbal scientific communication Writing protocols/reports/SOPs Collaborating across disciplines while driving independent contributions We’re looking for someone to help us maintain (and accelerate!) our fast-paced work. This will be a predominantly lab-based position and will require the candidate to be on-site full-time. We have an amazing space at MBC Biolabs, San Carlos (https://mbcbiolabs.com), which features: State of the art scientific instruments Fully stocked kitchen + regular catered talks/events; team lunches twice a week Dynamic community of biotech innovators (and ping pong tournaments!) $100-150,000 base salary per year (title and salary depending on experience level) Significant equity compensation Performance-based bonus Full Health, Dental, and Vision insurance Join Us We’re a mission-driven team working to eliminate human disease. If you’re ready to contribute to high-impact science, push technical boundaries, and grow with an ambitious early-stage company, we’d love to meet you. Please note: Engage Bio is hiring for multiple Scientist positions. If you have applied in the past month, please do not submit another application; we will review your application and reach out shortly if you are a good fit for any of our open positions. Thank you. Seniority level
Seniority level Entry level Employment type
Employment type Full-time Job function
Job function Research, Analyst, and Information Technology Referrals increase your chances of interviewing at Engage Bio by 2x Get notified about new Senior Scientist jobs in
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Scientist / Sr. Scientist - Genetic Medicine R&D
This range is provided by Engage Bio. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more. Base pay range
$100,000.00/yr - $150,000.00/yr Additional compensation types
Annual Bonus and Stock options Engage Bio is redefining what’s possible in genetic medicine. Our proprietary
Tethosome platform
overcomes the two biggest barriers to non-viral DNA therapies: insufficient expression and cytoplasmic DNA-driven toxicity. Tethosomes achieve
>100-fold increased expression
relative to conventional DNA vectors while evading innate immune detection, combining the
potency of mRNA
with the long-term
durability of DNA . A single dose of our therapies has the potential to turn tissues of the body (for example the liver or the lung) into factories for protein therapeutics - with the potential for
years of expression , and unlike viral therapies, we have the ability to
redose when needed . We're advancing treatments across a broad spectrum of diseases: from
ultra-rare genetic disorders
to common
chronic conditions
that affect millions. The Opportunity We’re looking for a highly motivated
Scientist
to support our R&D team across key preclinical research activities. Your primary initial focus will be the
optimization, production and chromatographic purification
of Tethosome nucleic acids, but you’ll also have the opportunity to contribute broadly across molecular biology, cell biology, and platform development efforts. This is an excellent opportunity to gain broad exposure to
early-stage biotech R&D , spanning projects from early concept through IND-enabling studies. What You'll Do Lead efforts to optimize, produce and purify Tethosome nucleic acids at research scale, large animal toxicity study scale, and beyond Develop and optimize chromatographic workflows for nucleic acid purification Design and execute molecular biology and assay-based experiments to support platform innovation Deliver high-quality data packages to inform decision-making across the R&D team Contribute to new assay development, protocol optimization, and exploratory technology evaluations Collaborate across functions and bring a generalist mindset to dynamic project needs Who You Are PhD in Molecular Biology
or a related field. Recent graduates are welcome, as are those with relevant postdoctoral or industry experience Candidates with expertise in purifying other biomolecules, or those with a strong generalist background in molecular biology, will also be considered (particularly those with a demonstrated ability to adapt quickly and solve technical challenges) Valuable Skills Molecular cloning (e.g., Gibson or Golden Gate assembly) Mammalian cell culture and transfection Bacterial fermentation optimization High-throughput assays (96- or 384-well formats) Working in fast-moving R&D teams with rapidly evolving priorities Clear written and verbal scientific communication Writing protocols/reports/SOPs Collaborating across disciplines while driving independent contributions We’re looking for someone to help us maintain (and accelerate!) our fast-paced work. This will be a predominantly lab-based position and will require the candidate to be on-site full-time. We have an amazing space at MBC Biolabs, San Carlos (https://mbcbiolabs.com), which features: State of the art scientific instruments Fully stocked kitchen + regular catered talks/events; team lunches twice a week Dynamic community of biotech innovators (and ping pong tournaments!) $100-150,000 base salary per year (title and salary depending on experience level) Significant equity compensation Performance-based bonus Full Health, Dental, and Vision insurance Join Us We’re a mission-driven team working to eliminate human disease. If you’re ready to contribute to high-impact science, push technical boundaries, and grow with an ambitious early-stage company, we’d love to meet you. Please note: Engage Bio is hiring for multiple Scientist positions. If you have applied in the past month, please do not submit another application; we will review your application and reach out shortly if you are a good fit for any of our open positions. Thank you. Seniority level
Seniority level Entry level Employment type
Employment type Full-time Job function
Job function Research, Analyst, and Information Technology Referrals increase your chances of interviewing at Engage Bio by 2x Get notified about new Senior Scientist jobs in
San Carlos, CA . Science Manager - Dynamic Pricing (Surge)
San Francisco, CA $212,000.00-$235,500.00 1 month ago Santa Clara, CA $138,960.00-$231,600.00 3 months ago San Jose, CA $98,700.00-$183,300.00 1 week ago Hayward, CA $85,000.00-$110,000.00 1 month ago Senior Product/Process Development Scientist - Clorox Professional
Senior Scientist - Cardiometabolic Disorders
Senior Scientist - Cardiometabolic Disorders
Senior Machine Learning Scientist, NLP/LLM
Hayward, CA $70,000.00-$85,000.00 9 months ago Principal Scientist, IVD Product Development
South San Francisco, CA $180,000.00-$200,000.00 1 month ago Fremont, CA $140,000.00-$160,000.00 1 week ago We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
#J-18808-Ljbffr