SRT Therapeutics Inc.
Position Summary
SRT Therapeutics is a San Diego-based biotech company established in 2024 by the founders of Prometheus Biosciences. Building on the success of precision medicine in IBD with Tulisokibart (MK7240), SRT Therapeutics will expand this approach by targeting key pathways that modulate inflammatory pathways and promote tissue healing in IBD, enhancing both outcomes and the quality of care for patients.
Senior Scientist – Predictive and Translational Biomarkers
We are seeking a highly motivated and technically proficient Senior Scientist to join our Predictive and Translational Biomarkers team. The ideal candidate will have extensive hands‑on expertise in designing, executing, and analyzing complex experiments relevant to immunology, be driven to generate high‑quality mechanistic data, and provide deep biological insight into pipeline programs. This cross‑functional position will support multi‑omic data generation to enable precision medicine and develop translational biomarker assays to support IND‑enabling work.
Beyond technical expertise, the candidate will collaborate effectively with internal teams and external partners, ensuring projects stay on track to support the company’s innovation pipeline. This role requires a proactive, solutions‑oriented approach, the ability to adapt to evolving priorities in a fast‑paced environment.
Responsibilities
Design, develop, and execute complex primary functional assays to assess drug mechanism of action (MoA) and advance multi‑omic strategy for predictive biomarker discovery.
Design, optimize, and validate high‑parameter immunophenotyping panels for immune cell characterization from patient samples.
Develop translational biomarker assays including target engagement, receptor occupancy, and pharmacodynamic endpoints to support IND‑enabling studies and early clinical development.
Perform high‑quality data analysis, interpretation, and rigorous documentation of experimental results in ELNs and technical reports.
Contribute scientifically to project team discussions by providing insights and proposing clear, feasible, and robust laboratory experimental plans to address major questions.
Collaborate closely with Computational Biology and Biobanking groups to ensure generated data is standardized, of high quality, and organized appropriately to support predictive biomarker discovery.
Qualifications, Education, and Experience
PhD or equivalent experience in Immunology, Cell Biology, or a closely related field with 5+ years of industry or mixed academic/industry experience in immunology, drug discovery, or translational research.
Extensive hands‑on expertise in immunology lab techniques, including demonstrated ability to isolate, culture, and characterize primary human immune cells and tissue.
Deep technical proficiency in advanced multi‑color flow cytometry (panel design, optimization, acquisition, and analysis using software such as FlowJo).
Demonstrated experience in primary cell functional assay development relevant to inflammatory/autoimmune disease.
Prior experience in the development or technical execution of assays for translational biomarkers (e.g., pharmacodynamic endpoints, target engagement, receptor occupancy).
Proven ability to work independently and efficiently in a laboratory setting, manage time effectively, and troubleshoot complex technical issues.
Strong communication skills, with the ability to clearly present detailed laboratory findings and proposed next steps to a scientific team.
Benefits
Competitive salary commensurate with experience ($120,000 - $160,000)
Health, dental, and vision insurance
Paid time off and company holidays
Bonus & Equity eligibility
Referrals increase your chances of interviewing at SRT Therapeutics Inc. by 2x. Get notified about new Senior Scientist jobs in San Diego, CA.
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Senior Scientist – Predictive and Translational Biomarkers
We are seeking a highly motivated and technically proficient Senior Scientist to join our Predictive and Translational Biomarkers team. The ideal candidate will have extensive hands‑on expertise in designing, executing, and analyzing complex experiments relevant to immunology, be driven to generate high‑quality mechanistic data, and provide deep biological insight into pipeline programs. This cross‑functional position will support multi‑omic data generation to enable precision medicine and develop translational biomarker assays to support IND‑enabling work.
Beyond technical expertise, the candidate will collaborate effectively with internal teams and external partners, ensuring projects stay on track to support the company’s innovation pipeline. This role requires a proactive, solutions‑oriented approach, the ability to adapt to evolving priorities in a fast‑paced environment.
Responsibilities
Design, develop, and execute complex primary functional assays to assess drug mechanism of action (MoA) and advance multi‑omic strategy for predictive biomarker discovery.
Design, optimize, and validate high‑parameter immunophenotyping panels for immune cell characterization from patient samples.
Develop translational biomarker assays including target engagement, receptor occupancy, and pharmacodynamic endpoints to support IND‑enabling studies and early clinical development.
Perform high‑quality data analysis, interpretation, and rigorous documentation of experimental results in ELNs and technical reports.
Contribute scientifically to project team discussions by providing insights and proposing clear, feasible, and robust laboratory experimental plans to address major questions.
Collaborate closely with Computational Biology and Biobanking groups to ensure generated data is standardized, of high quality, and organized appropriately to support predictive biomarker discovery.
Qualifications, Education, and Experience
PhD or equivalent experience in Immunology, Cell Biology, or a closely related field with 5+ years of industry or mixed academic/industry experience in immunology, drug discovery, or translational research.
Extensive hands‑on expertise in immunology lab techniques, including demonstrated ability to isolate, culture, and characterize primary human immune cells and tissue.
Deep technical proficiency in advanced multi‑color flow cytometry (panel design, optimization, acquisition, and analysis using software such as FlowJo).
Demonstrated experience in primary cell functional assay development relevant to inflammatory/autoimmune disease.
Prior experience in the development or technical execution of assays for translational biomarkers (e.g., pharmacodynamic endpoints, target engagement, receptor occupancy).
Proven ability to work independently and efficiently in a laboratory setting, manage time effectively, and troubleshoot complex technical issues.
Strong communication skills, with the ability to clearly present detailed laboratory findings and proposed next steps to a scientific team.
Benefits
Competitive salary commensurate with experience ($120,000 - $160,000)
Health, dental, and vision insurance
Paid time off and company holidays
Bonus & Equity eligibility
Referrals increase your chances of interviewing at SRT Therapeutics Inc. by 2x. Get notified about new Senior Scientist jobs in San Diego, CA.
#J-18808-Ljbffr