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Brigham and Women's Hospital

Clinical Research Assistant in Neuromodulation and Neuroimaging (CRISP study)

Brigham and Women's Hospital, Boston, Massachusetts, us, 02298

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The Holsen Lab in the Departments of Medicine and Psychiatry at Brigham and Women's Hospital/Harvard Medical School is seeking a full-time post-bac clinical research assistant with a strong interest in neuroscience, psychology, and quantitative methods, including data analysis or computer science. The individual will assist with a clinical trial using both neuromodulation (transcranial magnetic stimulation) and neuroimaging (fMRI) to validate a novel cerebellar satiety network in healthy adults. Under the supervision of Dr. Laura Holsen and a postdoctoral fellow, the post-bac clinical research assistant will carry out a broad range of neuroimaging, biostatistics, and computer science-based research activities and procedures as indicated below. This is a great position for those wanting clinical research experience before applying for graduate school or medical school. Our team has a strong track record of mentoring research assistants who have gone on to pursue medical school or doctoral programs in clinical psychology, cognitive neuroscience, neuroscience, public health, and bioinformatics. You can find out more about our lab at https://holsenlab.bwh.harvard.edu/.

Fostering diversity in the scientific research workforce is a key goal of Dr. Holsen and her team. Thus, additional support and mentorship are available for individuals from diverse backgrounds, including those from groups demonstrated to be underrepresented in the biomedical, behavioral, clinical, and social sciences.

Principal Duties and Responsibilities

Personal vehicle is required for this position.

Develop and implement strategies to recruit subjects to participate in clinical trials

Interview (prescreen) prospective volunteers, complete consenting procedures, conduct chart reviews, and determine their eligibility to participate in the study with guidance from study clinicians and PIs

Schedule and conduct study visits with subjects, including administering computerized questionnaires and tasks, collecting biological samples, and working alongside MRI techs to collect MRI data

Conduct structured clinical interviews for psychiatric disorders, including eating disorders, mood disorders, and suicidal ideation (training and supervision with clinical psychologist provided)

Review test results and data with the postdoctoral fellow and principal investigators to ensure that protocol requirements are met and that abnormalities are addressed by clinicians

Enter and maintain data collected from medical charts and study databases

Develop meeting agendas, present/guide discussion related to agenda topics, and document meeting notes

Complete applications, periodic reports, and related forms and ensure timely submission to regulatory bodies overseeing the clinical study

Contribute to the collection, coding, management, and analysis of behavioral data

DICOM unpacking, conversion of data to NIfTI (BIDS) format

Creation of bash and R scripts for data organization

Visual inspection of structural and functional data quality

Editing and running MATLAB-based SPM12 preprocessing scripts

Quality assessment of motion for functional data

Editing and running first- and second-level models in SPM12 and fMRIPrep

Additional Duties and Responsibilities

Create and maintain a variety of study related logs, including billing logs

Use software programs to generate statistical graphs and reports

Assist with formal audits of data and study documents

Assist with submitting IRB amendments and other study-related protocol updates

Assist with preparing abstracts and posters

Upload data to the NIH Data Archive

Prepare detailed agendas and data updates for meetings

Skills/Abilities/Competencies Required

Have a strong background and interest in neuroscience, cognitive neuroscience, psychology, biology, mathematics, statistics, or computer science

Be in good academic standing with a strong GPA

Strong computer and statistical skills

Programming skills (previous R experience is required)

Comfort with Linux environment

Experience working in REDCap

Experience using R, MATLAB, SPM12, and/or fMRIPrep

Careful attention to details

Good organizational and communication skills

Working knowledge of clinical research protocols

Ability to demonstrate respect and professionalism for subjects' rights and individual needs

Ability to work independently and as a team player

Analytical skills and ability to resolve technical problems

Ability to interpret acceptability of data results

Working knowledge of data management program

The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

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