Director, AI-Driven Molecule Discovery

Tonix is a fully integrated biotechnology company, publicly traded on NASDAQ (ticker: TNXP), with marketed products and a pipeline of development candidates. The Company is focused on commercializing, developing, discovering, and licensing therapeutics to treat and prevent human disease. In August 2025, Tonix received FDA approval for Tonmya™ (cyclobenzaprine HCl sublingual tablets), a first‑in‑class, once‑daily, non‑opioid treatment for fibromyalgia. Tonmya is the first new fibromyalgia therapy approved in over 15 years, following successful Phase 3 trials demonstrating significant symptom improvement. Commercial launch is expected in the fourth quarter of 2025. Tonix also markets Zembrace® SymTouch® (sumatriptan injection) 3 mg and Tosymra® (sumatriptan nasal spray) 10 mg, both indicated for the treatment of acute migraine with or without aura in adults. Tonix’s development portfolio includes product candidates in central nervous system (CNS), immunology, immuno‑oncology, infectious disease, and rare disease. The CNS pipeline features both small molecules and biologics to treat pain, neurologic, psychiatric, and addiction conditions. The immunology portfolio includes biologics to address organ transplant rejection, autoimmunity, and cancer. The infectious disease pipeline includes a vaccine in development to prevent smallpox and monkeypox, which also serves as a live virus vaccine platform for other infectious diseases. Finally, rare disease portfolio includes a product in development for Prader‑Willi syndrome, which has both orphan drug designation and rare pediatric disease designation grants from the FDA. Tonix owns and operates a state‑of‑the‑art infectious disease research facility in Frederick, Md. Please visit www.Tonixpharma.com for specifics on the pipeline. *All of Tonix’s product candidates are investigational new drugs or biologics and have not been approved for any indication. About the Role: The Director will lead the strategic development and application of artificial intelligence (AI) and computer‑aided drug design (CADD) to accelerate research and development at Tonix. This role will drive innovation across both small‑ and large‑molecule programs by integrating ligand‑ and structure‑based design with AI/ML to identify and optimize novel therapeutic candidates. The Director will collaborate with chemists, biologists, data scientists, and software engineers to develop data‑driven strategies to advance Tonix’s pipeline on CNS, rare disease, immunology, and infectious disease. The position will also help build scalable AI infrastructure to support informed decision‑making across Tonix’s discovery portfolio. The Director will ensure that AI and computational initiatives align with Tonix’s organizational goals and research priorities, delivering impactful results that support both preclinical research and long‑term development objectives. Key Responsibilities Define and implement Tonix’s computational and AI‑driven drug discovery strategy in alignment with company R&D priorities. Lead computational and AI‑enabled design initiatives to accelerate drug discovery and development. Develop and apply AI/CADD‑based approaches to target validation, hit‑to‑lead optimization, ADME/Tox profiling, and preclinical safety and efficacy assessment. Develop and integrate scalable AI/ML tools, data workflows, and high‑performance computing solutions to support Tonix’s discovery pipeline. Collaborate closely with chemists, biologists, pharmacologists, and informatics experts to translate computational insights into actionable experimental hypotheses. Contribute to publications, patents, and presentations that enhance Tonix’s scientific visibility in AI‑enabled drug discovery. Qualifications Ph.D. in Pharmacology, Chemistry, Structural Biology, or a related discipline. 20 years of experience in drug design and discovery, including leadership in developing and applying AI/CADD approaches to advance programs from concept to clinical stage. Ligand‑based drug design expertise: AI/ML, QSAR, neural networks, pharmacophore modeling, de novo design, virtual screening, and ADME/Tox modeling. Structure‑based drug design expertise: sequence analysis, protein modeling, molecular docking, AlphaFold, molecular dynamics simulations, and free energy perturbation. Proficiency with modern molecular modeling platforms, such as Schrödinger, MOE, AlphaFold, and AMBER. Experienced in AI/ML programming and data analysis, such as Python (Jupyter Notebook, Chemprop, RDKit, Scikit‑learn, NumPy, Pandas) and bash scripting. Strong understanding of CNS, pain biology, and translational pharmacology. Demonstrated ability to collaborate effectively in multidisciplinary settings and to communicate complex modeling results to non‑specialist teams. Experience managing collaborations with external chemistry partners and CROs. Proven leadership, project management, and mentorship capabilities. Salary range - $150k - $240k Recruitment & Staffing Agencies Tonix does not accept agency resumes unless contacted directly by internal Tonix Talent Acquisition. Please do not forward resumes to Tonix employees or any other company location; Tonix is not responsible for any fees related to unsolicited resumes. Tonix provides a comprehensive compensation and benefits package which includes: Medical, Dental & Vision Insurance, Basic and Voluntary Life and AD&D Insurance, Short‑ and Long‑Term Disability Insurance, Flexible Spending Accounts, Health Savings Account, and Employee Assistance Programs Pet Insurance Retirement Savings 401k with company match and annual discretionary stock options Generous Paid Time Off, Sick Time, & Paid Holidays Career Development and Training Tonix provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, genetics, or any other characteristic protected by law. In addition to federal law requirements, Tonix complies with applicable state and local laws governing nondiscrimination in employment. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfers, leaves of absence, compensation, and training. Tonix expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic, information, disability, veteran status, or any other characteristic protected by law.

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