Treeline
Senior Scientist, Mass Spectrometry Technologies
Treeline, San Diego, California, United States, 92189
Senior Scientist, Mass Spectrometry Technologies
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Senior Scientist, Mass Spectrometry Technologies
role at
Treeline
Treeline Biosciences is an innovative biotechnology company, founded by an experienced team of biopharmaceutical scientists and executives, committed to developing new medicines against difficult to drug targets in cancer and other life‑threatening diseases. We are pursuing a uniquely integrated approach that applies modern and emerging tools in genomics, lead discovery, medicinal chemistry, and computation to reduce the time and risks of drug discovery.
About the Role We are seeking an experienced, enthusiastic, and highly motivated senior scientist to join our Mass Spectrometry Technologies group in San Diego, CA to deliver high-quality scientific data and drive small molecule drug discovery. The candidate will be part of a larger mass spectrometry team focused in part on applying and developing proteomics approaches to support early and later stage drug‑discovery. The successful candidate will be a critical collaborator within the multi‑disciplinary Lead Discovery organization (biophysics, biochemistry, structural biology, and protein science) as well as the broader organization including biology, computational chemistry, and medicinal chemistry. Specific responsibilities require operation of mass spectrometry systems (Thermo Orbitrap, Agilent QTof), and associated sample prep/data interpretation. This role will focus on LC‑MS proteomics assay applications (quantitative targeted, off‑target) to identify and quantify proteins and associated modifications. Experience in additional MS platforms such as intact mass, HDX‑MS and small‑molecule quantitation is highly desirable. The ideal candidate will be responsible to execute on MS platforms and effectively communicate results to colleagues within Lead Discovery and project teams.
Responsibilities
Application and co‑development of various quantitative LC‑MS2 proteomics assays (DDA, DIA, PRM, TMT) to support ligand‑treated biological samples.
Proficient with sample preparation (TMT‑labeling and affinity enrichment) and MS data interpretation (Skyline, Proteome Discoverer, Sequest).
Highly capable of independently operating and maintaining LC‑MS systems (Thermo‑Ascend, Thermo‑Lumos).
Key contributor within Mass Spec Technologies team, supporting our capability to provide both routine and advanced MS qualitative and quantitative data to support multiple drug programs.
Collaborate with other members of the Lead Discovery team (protein sciences, biophysics, biochemistry, structural biology) to characterize protein targets through small molecule ligand binding assays.
Work with Treeline Lab Operations staff and external vendors to ensure smooth laboratory operations.
Qualifications
Ph.D. degree plus 4+ years focused mass spectrometry experience in a scientific or technical field, and demonstrated lab hands‑on experience.
At least 2 years of drug discovery experience in biotech or pharma.
Recruitment fraud statement
Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.
We do not conduct interviews through Skype or Telegram.
Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.
You can find more information about job scams at consumer.ftc.gov/articles/job-scams.
To report job scams, head to ReportFraud.ftc.gov.
Notice to Search Firms/Third‑Party Recruitment Agencies (Recruiters): The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.
Seniority level Mid‑Senior level
Employment type Full‑time
Job function Research, Analyst, and Information Technology
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Senior Scientist, Mass Spectrometry Technologies
role at
Treeline
Treeline Biosciences is an innovative biotechnology company, founded by an experienced team of biopharmaceutical scientists and executives, committed to developing new medicines against difficult to drug targets in cancer and other life‑threatening diseases. We are pursuing a uniquely integrated approach that applies modern and emerging tools in genomics, lead discovery, medicinal chemistry, and computation to reduce the time and risks of drug discovery.
About the Role We are seeking an experienced, enthusiastic, and highly motivated senior scientist to join our Mass Spectrometry Technologies group in San Diego, CA to deliver high-quality scientific data and drive small molecule drug discovery. The candidate will be part of a larger mass spectrometry team focused in part on applying and developing proteomics approaches to support early and later stage drug‑discovery. The successful candidate will be a critical collaborator within the multi‑disciplinary Lead Discovery organization (biophysics, biochemistry, structural biology, and protein science) as well as the broader organization including biology, computational chemistry, and medicinal chemistry. Specific responsibilities require operation of mass spectrometry systems (Thermo Orbitrap, Agilent QTof), and associated sample prep/data interpretation. This role will focus on LC‑MS proteomics assay applications (quantitative targeted, off‑target) to identify and quantify proteins and associated modifications. Experience in additional MS platforms such as intact mass, HDX‑MS and small‑molecule quantitation is highly desirable. The ideal candidate will be responsible to execute on MS platforms and effectively communicate results to colleagues within Lead Discovery and project teams.
Responsibilities
Application and co‑development of various quantitative LC‑MS2 proteomics assays (DDA, DIA, PRM, TMT) to support ligand‑treated biological samples.
Proficient with sample preparation (TMT‑labeling and affinity enrichment) and MS data interpretation (Skyline, Proteome Discoverer, Sequest).
Highly capable of independently operating and maintaining LC‑MS systems (Thermo‑Ascend, Thermo‑Lumos).
Key contributor within Mass Spec Technologies team, supporting our capability to provide both routine and advanced MS qualitative and quantitative data to support multiple drug programs.
Collaborate with other members of the Lead Discovery team (protein sciences, biophysics, biochemistry, structural biology) to characterize protein targets through small molecule ligand binding assays.
Work with Treeline Lab Operations staff and external vendors to ensure smooth laboratory operations.
Qualifications
Ph.D. degree plus 4+ years focused mass spectrometry experience in a scientific or technical field, and demonstrated lab hands‑on experience.
At least 2 years of drug discovery experience in biotech or pharma.
Recruitment fraud statement
Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.
We do not conduct interviews through Skype or Telegram.
Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.
You can find more information about job scams at consumer.ftc.gov/articles/job-scams.
To report job scams, head to ReportFraud.ftc.gov.
Notice to Search Firms/Third‑Party Recruitment Agencies (Recruiters): The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.
Seniority level Mid‑Senior level
Employment type Full‑time
Job function Research, Analyst, and Information Technology
Referrals increase your chances of interviewing at Treeline by 2x
Get notified about new Senior Scientist jobs in
San Diego, CA .
#J-18808-Ljbffr