CAMRIS
Overview
We are seeking a
Bioengineering Scientist
to support the National Institutes of Health’s (NIH), world renowned National Institute of Allergy and Infectious Diseases (NIAID) in Bethesda, MD. Our NIAID professional, technical, and scientific support personnel are part of a preeminent team focused on positively impacting millions of lives around the world with groundbreaking research. Candidates will work at a prominent and vibrant NIAID worksite to directly support exciting ongoing research activities as a contractor team member. Accelerate your career and apply below to help us make a difference.
CAMRIS International is a dynamic clinical research and international development firm that achieves innovative solutions to health and development challenges through high-quality, cost-effective programs and research management services. We combine our proven systems with today’s most effective, evidence-based best practices. Our core practice areas include: clinical research; vaccine research, microbiology and infectious disease research, development and production; biodefense; global health security; and HIV/AIDS programs.
Our employees enjoy a collegial environment where individual contributions matter at all levels. At CAMRIS, you will notably improve the lives of people at home and abroad.
Responsibilities
Develop microfluidics-based approaches for analysis of intra-host virus diversity and evolution, such as:
An approach for high-throughput, single-copy, full-length sequencing of purified virus genomes, to include the following:
Optimized virus inactivation and nucleic acid extraction procedures from blood and body fluids.
Customized microfluidic devices, regimes of operation, and reagents that partition extracted virus genomes in aqueous solution into monodisperse water-in-oil emulsions and thus enable downstream single-copy analysis.
An approach for high-throughput sequencing of individual intact virions, to include the following:
Non-destructive procedures for abrogating the infectivity of intact virions in suspension.
Customized microfluidic devices, regimes of operation, and reagents that can partition single-virion suspensions into water-in-oil emulsions at limiting dilution and thus enable downstream single-virion analysis.
Maintain records of all work using appropriate electronic systems.
Present results at internal and external meetings.
Collaborate with NIH and non-NIH scientists.
Train other NIH scientists in methods under development.
Contribute to original research manuscripts describing findings.
Additional duties as assigned.
Qualifications
Ph.D. in bioengineering, mechanical engineering, or physics and 2+ years of experience.
Professional competency with design and fabrication of microfluidic devices, including flow based droplet generators, using soft lithography (i.e., template design/production and device generation in polydimethylsiloxane [PDMS]) and glass fabrication techniques.
Professional competency with operation of the Pacific Biosciences Revio single-molecule real time (SMRT) sequencer platform.
Professional competency with basic bioinformatic and evolutionary biology tools for sequence analysis, including current softwares for database searches, multiple sequence alignment generation, and phylogenetic inference.
Professional competency with RNA extraction from human blood and body fluid samples, reverse transcription, polymerase chain reaction, and sequencing library preparation and quality control.
Intensive experience with laboratory automation, including liquid handling systems.
Experience with the application of complex bioinformatic pipelines for next-generation sequence data analysis.
Working understanding of human immunology, with emphasis on innate and adaptive antiviral host responses.
Track record of high-profile, peer-reviewed, first-author publication in the field of bioengineering.
Track record of high-profile, peer-reviewed, first-author publication in the field of virus evolution.
Track record of high-impact publications related to RNA virus infections.
Physical Requirements The physical requirements described here are representative of those that must be met by a candidate to perform the essential functions of this job. Reasonable accommodations may be provided to enable individuals with disabilities to perform essential job functions.
Ability to lift or carry less than 25 pounds, lift or carry 25 – 50 pounds, push or pull less than 25 pounds, push or pull 25 – 45 pounds, reach above shoulder level and use both hands.
Ability to work alone and closely with others.
Will be required to be in contact with nonhuman primate tissues, human blood or other body fluids and class 1 lasers.
Will have contact with HIV-1 and SIV.
Will work with corrosive substances, inorganic dust and powders, plastics, petroleum products and solvents.
Must be able to wear personal protective equipment (PPE), including gloves, face shields/goggles, safety glasses, lab coat, and clean room uniform.
Please submit your resume online at www.CAMRIS.com. CAMRIS is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran status, disability status, or any other characteristic protected by any applicable federal, state, or local law.
CAMRIS offers a comprehensive benefits package, including medical, dental, and vision insurance for individuals and families, FSAs, HSA, life and AD&D insurance, short- and long-term disability, legal services, voluntary hospital indemnity, critical illness and accident insurances, EAP, pet insurance, 401(k) with employer match and Roth option, tuition and professional reimbursement, public transportation support in the DMV area, a referral bonus program, vacation with tenure-based increases, PTO, 11 paid holidays, paid bonding leave, and paid supplemental short-term disability.
Employment is contingent upon successful completion of a Public Trust-level background check, a requirement for this position under an active federal contract. The background check process may include, but is not limited to, the following: (1) contacting your professional references; (2) verification of previous employment, education and credentials; (3) a criminal background check; (4) use/abuse of federally-controlled substances; and (5) a department of motor vehicle check. Candidates must be prepared to fully complete any required background check questionnaire during initial onboarding.
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Bioengineering Scientist
to support the National Institutes of Health’s (NIH), world renowned National Institute of Allergy and Infectious Diseases (NIAID) in Bethesda, MD. Our NIAID professional, technical, and scientific support personnel are part of a preeminent team focused on positively impacting millions of lives around the world with groundbreaking research. Candidates will work at a prominent and vibrant NIAID worksite to directly support exciting ongoing research activities as a contractor team member. Accelerate your career and apply below to help us make a difference.
CAMRIS International is a dynamic clinical research and international development firm that achieves innovative solutions to health and development challenges through high-quality, cost-effective programs and research management services. We combine our proven systems with today’s most effective, evidence-based best practices. Our core practice areas include: clinical research; vaccine research, microbiology and infectious disease research, development and production; biodefense; global health security; and HIV/AIDS programs.
Our employees enjoy a collegial environment where individual contributions matter at all levels. At CAMRIS, you will notably improve the lives of people at home and abroad.
Responsibilities
Develop microfluidics-based approaches for analysis of intra-host virus diversity and evolution, such as:
An approach for high-throughput, single-copy, full-length sequencing of purified virus genomes, to include the following:
Optimized virus inactivation and nucleic acid extraction procedures from blood and body fluids.
Customized microfluidic devices, regimes of operation, and reagents that partition extracted virus genomes in aqueous solution into monodisperse water-in-oil emulsions and thus enable downstream single-copy analysis.
An approach for high-throughput sequencing of individual intact virions, to include the following:
Non-destructive procedures for abrogating the infectivity of intact virions in suspension.
Customized microfluidic devices, regimes of operation, and reagents that can partition single-virion suspensions into water-in-oil emulsions at limiting dilution and thus enable downstream single-virion analysis.
Maintain records of all work using appropriate electronic systems.
Present results at internal and external meetings.
Collaborate with NIH and non-NIH scientists.
Train other NIH scientists in methods under development.
Contribute to original research manuscripts describing findings.
Additional duties as assigned.
Qualifications
Ph.D. in bioengineering, mechanical engineering, or physics and 2+ years of experience.
Professional competency with design and fabrication of microfluidic devices, including flow based droplet generators, using soft lithography (i.e., template design/production and device generation in polydimethylsiloxane [PDMS]) and glass fabrication techniques.
Professional competency with operation of the Pacific Biosciences Revio single-molecule real time (SMRT) sequencer platform.
Professional competency with basic bioinformatic and evolutionary biology tools for sequence analysis, including current softwares for database searches, multiple sequence alignment generation, and phylogenetic inference.
Professional competency with RNA extraction from human blood and body fluid samples, reverse transcription, polymerase chain reaction, and sequencing library preparation and quality control.
Intensive experience with laboratory automation, including liquid handling systems.
Experience with the application of complex bioinformatic pipelines for next-generation sequence data analysis.
Working understanding of human immunology, with emphasis on innate and adaptive antiviral host responses.
Track record of high-profile, peer-reviewed, first-author publication in the field of bioengineering.
Track record of high-profile, peer-reviewed, first-author publication in the field of virus evolution.
Track record of high-impact publications related to RNA virus infections.
Physical Requirements The physical requirements described here are representative of those that must be met by a candidate to perform the essential functions of this job. Reasonable accommodations may be provided to enable individuals with disabilities to perform essential job functions.
Ability to lift or carry less than 25 pounds, lift or carry 25 – 50 pounds, push or pull less than 25 pounds, push or pull 25 – 45 pounds, reach above shoulder level and use both hands.
Ability to work alone and closely with others.
Will be required to be in contact with nonhuman primate tissues, human blood or other body fluids and class 1 lasers.
Will have contact with HIV-1 and SIV.
Will work with corrosive substances, inorganic dust and powders, plastics, petroleum products and solvents.
Must be able to wear personal protective equipment (PPE), including gloves, face shields/goggles, safety glasses, lab coat, and clean room uniform.
Please submit your resume online at www.CAMRIS.com. CAMRIS is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran status, disability status, or any other characteristic protected by any applicable federal, state, or local law.
CAMRIS offers a comprehensive benefits package, including medical, dental, and vision insurance for individuals and families, FSAs, HSA, life and AD&D insurance, short- and long-term disability, legal services, voluntary hospital indemnity, critical illness and accident insurances, EAP, pet insurance, 401(k) with employer match and Roth option, tuition and professional reimbursement, public transportation support in the DMV area, a referral bonus program, vacation with tenure-based increases, PTO, 11 paid holidays, paid bonding leave, and paid supplemental short-term disability.
Employment is contingent upon successful completion of a Public Trust-level background check, a requirement for this position under an active federal contract. The background check process may include, but is not limited to, the following: (1) contacting your professional references; (2) verification of previous employment, education and credentials; (3) a criminal background check; (4) use/abuse of federally-controlled substances; and (5) a department of motor vehicle check. Candidates must be prepared to fully complete any required background check questionnaire during initial onboarding.
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