Amgen
Senior Principal Scientist – Target Discovery & Biology (TD&B)
Amgen, Thousand Oaks, California, United States, 91362
Senior Principal Scientist – Target Discovery & Biology (TD&B)
Join to apply for the
Senior Principal Scientist – Target Discovery & Biology (TD&B)
role at
Amgen
Amgen’s Mission of Serving Patients
At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission — to serve patients living with serious illnesses — drives all that we do.
Since 1980, we’ve helped pioneer biotechnology in our fight against the world’s toughest diseases. With a focus on Oncology, Inflammation, General Medicine, and Rare Disease, we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on patients’ lives by researching, manufacturing, and delivering innovative medicines.
Our award‑winning culture is collaborative, innovative, and science‑based. If you have a passion for challenges and the opportunities they bring, you’ll thrive at Amgen. Join us and transform patients’ lives while advancing your career.
What You Will Do Amgen’s Target Discovery & Biology (TD&B) organization integrates functional genomics, multi‑omics profiling, human genetics, and complex in‑vitro systems to uncover new biological insights and therapeutic targets. TD&B partners closely across Amgen’s therapeutic areas to translate data into discovery, accelerating the path to target development.
We are seeking a highly motivated, innovative, and experienced Senior Principal Scientist based in Thousand Oaks to lead a team focused on the development, delivery, and implementation of complex in‑vitro models that power target discovery and functional genomics efforts. In this essential role, you will be part of a dynamic, cross‑functional team advancing target and biological discovery.
Provide scientific and operational leadership for a team of scientists delivering advanced in‑vitro models and screening‑ready systems in collaboration with therapeutic area partners.
Guide the design, optimization, and screen implementation of cellular models that capture disease‑relevant biology, integrating insights from disease tissue profiling data.
Champion partnerships with automation colleagues to accelerate model deployment and reproducibility.
Collaborate with Amgen therapeutic area scientists to define requirements, ensure biological relevance, and deliver systems that enable mechanistic and translational insights.
Identify and implement emerging technologies in cell engineering, automation, and complex model systems to enhance the sophistication and throughput of discovery platforms.
Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline.
What We Expect Of You The dynamic professional we seek is a leader with the following qualifications.
Basic Qualifications
Doctorate (PhD, PharmD, or MD) with relevant post‑doc where applicable and 3 years of directly related experience
Or Master’s degree and 6 years of directly related experience
Or Bachelor’s degree and 8 years of directly related experience
Preferred Qualifications
Doctorate degree in cell biology, molecular biology, biomedical engineering, or related discipline.
6+ years of relevant experience in biotech or pharma, including leadership of scientific teams.
Strong track record in complex in‑vitro model development, cell engineering, and high‑throughput or automated screening.
Experience with high‑content imaging and transcriptional assay readouts.
Demonstrated ability to collaborate with cross‑functional teams to translate disease biology into experimental models.
Experience with viral vector systems (AAV, lentivirus, or related technologies) for gene delivery and perturbation.
Experience in leading or mentoring scientists, with proven success in project execution and team development.
Familiarity with data‑driven discovery approaches, including integration of genetic or multi‑omics insights.
Excellent organizational and communication skills, with the ability to drive cross‑site collaboration in a matrixed research environment.
What You Can Expect Of Us We support your professional and personal growth with competitive benefits and a collaborative culture.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, including:
Comprehensive employee benefits package with retirement and savings plan, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
Discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan.
Stock‑based long‑term incentives.
Award‑winning time‑off plans.
Flexible work models where possible.
Apply now and make a lasting impact with the Amgen team.
In any materials you submit, you may redact or remove age‑identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadline: Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number of applications or select a candidate.
Sponsorship for this role is not guaranteed.
As an organization dedicated to improving quality of life, Amgen fosters an inclusive environment built on diverse, ethical, and highly accomplished people who respect each other and live the Amgen values.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Seniority level Not Applicable
Employment type Full‑time
Job function Research
Industries Biotechnology Research and Pharmaceutical Manufacturing
Referrals increase your chances of interviewing at Amgen by 2x
Get notified about new Senior Principal Scientist jobs in
Thousand Oaks, CA .
Contact careers.amgen.com
#J-18808-Ljbffr
Senior Principal Scientist – Target Discovery & Biology (TD&B)
role at
Amgen
Amgen’s Mission of Serving Patients
At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission — to serve patients living with serious illnesses — drives all that we do.
Since 1980, we’ve helped pioneer biotechnology in our fight against the world’s toughest diseases. With a focus on Oncology, Inflammation, General Medicine, and Rare Disease, we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on patients’ lives by researching, manufacturing, and delivering innovative medicines.
Our award‑winning culture is collaborative, innovative, and science‑based. If you have a passion for challenges and the opportunities they bring, you’ll thrive at Amgen. Join us and transform patients’ lives while advancing your career.
What You Will Do Amgen’s Target Discovery & Biology (TD&B) organization integrates functional genomics, multi‑omics profiling, human genetics, and complex in‑vitro systems to uncover new biological insights and therapeutic targets. TD&B partners closely across Amgen’s therapeutic areas to translate data into discovery, accelerating the path to target development.
We are seeking a highly motivated, innovative, and experienced Senior Principal Scientist based in Thousand Oaks to lead a team focused on the development, delivery, and implementation of complex in‑vitro models that power target discovery and functional genomics efforts. In this essential role, you will be part of a dynamic, cross‑functional team advancing target and biological discovery.
Provide scientific and operational leadership for a team of scientists delivering advanced in‑vitro models and screening‑ready systems in collaboration with therapeutic area partners.
Guide the design, optimization, and screen implementation of cellular models that capture disease‑relevant biology, integrating insights from disease tissue profiling data.
Champion partnerships with automation colleagues to accelerate model deployment and reproducibility.
Collaborate with Amgen therapeutic area scientists to define requirements, ensure biological relevance, and deliver systems that enable mechanistic and translational insights.
Identify and implement emerging technologies in cell engineering, automation, and complex model systems to enhance the sophistication and throughput of discovery platforms.
Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline.
What We Expect Of You The dynamic professional we seek is a leader with the following qualifications.
Basic Qualifications
Doctorate (PhD, PharmD, or MD) with relevant post‑doc where applicable and 3 years of directly related experience
Or Master’s degree and 6 years of directly related experience
Or Bachelor’s degree and 8 years of directly related experience
Preferred Qualifications
Doctorate degree in cell biology, molecular biology, biomedical engineering, or related discipline.
6+ years of relevant experience in biotech or pharma, including leadership of scientific teams.
Strong track record in complex in‑vitro model development, cell engineering, and high‑throughput or automated screening.
Experience with high‑content imaging and transcriptional assay readouts.
Demonstrated ability to collaborate with cross‑functional teams to translate disease biology into experimental models.
Experience with viral vector systems (AAV, lentivirus, or related technologies) for gene delivery and perturbation.
Experience in leading or mentoring scientists, with proven success in project execution and team development.
Familiarity with data‑driven discovery approaches, including integration of genetic or multi‑omics insights.
Excellent organizational and communication skills, with the ability to drive cross‑site collaboration in a matrixed research environment.
What You Can Expect Of Us We support your professional and personal growth with competitive benefits and a collaborative culture.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, including:
Comprehensive employee benefits package with retirement and savings plan, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
Discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan.
Stock‑based long‑term incentives.
Award‑winning time‑off plans.
Flexible work models where possible.
Apply now and make a lasting impact with the Amgen team.
In any materials you submit, you may redact or remove age‑identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadline: Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number of applications or select a candidate.
Sponsorship for this role is not guaranteed.
As an organization dedicated to improving quality of life, Amgen fosters an inclusive environment built on diverse, ethical, and highly accomplished people who respect each other and live the Amgen values.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Seniority level Not Applicable
Employment type Full‑time
Job function Research
Industries Biotechnology Research and Pharmaceutical Manufacturing
Referrals increase your chances of interviewing at Amgen by 2x
Get notified about new Senior Principal Scientist jobs in
Thousand Oaks, CA .
Contact careers.amgen.com
#J-18808-Ljbffr