BioSpace
Senior Principal Scientist Target Discovery & Biology (TD&B)
BioSpace, Thousand Oaks, California, United States, 91362
Senior Principal Scientist Target Discovery & Biology (TD&B)
Join Amgen’s mission of serving patients. At Amgen, we are dedicated to helping patients living with serious illnesses. Since 1980, we have pioneered biotech in oncology, inflammation, general medicine, and rare disease, reaching millions of patients each year. As a member of our team, you will help research, manufacture, and deliver innovative medicines. What You Will Do
Our Target Discovery & Biology (TD&B) organization integrates functional genomics screening, multi-omics profiling, human genetics, and complex in‑vitro systems to uncover new biological insights and therapeutic targets. Provide scientific and operational leadership for a team of scientists delivering advanced in‑vitro models and screening‑ready systems in collaboration with therapeutic area partners. Guide the design, optimization, and screen implementation of cellular models that capture disease-relevant biology, integrating insights from disease tissue profiling data. Champion partnerships with automation colleagues to accelerate model deployment and reproducibility. Collaborate with Amgen therapeutic area scientists to define requirements, ensure biological relevance, and deliver systems that enable mechanistic and translational insights. Identify and implement emerging technologies in cell engineering, automation, and complex model systems to enhance the sophistication and throughput of discovery platforms. Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline. What We Expect of You
We seek a leader with the following qualifications. Basic Qualifications
Doctorate degree (PhD, PharmD, or MD) with relevant post‑doc (minimum 3 years of directly related experience) OR Master’s degree (minimum 6 years of directly related experience) OR Bachelor’s degree (minimum 8 years of directly related experience). Preferred Qualifications
Doctorate in cell biology, molecular biology, biomedical engineering, or related discipline. 6+ years of relevant experience in biotech or pharma, including leadership of scientific teams. Strong track record in complex in‑vitro model development, cell engineering, and high‑throughput or automated screening. Experience with high‑content imaging and transcriptional assay readouts. Demonstrated ability to collaborate with cross‑functional teams to translate disease biology into experimental models. Experience with viral vector systems (AAV, lentivirus or related technologies) for gene delivery and perturbation. Experience in leading or mentoring scientists with proven success in project execution and team development. Familiarity with data‑driven discovery approaches, including integration of genetic or multi‑omics insights. Excellent organizational and communication skills, with the ability to drive cross‑site collaboration in a matrixed research environment. What You Can Expect of Us
We support your professional and personal growth through competitive benefits and a collaborative culture. Benefits
A comprehensive employee benefits package, including retirement and savings plan, medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Discretionary annual bonus program or sales-based incentive plan for field sales. Stock‑based long‑term incentives. Award‑winning time‑off plans. Flexible work models where possible. Application deadline: Amgen does not have an application deadline for this position; we will continue accepting applications until we find a suitable candidate. Sponsorship for this role is not guaranteed. Amgen is an Equal Opportunity Employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodations.
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Join Amgen’s mission of serving patients. At Amgen, we are dedicated to helping patients living with serious illnesses. Since 1980, we have pioneered biotech in oncology, inflammation, general medicine, and rare disease, reaching millions of patients each year. As a member of our team, you will help research, manufacture, and deliver innovative medicines. What You Will Do
Our Target Discovery & Biology (TD&B) organization integrates functional genomics screening, multi-omics profiling, human genetics, and complex in‑vitro systems to uncover new biological insights and therapeutic targets. Provide scientific and operational leadership for a team of scientists delivering advanced in‑vitro models and screening‑ready systems in collaboration with therapeutic area partners. Guide the design, optimization, and screen implementation of cellular models that capture disease-relevant biology, integrating insights from disease tissue profiling data. Champion partnerships with automation colleagues to accelerate model deployment and reproducibility. Collaborate with Amgen therapeutic area scientists to define requirements, ensure biological relevance, and deliver systems that enable mechanistic and translational insights. Identify and implement emerging technologies in cell engineering, automation, and complex model systems to enhance the sophistication and throughput of discovery platforms. Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline. What We Expect of You
We seek a leader with the following qualifications. Basic Qualifications
Doctorate degree (PhD, PharmD, or MD) with relevant post‑doc (minimum 3 years of directly related experience) OR Master’s degree (minimum 6 years of directly related experience) OR Bachelor’s degree (minimum 8 years of directly related experience). Preferred Qualifications
Doctorate in cell biology, molecular biology, biomedical engineering, or related discipline. 6+ years of relevant experience in biotech or pharma, including leadership of scientific teams. Strong track record in complex in‑vitro model development, cell engineering, and high‑throughput or automated screening. Experience with high‑content imaging and transcriptional assay readouts. Demonstrated ability to collaborate with cross‑functional teams to translate disease biology into experimental models. Experience with viral vector systems (AAV, lentivirus or related technologies) for gene delivery and perturbation. Experience in leading or mentoring scientists with proven success in project execution and team development. Familiarity with data‑driven discovery approaches, including integration of genetic or multi‑omics insights. Excellent organizational and communication skills, with the ability to drive cross‑site collaboration in a matrixed research environment. What You Can Expect of Us
We support your professional and personal growth through competitive benefits and a collaborative culture. Benefits
A comprehensive employee benefits package, including retirement and savings plan, medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Discretionary annual bonus program or sales-based incentive plan for field sales. Stock‑based long‑term incentives. Award‑winning time‑off plans. Flexible work models where possible. Application deadline: Amgen does not have an application deadline for this position; we will continue accepting applications until we find a suitable candidate. Sponsorship for this role is not guaranteed. Amgen is an Equal Opportunity Employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodations.
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