Genepool Networks
Senior Director / VP, DMPK (Biotech | Boston, MA)
This range is provided by Genepool Networks. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.
A well‑funded, clinical‑stage biotechnology company is seeking a senior DMPK leader to build and lead Drug Metabolism and Pharmacokinetics strategy across discovery through IND and early clinical development. This highly visible role has broad cross‑functional exposure and meaningful influence on program direction and development decisions.
Location: Boston area.
Base pay range $240,000.00/yr - $340,000.00/yr
Key Responsibilities
Lead and own DMPK strategy from candidate selection through IND and early clinical development.
Serve as the DMPK subject matter expert on cross‑functional program teams, guiding decisions through interpretation of ADME and PK data.
Design, oversee, and interpret in vitro and in vivo ADME, transporter, and DMPK studies.
Identify and mitigate DDI and metabolism‑related risks and translate findings into clinical strategies.
Oversee bioanalytical approaches supporting TK/PK in GLP toxicology and first‑in‑human studies.
Contribute to human dose projection and translational PK strategies.
Author and review DMPK‑related sections of regulatory submissions and briefing materials.
Represent DMPK in regulatory interactions and scientific advice meetings as needed.
Select and manage CROs and consultants, ensuring scientific quality, timelines, and budget discipline.
Qualifications
Advanced degree (PhD, PharmD, or MS) in Pharmaceutical Sciences, Pharmacokinetics, Pharmacology, or a related discipline.
10+ years of DMPK experience supporting small‑molecule programs across discovery and development, including multiple INDs.
Strong expertise in ADME, PK, DDI risk assessment, and translational dose prediction.
Experience partnering cross‑functionally and communicating clearly with senior scientific and executive stakeholders.
Proven ability to manage external vendors and complex nonclinical workstreams.
Prior people management experience and interest in building and mentoring teams.
Experience supporting CNS or other challenging therapeutic areas is a plus.
Seniority level Director
Employment type Full‑time
Job function Science
Industries Biotechnology Research and Pharmaceutical Manufacturing
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A well‑funded, clinical‑stage biotechnology company is seeking a senior DMPK leader to build and lead Drug Metabolism and Pharmacokinetics strategy across discovery through IND and early clinical development. This highly visible role has broad cross‑functional exposure and meaningful influence on program direction and development decisions.
Location: Boston area.
Base pay range $240,000.00/yr - $340,000.00/yr
Key Responsibilities
Lead and own DMPK strategy from candidate selection through IND and early clinical development.
Serve as the DMPK subject matter expert on cross‑functional program teams, guiding decisions through interpretation of ADME and PK data.
Design, oversee, and interpret in vitro and in vivo ADME, transporter, and DMPK studies.
Identify and mitigate DDI and metabolism‑related risks and translate findings into clinical strategies.
Oversee bioanalytical approaches supporting TK/PK in GLP toxicology and first‑in‑human studies.
Contribute to human dose projection and translational PK strategies.
Author and review DMPK‑related sections of regulatory submissions and briefing materials.
Represent DMPK in regulatory interactions and scientific advice meetings as needed.
Select and manage CROs and consultants, ensuring scientific quality, timelines, and budget discipline.
Qualifications
Advanced degree (PhD, PharmD, or MS) in Pharmaceutical Sciences, Pharmacokinetics, Pharmacology, or a related discipline.
10+ years of DMPK experience supporting small‑molecule programs across discovery and development, including multiple INDs.
Strong expertise in ADME, PK, DDI risk assessment, and translational dose prediction.
Experience partnering cross‑functionally and communicating clearly with senior scientific and executive stakeholders.
Proven ability to manage external vendors and complex nonclinical workstreams.
Prior people management experience and interest in building and mentoring teams.
Experience supporting CNS or other challenging therapeutic areas is a plus.
Seniority level Director
Employment type Full‑time
Job function Science
Industries Biotechnology Research and Pharmaceutical Manufacturing
#J-18808-Ljbffr