Neurocrine Biosciences
TEMP - Scientist, Mass Spectrometry
Neurocrine Biosciences, San Diego, California, United States, 92189
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TEMP - Scientist, Mass Spectrometry
role at
Neurocrine Biosciences
About The Role Our dynamic team is seeking a motivated, collaborative, and experienced TEMP scientist to support biologics characterization for discovery and lead optimization teams. The qualified individual will work closely with team members to design, develop, and execute assays to deliver robust and high‑quality data to drive decision‑making. The position requires excellent scientific, technical and laboratory skills, strong organizational and communications skills, and enthusiasm for contributing to a fast‑paced organization focused on discoveries of novel and differentiated therapeutic candidates.
Your Contributions (include, but are not limited to)
Develop and perform large molecule analytical and characterization assays under the supervision of senior scientists, including identity testing by intact mass and/or subunit analysis, glycan profiling, primary structure and PTM analysis by peptide mapping
Perform data analysis, interpret results, draft reports and document experiments in ELN, support stakeholders including discovery biology, protein engineering and lead optimization
Perform routine maintenance of HPLC and MS systems, prepare mobile phases, execute calibration and cleaning procedures, coordinate regular preventative maintenance troubleshooting under the supervision of team leaders
Execute sample preparation workflows, such as buffer exchange, immunoprecipitation, reduction and alkylation, enzymatic digestion
Manage sample receiving, testing and storage, maintain and track consumables including columns, buffer solutions, enzymes and chemicals
Track and document assay performance
Provide recommendations to improve process efficiency and research quality
Other duties as assigned
Requirements
BS/BA degree in scientific field and 2+ years of analytical chemistry experience; OR
MS/MA degree in scientific field and some relevant industry experience OR
PhD in related field
Experience in protein analytical method development for identification and quantitation is required, including physicochemical and MS-based methods
Good knowledge and demonstrated ability working with large molecule separation methods including reversed-phase HPLC, analytical SEC and CE-SDS
Solid understanding of mass spectrometry operating principles, including ionization, ion transfer, gas-phase fragmentation, and mass analyzers
Experience on high-resolution TOF and/or orbitrap mass analyzers is a plus
Working knowledge of protein chemistry, amino acid composition, primary structure, post-translational modifications, higher-order structure and protein-protein interactions is a plus
Collaborative and highly motivated
Ability to work as part of a team
Strong computer skills and experience with Prism, Excel, Word, etc.
Good communications, problem-solving, analytical thinking skills
Detail oriented
Ability to meet deadlines
Good project management skills
Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up exactly to what we have outlined in the job description.
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TEMP - Scientist, Mass Spectrometry
role at
Neurocrine Biosciences
About The Role Our dynamic team is seeking a motivated, collaborative, and experienced TEMP scientist to support biologics characterization for discovery and lead optimization teams. The qualified individual will work closely with team members to design, develop, and execute assays to deliver robust and high‑quality data to drive decision‑making. The position requires excellent scientific, technical and laboratory skills, strong organizational and communications skills, and enthusiasm for contributing to a fast‑paced organization focused on discoveries of novel and differentiated therapeutic candidates.
Your Contributions (include, but are not limited to)
Develop and perform large molecule analytical and characterization assays under the supervision of senior scientists, including identity testing by intact mass and/or subunit analysis, glycan profiling, primary structure and PTM analysis by peptide mapping
Perform data analysis, interpret results, draft reports and document experiments in ELN, support stakeholders including discovery biology, protein engineering and lead optimization
Perform routine maintenance of HPLC and MS systems, prepare mobile phases, execute calibration and cleaning procedures, coordinate regular preventative maintenance troubleshooting under the supervision of team leaders
Execute sample preparation workflows, such as buffer exchange, immunoprecipitation, reduction and alkylation, enzymatic digestion
Manage sample receiving, testing and storage, maintain and track consumables including columns, buffer solutions, enzymes and chemicals
Track and document assay performance
Provide recommendations to improve process efficiency and research quality
Other duties as assigned
Requirements
BS/BA degree in scientific field and 2+ years of analytical chemistry experience; OR
MS/MA degree in scientific field and some relevant industry experience OR
PhD in related field
Experience in protein analytical method development for identification and quantitation is required, including physicochemical and MS-based methods
Good knowledge and demonstrated ability working with large molecule separation methods including reversed-phase HPLC, analytical SEC and CE-SDS
Solid understanding of mass spectrometry operating principles, including ionization, ion transfer, gas-phase fragmentation, and mass analyzers
Experience on high-resolution TOF and/or orbitrap mass analyzers is a plus
Working knowledge of protein chemistry, amino acid composition, primary structure, post-translational modifications, higher-order structure and protein-protein interactions is a plus
Collaborative and highly motivated
Ability to work as part of a team
Strong computer skills and experience with Prism, Excel, Word, etc.
Good communications, problem-solving, analytical thinking skills
Detail oriented
Ability to meet deadlines
Good project management skills
Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up exactly to what we have outlined in the job description.
#J-18808-Ljbffr