Olema Oncology
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Senior Director, Business Applications
role at
Olema Oncology
Olema Oncology is dedicated to developing better medicines for breast cancer and beyond. Our lead program, palazestrant (OP-1250), is a complete estrogen receptor antagonist (CERAN) currently in development for metastatic breast cancer with blockbuster potential as a monotherapy and in combination in ER+/HER2- metastatic breast cancer. Our follow‑on product candidate, OP-3136, is a potent KAT6 inhibitor with best‑in‑class potential. Our scientific breakthroughs are accelerated through the ways in which we fearlessly support, motivate, and challenge one another. At Olema, we know that when we put people first, our work becomes second to none. If you’re ready to join us at the edge of something unstoppable, let’s make a profound impact together for our patients, for your career, for what’s beyond.
About the Role As the Senior Director of Business Applications reporting to the Vice President, Information Technology, you are a seasoned and visionary leader who will oversee and optimize all General & Administrative (G&A) business systems. You will lead a high‑impact team in enhancing, hardening, and scaling enterprise systems to support Olema’s transition toward commercialization and sustained growth. This is a unique opportunity to make a meaningful impact at a dynamic biotech company during a pivotal phase in its development.
This role is based in either our San Francisco or Boston office and will require 10% travel.
Responsibilities
Own the strategic roadmap, budget, and day‑to‑day management of G&A business systems including NetSuite, Prendio, Agiloft, BambooHR, Greenhouse, and Culture Amp
Harden existing systems to prepare for commercialization and ensure enterprise scalability, audit readiness, and compliance with SOX (404A & 404B) requirements
Partner with Finance, HR, Legal, Procurement, Talent, Facilities and IT teams to understand evolving business requirements and deliver efficient, scalable solutions
Ensure successful adoption of new technologies and enhancements through structured change management practices, including communication, training, and stakeholder alignment
Evaluate and implement AI‑driven tools and automation platforms, and workflow optimization solutions – such as Workato or similar iPaaS technologies – to improve business performance and operational efficiency
Drive continuous improvement and digital transformation efforts by identifying opportunities for process redesign, automation and integration across systems
Ensure application governance, data integrity, system security, and adherence to internal controls and SOX processes
Lead system and vendor evaluations, platform assessments, and RFP processes to achieve the optimal technical fit and value for the organization
Manage vendor relationships and contract negotiations for SaaS platforms and service providers
Provide oversight and partnership with R&D teams (~10–15% of your time) to support scientific applications, data workflows, and system integrations that enable research innovation
Mentor and grow a high‑performing Business Applications team aligned with Olema’s culture and mission
Ideal Candidate Profile Knowledge:
Bachelor’s degree in information systems, computer science, or related discipline; advanced degree preferred
Strong knowledge of AI technologies, data management, and automation tools to drive digital transformation
Demonstrated leadership in managing cross‑functional teams and complex system implementations
Proven success scaling and hardening systems in preparation for commercialization
Demonstrated ability to translate business requirements into technical solutions and architect scalable, future‑ready systems
Experience:
Minimum of 10+ years of experience managing enterprise applications, with a strong background in G&A systems within the biotech or pharmaceutical industry
Minimum of 5+ years of experience building, leading, managing, developing and mentoring direct reports
Hands‑on experience with NetSuite is a must. Prendio, Agiloft, BambooHR, Greenhouse, Culture Amp, Workato or similar tools highly preferred
Track record of process optimization, workflow automation, and driving operational efficiency
Experience working within or preparing organizations for SOX compliance, including system controls, audit requirements, and governance
Proven success in system and vendor selection, including leading evaluations, RFPs, and contract negotiations
Attributes:
Exceptional communication skills and the ability to influence stakeholders at all levels of the organization
Strong commitment to excellence and delivering outstanding user experiences
Highly analytical and data‑driven decision‑maker
Proactive, self‑motivated, and results‑oriented with a “bias for action”
Collaborative team player who thrives in a cross‑functional environment
Flexible and adaptable to evolving business needs and technology trends
Compensation The base pay range for this position is expected to be
$270,000 - $290,000
annually; however, the base pay offered may vary depending on location, market, job‑related knowledge, skills and capabilities, and experience. The total compensation package for this position also includes equity, bonus, and benefits.
Important Information We provide equal opportunity to all employees and applicants for employment and believe that great ideas and discoveries come from a mix of expertise, background, and experience. Olema is building a culture where the value of difference is celebrated.
We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long‑term careers. A summary of benefits is available for all applicants.
Please note: Olema doesn’t accept agency resumes and is not responsible for any fees related to unsolicited resumes.
Fraud Alert: We are aware of employment scams where individuals pose as representatives of Olema Oncology and make false use of our company name to defraud job seekers. To protect yourself, please note that Olema’s official email addresses end in @olema.com. Our official corporate website is olem.com; our careers page is olem.com/careers; our LinkedIn page is linkedin.com/company/olema-oncology. Please visit these links for official information from Olema. Communication from any other variant is fraudulent. Olema does not conduct interviews via text message/messaging platforms, will not ask you to download anything as part of your interview, will never request any form of payment, provide upfront payments of any kind, and does not make job offers without an in‑person interview.
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Senior Director, Business Applications
role at
Olema Oncology
Olema Oncology is dedicated to developing better medicines for breast cancer and beyond. Our lead program, palazestrant (OP-1250), is a complete estrogen receptor antagonist (CERAN) currently in development for metastatic breast cancer with blockbuster potential as a monotherapy and in combination in ER+/HER2- metastatic breast cancer. Our follow‑on product candidate, OP-3136, is a potent KAT6 inhibitor with best‑in‑class potential. Our scientific breakthroughs are accelerated through the ways in which we fearlessly support, motivate, and challenge one another. At Olema, we know that when we put people first, our work becomes second to none. If you’re ready to join us at the edge of something unstoppable, let’s make a profound impact together for our patients, for your career, for what’s beyond.
About the Role As the Senior Director of Business Applications reporting to the Vice President, Information Technology, you are a seasoned and visionary leader who will oversee and optimize all General & Administrative (G&A) business systems. You will lead a high‑impact team in enhancing, hardening, and scaling enterprise systems to support Olema’s transition toward commercialization and sustained growth. This is a unique opportunity to make a meaningful impact at a dynamic biotech company during a pivotal phase in its development.
This role is based in either our San Francisco or Boston office and will require 10% travel.
Responsibilities
Own the strategic roadmap, budget, and day‑to‑day management of G&A business systems including NetSuite, Prendio, Agiloft, BambooHR, Greenhouse, and Culture Amp
Harden existing systems to prepare for commercialization and ensure enterprise scalability, audit readiness, and compliance with SOX (404A & 404B) requirements
Partner with Finance, HR, Legal, Procurement, Talent, Facilities and IT teams to understand evolving business requirements and deliver efficient, scalable solutions
Ensure successful adoption of new technologies and enhancements through structured change management practices, including communication, training, and stakeholder alignment
Evaluate and implement AI‑driven tools and automation platforms, and workflow optimization solutions – such as Workato or similar iPaaS technologies – to improve business performance and operational efficiency
Drive continuous improvement and digital transformation efforts by identifying opportunities for process redesign, automation and integration across systems
Ensure application governance, data integrity, system security, and adherence to internal controls and SOX processes
Lead system and vendor evaluations, platform assessments, and RFP processes to achieve the optimal technical fit and value for the organization
Manage vendor relationships and contract negotiations for SaaS platforms and service providers
Provide oversight and partnership with R&D teams (~10–15% of your time) to support scientific applications, data workflows, and system integrations that enable research innovation
Mentor and grow a high‑performing Business Applications team aligned with Olema’s culture and mission
Ideal Candidate Profile Knowledge:
Bachelor’s degree in information systems, computer science, or related discipline; advanced degree preferred
Strong knowledge of AI technologies, data management, and automation tools to drive digital transformation
Demonstrated leadership in managing cross‑functional teams and complex system implementations
Proven success scaling and hardening systems in preparation for commercialization
Demonstrated ability to translate business requirements into technical solutions and architect scalable, future‑ready systems
Experience:
Minimum of 10+ years of experience managing enterprise applications, with a strong background in G&A systems within the biotech or pharmaceutical industry
Minimum of 5+ years of experience building, leading, managing, developing and mentoring direct reports
Hands‑on experience with NetSuite is a must. Prendio, Agiloft, BambooHR, Greenhouse, Culture Amp, Workato or similar tools highly preferred
Track record of process optimization, workflow automation, and driving operational efficiency
Experience working within or preparing organizations for SOX compliance, including system controls, audit requirements, and governance
Proven success in system and vendor selection, including leading evaluations, RFPs, and contract negotiations
Attributes:
Exceptional communication skills and the ability to influence stakeholders at all levels of the organization
Strong commitment to excellence and delivering outstanding user experiences
Highly analytical and data‑driven decision‑maker
Proactive, self‑motivated, and results‑oriented with a “bias for action”
Collaborative team player who thrives in a cross‑functional environment
Flexible and adaptable to evolving business needs and technology trends
Compensation The base pay range for this position is expected to be
$270,000 - $290,000
annually; however, the base pay offered may vary depending on location, market, job‑related knowledge, skills and capabilities, and experience. The total compensation package for this position also includes equity, bonus, and benefits.
Important Information We provide equal opportunity to all employees and applicants for employment and believe that great ideas and discoveries come from a mix of expertise, background, and experience. Olema is building a culture where the value of difference is celebrated.
We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long‑term careers. A summary of benefits is available for all applicants.
Please note: Olema doesn’t accept agency resumes and is not responsible for any fees related to unsolicited resumes.
Fraud Alert: We are aware of employment scams where individuals pose as representatives of Olema Oncology and make false use of our company name to defraud job seekers. To protect yourself, please note that Olema’s official email addresses end in @olema.com. Our official corporate website is olem.com; our careers page is olem.com/careers; our LinkedIn page is linkedin.com/company/olema-oncology. Please visit these links for official information from Olema. Communication from any other variant is fraudulent. Olema does not conduct interviews via text message/messaging platforms, will not ask you to download anything as part of your interview, will never request any form of payment, provide upfront payments of any kind, and does not make job offers without an in‑person interview.
#J-18808-Ljbffr