Axle
Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision‑making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).
Paid Time Off (Including Holidays)
Employee Referral Bonus
401K Match
Tuition reimbursement and professional development opportunities
Flexible Spending Accounts:
Healthcare (FSA)
Parking Reimbursement Account (PRK)
Dependent Care Assistant Program (DCAP)
Transportation Reimbursement Account (TRN)
Overview Axle is looking to add a driven, flexible, organized, and meticulous Bioengineering Scientist to our dynamic team. The Contractor(s) shall provide services in support of the overall functions of the Virus Persistence and Dynamic Section (VPDS), Vaccine Research Center (VRC).
Technical Requirements
Develop microfluidics-based approaches for analysis of intra-host virus diversity and evolution, such as:
An approach for high-throughput, single-copy, full-length sequencing of purified virus genomes, to include the following:
Optimized virus inactivation and nucleic acid extraction procedures from blood and body fluids
Customized microfluidic devices, regimes of operation, and reagents that partition extracted virus genomes in aqueous solution into monodisperse water-in-oil emulsions and thus enable downstream single-copy analysis:
An approach for high-throughput sequencing of individual intact virions, to include the following:
Non-destructive procedures for abrogating the infectivity of intact virions in suspension
Customized microfluidic devices, regimes of operation, and reagents that can partition single-virion suspensions into water-in-oil emulsions at limiting dilution and thus enable downstream single-virion analysis
Maintain records of all work using appropriate electronic systems
Present results at internal and external meetings
Collaborate with NIH and non-NIH scientists
Train other NIH scientists in methods under development
Contribute to original research manuscripts describing findings
Specific Qualifications
Ph.D. in bioengineering, mechanical engineering, or physics and 2+ years of experience.
Professional competency with design and fabrication of microfluidic devices, including flow-based droplet generators, using soft lithography (i.e., template design/production and device generation in polydimethylsiloxane [PDMS]) and glass fabrication techniques
Professional competency with operation of the Pacific Biosciences Revio single-molecule real-time (SMRT) sequencer platform
Professional competency with basic bioinformatic and evolutionary biology tools for sequence analysis, including current softwares for database searches, multiple sequence alignment generation, and phylogenetic inference
Professional competency with RNA extraction from human blood and body fluid samples, reverse transcription, polymerase chain reaction, and sequencing library preparation and quality control
Intensive experience with laboratory automation, including liquid handling systems
Experience with the application of complex bioinformatic pipelines for next-generation sequence data analysis
Working understanding of human immunology, with emphasis on innate and adaptive antiviral host responses
Track record of high-profile, peer-reviewed, first-author publication in the field of bioengineering
Track record of high-profile, peer-reviewed, first-author publication in the field of virus evolution
Track record of high-impact publications related to RNA virus infections
The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.
Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com
Disclaimer:
The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
Salary Range $120,000 - $140,000 USD
Voluntary Self-Identification For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.
Voluntary Self-Identification of Disability Form CC-305 Page 1 of 1 OMB Control Number 1250-0005 Expires 04/30/2026
Why are you being asked to complete this form?
We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.
How do you know if you have a disability?
A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability.
Disabilities include, but are not limited to:
Alcohol or other substance use disorder (not currently using drugs illegally)
Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
Blind or low vision
Cancer (past or present)
Cardiovascular or heart disease
Celiac disease
Cerebral palsy
Deaf or serious difficulty hearing
Diabetes
Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
Epilepsy or other seizure disorder
Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
Intellectual or developmental disability
Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
Missing limbs or partially missing limbs
Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
Partial or complete paralysis (any cause)
Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
Short stature (dwarfism)
Traumatic brain injury
Disability Status Select…
PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.
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Paid Time Off (Including Holidays)
Employee Referral Bonus
401K Match
Tuition reimbursement and professional development opportunities
Flexible Spending Accounts:
Healthcare (FSA)
Parking Reimbursement Account (PRK)
Dependent Care Assistant Program (DCAP)
Transportation Reimbursement Account (TRN)
Overview Axle is looking to add a driven, flexible, organized, and meticulous Bioengineering Scientist to our dynamic team. The Contractor(s) shall provide services in support of the overall functions of the Virus Persistence and Dynamic Section (VPDS), Vaccine Research Center (VRC).
Technical Requirements
Develop microfluidics-based approaches for analysis of intra-host virus diversity and evolution, such as:
An approach for high-throughput, single-copy, full-length sequencing of purified virus genomes, to include the following:
Optimized virus inactivation and nucleic acid extraction procedures from blood and body fluids
Customized microfluidic devices, regimes of operation, and reagents that partition extracted virus genomes in aqueous solution into monodisperse water-in-oil emulsions and thus enable downstream single-copy analysis:
An approach for high-throughput sequencing of individual intact virions, to include the following:
Non-destructive procedures for abrogating the infectivity of intact virions in suspension
Customized microfluidic devices, regimes of operation, and reagents that can partition single-virion suspensions into water-in-oil emulsions at limiting dilution and thus enable downstream single-virion analysis
Maintain records of all work using appropriate electronic systems
Present results at internal and external meetings
Collaborate with NIH and non-NIH scientists
Train other NIH scientists in methods under development
Contribute to original research manuscripts describing findings
Specific Qualifications
Ph.D. in bioengineering, mechanical engineering, or physics and 2+ years of experience.
Professional competency with design and fabrication of microfluidic devices, including flow-based droplet generators, using soft lithography (i.e., template design/production and device generation in polydimethylsiloxane [PDMS]) and glass fabrication techniques
Professional competency with operation of the Pacific Biosciences Revio single-molecule real-time (SMRT) sequencer platform
Professional competency with basic bioinformatic and evolutionary biology tools for sequence analysis, including current softwares for database searches, multiple sequence alignment generation, and phylogenetic inference
Professional competency with RNA extraction from human blood and body fluid samples, reverse transcription, polymerase chain reaction, and sequencing library preparation and quality control
Intensive experience with laboratory automation, including liquid handling systems
Experience with the application of complex bioinformatic pipelines for next-generation sequence data analysis
Working understanding of human immunology, with emphasis on innate and adaptive antiviral host responses
Track record of high-profile, peer-reviewed, first-author publication in the field of bioengineering
Track record of high-profile, peer-reviewed, first-author publication in the field of virus evolution
Track record of high-impact publications related to RNA virus infections
The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.
Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com
Disclaimer:
The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
Salary Range $120,000 - $140,000 USD
Voluntary Self-Identification For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.
Voluntary Self-Identification of Disability Form CC-305 Page 1 of 1 OMB Control Number 1250-0005 Expires 04/30/2026
Why are you being asked to complete this form?
We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.
How do you know if you have a disability?
A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability.
Disabilities include, but are not limited to:
Alcohol or other substance use disorder (not currently using drugs illegally)
Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
Blind or low vision
Cancer (past or present)
Cardiovascular or heart disease
Celiac disease
Cerebral palsy
Deaf or serious difficulty hearing
Diabetes
Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
Epilepsy or other seizure disorder
Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
Intellectual or developmental disability
Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
Missing limbs or partially missing limbs
Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
Partial or complete paralysis (any cause)
Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
Short stature (dwarfism)
Traumatic brain injury
Disability Status Select…
PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.
#J-18808-Ljbffr