Baylor College of Medicine
Research Associate - Electrophysiology
Baylor College of Medicine, Houston, Texas, United States, 77246
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Research Associate – Electrophysiology
role at
Baylor College of Medicine .
Summary The St-Pierre lab develops and applies new tools for monitoring and interrogating brain activity with millisecond-timescale temporal resolution. We seek an energetic team member to lead our efforts to characterize and apply new light-responsive proteins in vitro and in vivo. The Research Associate will work on two types of tools: (1) genetically encoded voltage indicators (GEVIs), fluorescent biosensors that report voltage as changes in brightness, and (2) optogenetic silencers, light-gated channels that inhibit neuronal firing. Characterization of these tools requires simultaneous electrophysiological recordings and optical excitation/imaging. This position provides exciting opportunities to work with the latest optical technologies and develop new skills in two-photon voltage imaging, protein engineering, and synthetic biology.
Location: Houston, TX
Responsibilities
Culture mammalian cells
Prepare brain slices, dissociated neurons, or both
Conduct experiments that combine electrophysiology and either optogenetic activation or optical imaging (multi-photon fluorescence microscopy)
Maintain reagent and tool supply related to the experiments
Maintain an electrophysiological rig, and troubleshoot if needed
Analyze data using commercial software or customized data pipelines
Teach techniques, procedures, and experimental design to other members of the lab
Communicate research results in group meetings, national or international conferences
Perform other job-related duties as assigned
Minimum Qualifications
Master's degree in Basic Science or a related field. Experience in lieu of degree will not be accepted.
Three years of relevant experience typically as a Research Assistant, Research Technician or Postdoctoral Fellow/Associate.
Department Specific Criteria
Must have experience with performing electrophysiology in dissociated neurons, brain slices or both
Must have experience with dissecting rat cortical, hippocampal neurons, or both
Must have experience maintaining an electrophysiology rig
Preferred Qualifications
Doctoral degree
Ability to express transgenes in neurons of brain slices using viruses and/or in utero electroporation
Experience with imaging neural activity (e.g. voltage or calcium) in brain slices or in vivo, using 1P and/or 2P imaging
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
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Research Associate – Electrophysiology
role at
Baylor College of Medicine .
Summary The St-Pierre lab develops and applies new tools for monitoring and interrogating brain activity with millisecond-timescale temporal resolution. We seek an energetic team member to lead our efforts to characterize and apply new light-responsive proteins in vitro and in vivo. The Research Associate will work on two types of tools: (1) genetically encoded voltage indicators (GEVIs), fluorescent biosensors that report voltage as changes in brightness, and (2) optogenetic silencers, light-gated channels that inhibit neuronal firing. Characterization of these tools requires simultaneous electrophysiological recordings and optical excitation/imaging. This position provides exciting opportunities to work with the latest optical technologies and develop new skills in two-photon voltage imaging, protein engineering, and synthetic biology.
Location: Houston, TX
Responsibilities
Culture mammalian cells
Prepare brain slices, dissociated neurons, or both
Conduct experiments that combine electrophysiology and either optogenetic activation or optical imaging (multi-photon fluorescence microscopy)
Maintain reagent and tool supply related to the experiments
Maintain an electrophysiological rig, and troubleshoot if needed
Analyze data using commercial software or customized data pipelines
Teach techniques, procedures, and experimental design to other members of the lab
Communicate research results in group meetings, national or international conferences
Perform other job-related duties as assigned
Minimum Qualifications
Master's degree in Basic Science or a related field. Experience in lieu of degree will not be accepted.
Three years of relevant experience typically as a Research Assistant, Research Technician or Postdoctoral Fellow/Associate.
Department Specific Criteria
Must have experience with performing electrophysiology in dissociated neurons, brain slices or both
Must have experience with dissecting rat cortical, hippocampal neurons, or both
Must have experience maintaining an electrophysiology rig
Preferred Qualifications
Doctoral degree
Ability to express transgenes in neurons of brain slices using viruses and/or in utero electroporation
Experience with imaging neural activity (e.g. voltage or calcium) in brain slices or in vivo, using 1P and/or 2P imaging
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
#J-18808-Ljbffr