BioSpace
Chemist/Senior Chemist ADC Drug-Linker Synthetic Process Development
BioSpace, Indianapolis, Indiana, us, 46262
Analytical Chemist – Antibody‑Drug Conjugates
2 days ago Be among the first 25 applicants
Company Overview At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring life‑changing medicines, improve disease understanding and management, and give back to communities through philanthropy and volunteerism. We put people first and seek individuals who are determined to make a difference worldwide.
Organization Overview The position focuses on small‑molecule drug‑linker synthetic chemistry within the Bioproduct Research and Development (BR&D) organization. BR&D develops and commercializes biologic therapeutics such as monoclonal antibodies and bioconjugates. We are building capabilities at the small‑molecule–biologics interface to support the growing pipeline of Antibody‑Drug Conjugates (ADCs).
Position Summary Our team is tasked with growing the chemistry infrastructure to synthesize and develop highly potent or cytotoxic ADC drug‑linkers. You will work in‑house and with external partners to develop and transfer processes for manufacturing.
Responsibilities
Synthesize complex payloads and drug‑linkers for preclinical toxicity studies and produce technical reports.
Collaborate with Lilly Discovery chemistry teams to understand and validate synthesis scale‑up requirements.
Support early‑phase Discovery and Toxicology groups by supplying synthetic material for new and emerging assets.
Problem‑solve in the laboratory to overcome synthetic challenges and improve workflows.
Maintain laboratory equipment and manage inventory and consumables.
Serve as the key point of contact for troubleshooting and develop chemistry solutions in real time.
Execute experiments to support process development, characterization, and range‑finding studies.
Generate data for regulatory filings.
Author technical reports and CMC‑related documents.
Basic Requirements
Bachelor’s and/or Master’s degree in Organic Chemistry, Chemistry, Biochemistry, or a related field.
0–2 years of experience in a synthetic organic chemistry laboratory environment.
Additional Preferences
Experience in a high‑potent laboratory handling potent or cytotoxic compounds.
Experience with Antibody‑Drug Conjugates (ADCs).
Scientific curiosity and interest in complementary disciplines within the pharmaceutical industry.
Familiarity with preparative scale chromatographic purification and lyophilization of small molecules.
Additional Information Potential exposure to chemicals, allergens, and loud noises.
Physical Demands / Travel
Physical demands consistent with a laboratory environment.
Travel up to 20%.
Work Environment This position’s work environment is a laboratory environment.
Accommodation We accommodate individuals with disabilities. If you need accommodation during the application process, please complete the accommodation request form.
EEO Statement Lilly is a proud EEO employer and does not discriminate on the basis of any legally protected status, including age, race, color, religion, gender identity, sex, sexual orientation, genetic information, ancestry, national origin, veteran status, or disability. Lilly’s employee resource groups include Africa, Middle East, Central Asia Network; Black Employees at Lilly; Chinese Culture Network; Japanese International Leadership Network (JILN); Lilly India Network; Organization of Latinx at Lilly (OLA); PRIDE (LGBTQ+ Allies); Veterans Leadership Network (VLN); Women’s Initiative for Leading at Lilly (WILL); and enAble for people with disabilities. Learn more about all of our groups.
Compensation and Benefits Actual compensation will depend on education, experience, skills, and location. Anticipated wage: $65,250 – $116,600. Full‑time employees are eligible for a company bonus and a comprehensive benefit program, including 401(k), pension, vacation, medical, dental, vision, prescription drug benefits, flexible benefits, life and death insurance, time‑off, leave of absence, and well‑being benefits.
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Company Overview At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring life‑changing medicines, improve disease understanding and management, and give back to communities through philanthropy and volunteerism. We put people first and seek individuals who are determined to make a difference worldwide.
Organization Overview The position focuses on small‑molecule drug‑linker synthetic chemistry within the Bioproduct Research and Development (BR&D) organization. BR&D develops and commercializes biologic therapeutics such as monoclonal antibodies and bioconjugates. We are building capabilities at the small‑molecule–biologics interface to support the growing pipeline of Antibody‑Drug Conjugates (ADCs).
Position Summary Our team is tasked with growing the chemistry infrastructure to synthesize and develop highly potent or cytotoxic ADC drug‑linkers. You will work in‑house and with external partners to develop and transfer processes for manufacturing.
Responsibilities
Synthesize complex payloads and drug‑linkers for preclinical toxicity studies and produce technical reports.
Collaborate with Lilly Discovery chemistry teams to understand and validate synthesis scale‑up requirements.
Support early‑phase Discovery and Toxicology groups by supplying synthetic material for new and emerging assets.
Problem‑solve in the laboratory to overcome synthetic challenges and improve workflows.
Maintain laboratory equipment and manage inventory and consumables.
Serve as the key point of contact for troubleshooting and develop chemistry solutions in real time.
Execute experiments to support process development, characterization, and range‑finding studies.
Generate data for regulatory filings.
Author technical reports and CMC‑related documents.
Basic Requirements
Bachelor’s and/or Master’s degree in Organic Chemistry, Chemistry, Biochemistry, or a related field.
0–2 years of experience in a synthetic organic chemistry laboratory environment.
Additional Preferences
Experience in a high‑potent laboratory handling potent or cytotoxic compounds.
Experience with Antibody‑Drug Conjugates (ADCs).
Scientific curiosity and interest in complementary disciplines within the pharmaceutical industry.
Familiarity with preparative scale chromatographic purification and lyophilization of small molecules.
Additional Information Potential exposure to chemicals, allergens, and loud noises.
Physical Demands / Travel
Physical demands consistent with a laboratory environment.
Travel up to 20%.
Work Environment This position’s work environment is a laboratory environment.
Accommodation We accommodate individuals with disabilities. If you need accommodation during the application process, please complete the accommodation request form.
EEO Statement Lilly is a proud EEO employer and does not discriminate on the basis of any legally protected status, including age, race, color, religion, gender identity, sex, sexual orientation, genetic information, ancestry, national origin, veteran status, or disability. Lilly’s employee resource groups include Africa, Middle East, Central Asia Network; Black Employees at Lilly; Chinese Culture Network; Japanese International Leadership Network (JILN); Lilly India Network; Organization of Latinx at Lilly (OLA); PRIDE (LGBTQ+ Allies); Veterans Leadership Network (VLN); Women’s Initiative for Leading at Lilly (WILL); and enAble for people with disabilities. Learn more about all of our groups.
Compensation and Benefits Actual compensation will depend on education, experience, skills, and location. Anticipated wage: $65,250 – $116,600. Full‑time employees are eligible for a company bonus and a comprehensive benefit program, including 401(k), pension, vacation, medical, dental, vision, prescription drug benefits, flexible benefits, life and death insurance, time‑off, leave of absence, and well‑being benefits.
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