GlaxoSmithKline
Postdoctoral Researcher, Quantitative Systems Pharmacology - Fixed Term Contract
GlaxoSmithKline, Waltham, Massachusetts, United States, 02254
Site Name: UK - Hertfordshire - Stevenage, USA - Massachusetts - Waltham
Posted Date: Jan 2 2026
430594 Postdoctoral Researcher, Quantitative Systems Pharmacology - 2 year Fixed Term Contract (FTC) The Clinical Pharmacology and Quantitative Medicine (CPQM) group in Respiratory, Immunology and Inflammation Research Unit, R&D GSK is recruiting for a Postdoctoral researcher in Quantitative Systems Pharmacology (QSP) to join their CPQM QSP team. The CPQM at GSK is a newly established organization with the remit to become a Centre of Excellence in Model-Informed Drug Development (MIDD). It uniquely integrates clinical pharmacology, digital medicine, translational imaging, and mechanistic & systems modelling.
This industrial QSP Postdoc position represents a unique opportunity for those with PhD, MD, PharmD or equivalent doctoral background, who have previous experience in mechanistic mathematical modelling to gain pharmaceutical industry experience of applying systems modelling and computational methodologies to drug discovery and development to advance the vision and mission of GSK’s rapidly expanding Respiratory, Inflammation and Immunology Disease portfolio.
We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.
In this role you will
Build mechanistic mathematical models of biological, physiological, and pathophysiological processes to evaluate disease, its pathways and progression as well as drug action to prevent, treat and cure diseases; and conduct simulations of virtual patients to inform target and/or asset prioritization and optimal trial design
Develop and/or utilize state-of-the-art mathematical tools including knowledge of non-linear dynamics, scientific ML and/or statistical techniques to gain insight into causal relationships between individual components of system-level and drug-level responses of drug-target-biomarker-disease-patient interaction
Identify relevant question(s) of interest by working with disease area experts across different disciplines and address the question(s) by applying mechanistic and systems modelling
Communicate and work in close collaboration with clinicians, biologists, clinical pharmacologists, pharmacometricians, statisticians, AIML, imaging, biomarker, genomics scientists and other cross-matrix colleagues to inform research and development programs and improve our understanding of disease mechanisms
Promote transparency and communicate R&D achievements through publications in appropriate scientific journals
Basic Qualifications & Skills We are looking for professionals with these required skills to achieve our goals:
PhD, MD, or PharmD with experience in mechanistic modelling and simulation and systems biology
Strong drive to quickly learn and build knowledge on a drug-disease system, the mechanism, endpoints, progression, prevention, treatments, and trial design
Strong communication skills and demonstrated ability to work in a multi-discipline team, using effective communication and taking personal accountability for timely delivery of results
Prior experience with applications in pharmaceutical research and development is a plus
Prior experience in Respiratory (e.g. COPD, IPF), Renal (e.g. CKD, nephrotoxicity), Hepatology (e.g. MASH) and/or Infections diseases (e.g. HBV) is a plus
Closing Date for Applications – 16th of January, 2026 (COB)
Salary ranges: If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $87,450 to $145,750. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits for employee and family, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at UKRecruitment.Adjustments@gsk.com where you can also request a call. Please note that if your enquiry does not relate to adjustments, we will not be able to support you through these channels.
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Posted Date: Jan 2 2026
430594 Postdoctoral Researcher, Quantitative Systems Pharmacology - 2 year Fixed Term Contract (FTC) The Clinical Pharmacology and Quantitative Medicine (CPQM) group in Respiratory, Immunology and Inflammation Research Unit, R&D GSK is recruiting for a Postdoctoral researcher in Quantitative Systems Pharmacology (QSP) to join their CPQM QSP team. The CPQM at GSK is a newly established organization with the remit to become a Centre of Excellence in Model-Informed Drug Development (MIDD). It uniquely integrates clinical pharmacology, digital medicine, translational imaging, and mechanistic & systems modelling.
This industrial QSP Postdoc position represents a unique opportunity for those with PhD, MD, PharmD or equivalent doctoral background, who have previous experience in mechanistic mathematical modelling to gain pharmaceutical industry experience of applying systems modelling and computational methodologies to drug discovery and development to advance the vision and mission of GSK’s rapidly expanding Respiratory, Inflammation and Immunology Disease portfolio.
We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.
In this role you will
Build mechanistic mathematical models of biological, physiological, and pathophysiological processes to evaluate disease, its pathways and progression as well as drug action to prevent, treat and cure diseases; and conduct simulations of virtual patients to inform target and/or asset prioritization and optimal trial design
Develop and/or utilize state-of-the-art mathematical tools including knowledge of non-linear dynamics, scientific ML and/or statistical techniques to gain insight into causal relationships between individual components of system-level and drug-level responses of drug-target-biomarker-disease-patient interaction
Identify relevant question(s) of interest by working with disease area experts across different disciplines and address the question(s) by applying mechanistic and systems modelling
Communicate and work in close collaboration with clinicians, biologists, clinical pharmacologists, pharmacometricians, statisticians, AIML, imaging, biomarker, genomics scientists and other cross-matrix colleagues to inform research and development programs and improve our understanding of disease mechanisms
Promote transparency and communicate R&D achievements through publications in appropriate scientific journals
Basic Qualifications & Skills We are looking for professionals with these required skills to achieve our goals:
PhD, MD, or PharmD with experience in mechanistic modelling and simulation and systems biology
Strong drive to quickly learn and build knowledge on a drug-disease system, the mechanism, endpoints, progression, prevention, treatments, and trial design
Strong communication skills and demonstrated ability to work in a multi-discipline team, using effective communication and taking personal accountability for timely delivery of results
Prior experience with applications in pharmaceutical research and development is a plus
Prior experience in Respiratory (e.g. COPD, IPF), Renal (e.g. CKD, nephrotoxicity), Hepatology (e.g. MASH) and/or Infections diseases (e.g. HBV) is a plus
Closing Date for Applications – 16th of January, 2026 (COB)
Salary ranges: If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $87,450 to $145,750. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits for employee and family, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at UKRecruitment.Adjustments@gsk.com where you can also request a call. Please note that if your enquiry does not relate to adjustments, we will not be able to support you through these channels.
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