Women In Bio
Postdoctoral Researcher, Quantitative Systems Pharmacology - Fixed Term Contract
Women In Bio, Waltham, Massachusetts, United States, 02254
430594 Postdoctoral Researcher, Quantitative Systems Pharmacology – 2 year Fixed Term Contract (FTC)
The Clinical Pharmacology and Quantitative Medicine (CPQM) group in Respiratory, Immunology and Inflammation Research Unit, R&D GSK is recruiting for a Postdoctoral researcher in Quantitative Systems Pharmacology (QSP) to join their CPQM QSP team. The CPQM at GSK is a newly established organisation with the remit to become a Centre of Excellence in Model‑Informed Drug Development (MIDD). It uniquely integrates clinical pharmacology, digital medicine, translational imaging, and mechanistic & systems modelling.
This industrial QSP Postdoc position represents a unique opportunity for those with PhD, MD, PharmD or equivalent doctoral background, who have previous experience in mechanistic mathematical modelling to gain pharmaceutical industry experience of applying systems modelling and computational methodologies to drug discovery and development to advance the vision and mission of GSK's rapidly expanding Respiratory, Inflammation and Immunology Disease portfolio.
In this role you will
Build mechanistic mathematical models of biological, physiological, and pathophysiological processes to evaluate disease, its pathways and progression as well as drug action to prevent, treat and cure diseases; and conduct simulations of virtual patients to inform target and/or asset prioritisation and optimal trial design.
Develop and/or utilise state‑of‑the‑art mathematical tools, including knowledge of non‑linear dynamics, scientific ML and/or statistical techniques to gain insight into causal relationships between individual components of system‑level and drug‑level responses of drug‑target‑biomarker‑disease‑patient interaction.
Identify relevant question(s) of interest by working with disease area experts across different disciplines and address the question(s) by applying mechanistic and systems modelling.
Communicate and work in close collaboration with clinicians, biologists, clinical pharmacologists, pharmacometricians, statisticians, AIML, imaging, biomarker, genomics scientists and other cross‑matrix colleagues to inform research and development programmes and improve our understanding of disease mechanisms.
Promote transparency and communicate R&D achievements through publications in appropriate scientific journals.
Basic Qualifications & Skills
PhD, MD, or PharmD with experience in mechanistic modelling and simulation and systems biology.
Strong drive to quickly learn and build knowledge on a drug‑disease system, the mechanism, endpoints, progression, prevention, treatments, and trial design.
Strong communication skills and demonstrated ability to work in a multi‑discipline team, using effective communication and taking personal accountability for timely delivery of results.
Prior experience with applications in pharmaceutical research and development is a plus.
Prior experience in Respiratory (e.g. COPD, IPF), Renal (e.g. CKD, nephrotoxicity), Hepatology (e.g. MASH) and/or Infectious diseases (e.g. HBV) is a plus.
Closing Date for Applications 16th of January, 2026 (COB)
Equal Opportunity Employer GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
Adjustments Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities, contact us at UKRecruitment.Adjustments@gsk.com where you can also request a call. Please note that if your enquiry does not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. Click the link where you will find answers to multiple questions we receive.
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This industrial QSP Postdoc position represents a unique opportunity for those with PhD, MD, PharmD or equivalent doctoral background, who have previous experience in mechanistic mathematical modelling to gain pharmaceutical industry experience of applying systems modelling and computational methodologies to drug discovery and development to advance the vision and mission of GSK's rapidly expanding Respiratory, Inflammation and Immunology Disease portfolio.
In this role you will
Build mechanistic mathematical models of biological, physiological, and pathophysiological processes to evaluate disease, its pathways and progression as well as drug action to prevent, treat and cure diseases; and conduct simulations of virtual patients to inform target and/or asset prioritisation and optimal trial design.
Develop and/or utilise state‑of‑the‑art mathematical tools, including knowledge of non‑linear dynamics, scientific ML and/or statistical techniques to gain insight into causal relationships between individual components of system‑level and drug‑level responses of drug‑target‑biomarker‑disease‑patient interaction.
Identify relevant question(s) of interest by working with disease area experts across different disciplines and address the question(s) by applying mechanistic and systems modelling.
Communicate and work in close collaboration with clinicians, biologists, clinical pharmacologists, pharmacometricians, statisticians, AIML, imaging, biomarker, genomics scientists and other cross‑matrix colleagues to inform research and development programmes and improve our understanding of disease mechanisms.
Promote transparency and communicate R&D achievements through publications in appropriate scientific journals.
Basic Qualifications & Skills
PhD, MD, or PharmD with experience in mechanistic modelling and simulation and systems biology.
Strong drive to quickly learn and build knowledge on a drug‑disease system, the mechanism, endpoints, progression, prevention, treatments, and trial design.
Strong communication skills and demonstrated ability to work in a multi‑discipline team, using effective communication and taking personal accountability for timely delivery of results.
Prior experience with applications in pharmaceutical research and development is a plus.
Prior experience in Respiratory (e.g. COPD, IPF), Renal (e.g. CKD, nephrotoxicity), Hepatology (e.g. MASH) and/or Infectious diseases (e.g. HBV) is a plus.
Closing Date for Applications 16th of January, 2026 (COB)
Equal Opportunity Employer GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
Adjustments Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities, contact us at UKRecruitment.Adjustments@gsk.com where you can also request a call. Please note that if your enquiry does not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. Click the link where you will find answers to multiple questions we receive.
#J-18808-Ljbffr