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The Fountain Group

Sequencing Platform Engineer

The Fountain Group, Santa Clara, California, us, 95053

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Details for the positionare as follows:

12-month contract to start with the possibility of extension or conversion depending on performance and business needs

Rate: $40-75 an hour – rate is dependent on years of experience and education level

Location: Santa Clara, CA 95050 – 100% onsite

Hours: M-F / 8AM-5PM

Job Description We are seeking a passionate and hands‑on Systems Engineer to join the Systems Development Group supporting next‑generation sequencing (NGS) products. This role is a key contributor across feasibility, development, system integration, verification, and customer support for end‑to‑end NGS solutions. The ideal candidate thrives in a multidisciplinary environment, enjoys solving complex technical problems, and maintains detailed documentation throughout all phases of research and development in alignment with regulatory and quality standards.

Become a subject‑matter expert in the operation of the Single Molecule Sequencing platform

Design, execute, and analyze wet‑lab experiments related to sample preparation, library preparation, and sequencing

Support system integration and testing activities; verify system performance using simulations, tests, and measurements

Develop, execute, and document verification and validation test cases, ensuring comprehensive coverage of product requirements

Assist with hardware development by testing and evaluating instrument subcomponents

Troubleshoot instrument failures and identify root causes, seeking specialized support when needed

Analyze experimental data, derive conclusions, and clearly document findings

Write SOPs, protocols, and technical reports for internal and cross‑functional teams

Provide customer support by monitoring sequencing runs, documenting defects, and following established escalation paths

Support reagent QC and system configurations used by customers

Required Skills

B.S., M.S., or PhD in science, chemistry, or engineering

1–5 years of relevant experience (depending on educational background)

Hands‑on laboratory experience required

Experience with PCR required

DNA sequencing experience required

Familiarity with MATLAB, Git, Python, or similar tools for data analysis or automation

Preferred Skills

3+ years of hands‑on NGS experience, including sample preparation, extraction, library prep, and sequencing

Strong understanding of DNA and molecular biology

Experience with PCR, laboratory automation, and a wide range of lab instrumentation

Proven troubleshooting experience in wet‑bench NGS workflows

Knowledge of the full NGS workflow, including nucleic acid chemistry and primer design

Experience with statistical tools (e.g., Python, JMP), regression analysis, ANOVA, Design of Experiments (DOE), and statistical process control

Exposure to prototype instruments, semiconductor‑based sensing devices, microfluidic devices, or surface chemistry is a plus

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