Charité - Universitätsmedizin Berlin
PhD Student (d/f/m) for translational Myeloma Research
Charité - Universitätsmedizin Berlin, Franklin, Tennessee, us, 37068
Responsibilities
Translational PhD project focused on identifying biomarkers that enable early prevention and prediction of the progression from myeloma precursor stages to active disease
Development and evaluation of targeted therapeutic strategies for patients with hard-to-treat myeloma
Perform a genome-wide cancer screen in CCND1- and MMSET-deregulated plasma cell tumors in a mouse model
Characterize resulting tumors in depth using a broad spectrum of bulk and single-cell analyses, with close collaboration and synergies with a parallel single-cell project from our group at the BIMSB
Validate the most promising candidate genes involved in myelomagenesis using preclinical models
Conduct subsequent mechanistic studies and translate findings into the human disease context, with the possibility of independently performing bioinformatic analyses
Application of a wide range of methods and technologies: mouse experiments, single-cell analyses, RNA/DNA sequencing, protein biochemistry, flow cytometry, CRISPR-Cas9 gene editing, bioinformatics/data science
Work with diverse model systems: genetically modified preclinical models (including mice), cell lines, primary patient material, and patient datasets
You are engaged in scientific work, and in accordance with §110 (4) sentence 3 of the BerlHG (Berlin Higher Education Act), an appropriate amount of time is granted to you for your own scientific qualification
Qualifications
Master’s degree (or equivalent) in biology, biochemistry, molecular medicine, computational biology, pharmacy, bioengineering, or a related field
High motivation, strong commitment, and excellent communication skills
Solid knowledge of molecular and cell biology
Excellent proficiency in English, both written and spoken
Desirable: prior experience with preclinical models (e.g., FELASA certificate) and/or bioinformatic analyses
#J-18808-Ljbffr
Translational PhD project focused on identifying biomarkers that enable early prevention and prediction of the progression from myeloma precursor stages to active disease
Development and evaluation of targeted therapeutic strategies for patients with hard-to-treat myeloma
Perform a genome-wide cancer screen in CCND1- and MMSET-deregulated plasma cell tumors in a mouse model
Characterize resulting tumors in depth using a broad spectrum of bulk and single-cell analyses, with close collaboration and synergies with a parallel single-cell project from our group at the BIMSB
Validate the most promising candidate genes involved in myelomagenesis using preclinical models
Conduct subsequent mechanistic studies and translate findings into the human disease context, with the possibility of independently performing bioinformatic analyses
Application of a wide range of methods and technologies: mouse experiments, single-cell analyses, RNA/DNA sequencing, protein biochemistry, flow cytometry, CRISPR-Cas9 gene editing, bioinformatics/data science
Work with diverse model systems: genetically modified preclinical models (including mice), cell lines, primary patient material, and patient datasets
You are engaged in scientific work, and in accordance with §110 (4) sentence 3 of the BerlHG (Berlin Higher Education Act), an appropriate amount of time is granted to you for your own scientific qualification
Qualifications
Master’s degree (or equivalent) in biology, biochemistry, molecular medicine, computational biology, pharmacy, bioengineering, or a related field
High motivation, strong commitment, and excellent communication skills
Solid knowledge of molecular and cell biology
Excellent proficiency in English, both written and spoken
Desirable: prior experience with preclinical models (e.g., FELASA certificate) and/or bioinformatic analyses
#J-18808-Ljbffr