Immunome, Inc.
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Associate Director, DMPK
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Immunome, Inc. 4 days ago Be among the first 25 applicants Join to apply for the
Associate Director, DMPK
role at
Immunome, Inc. Company Overview
Apply now, read the job details by scrolling down Double check you have the necessary skills before sending an application.
Immunome is a clinical-stage targeted oncology company committed to developing first- and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs.) Our most advanced pipeline programs are varegacestat (formerly AL102), a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors, IM-1021, a ROR1 ADC with an active IND, and IM-3050, a FAP-targeted radioligand, which is the subject of an IND expected to be submitted in the first quarter of 2025. Our pipeline also includes IM-1617, IM-1335, and IM-1340, all of which are preclinical ADCs pursuing undisclosed targets with expression in multiple solid tumors. Company Overview
Immunome is a clinical-stage targeted oncology company committed to developing first- and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs.) Our most advanced pipeline programs are varegacestat (formerly AL102), a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors, IM-1021, a ROR1 ADC with an active IND, and IM-3050, a FAP-targeted radioligand, which is the subject of an IND expected to be submitted in the first quarter of 2025. Our pipeline also includes IM-1617, IM-1335, and IM-1340, all of which are preclinical ADCs pursuing undisclosed targets with expression in multiple solid tumors.
Position Overview
The Associate Director, DMPK will develop and implement comprehensive plans to support optimal nonclinical pharmacokinetics/ADME packages for candidate drugs in all stages of research and development. In this role, they will lead the design, development, and implementation of DMPK plans for multiple oncology programs, enabling the optimal clinical development of candidate drugs. This role reports to the Executive Director, ADME.
Responsibilities
Proactively develops plans to provide stage specific data for all assets from research through regulatory submission for drug approval. Executes on plans to provide high quality data to support internal decision making and regulatory submissions. Actively partners with other functions and departments to ensure that programs are progressed seamlessly and efficiently through the development process. Represents the function at internal and external meetings, providing clear assessment of timelines, data, and impact to pipeline assets, including complex visualizations, to effectively communicate. Represents ADME function on project teams. Collaborates with Research project teams and within Translational Sciences/Development teams. Designs PK, TK, and PKPD studies, analyzes data, and conducts modeling and simulation, Interprets and translates data. Manages CROs for outsourced studies. Authors nonclinical pharmacokinetics sections of regulatory submissions and clinical protocols (e.g. INDs, IBs, CTDs, BLAs). Represents Immunome's science to external stakeholders
Qualification
A minimum of a PhD and 6+ years of industry experience, or MS/BS in a relevant scientific discipline and 10+ years of industry experience in the DMPK/ADME function. Experience with various drug modalities such as small molecules, large molecules, and ADCs, is required. Experience in the successful submission of at least three global filings (IND/NDA/BLA).
Knowledge And Skills
Industry DMPK sciences with various modalities such as ADC, small molecule, or monoclonal antibodies. Hands on PK/TK analysis and PKPD modeling. Experience in authoring relevant sections of global regulatory submissions. Excellent skills in assessment of the appropriate DMPK experiments to support clinical development at all stages of product development. Understanding of non-regulated and regulated bioanalysis. Excellent problem solving skills and the ability and desire to oversee multiple projects simultaneously in a fast-paced environment. Outstanding interpersonal and communication skills (written and oral) with the ability to communicate complex information succinctly.
Washington State Pay Range
$185,683 - $214,200 USD
E/E/O
Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.Seniority level
Seniority levelMid-Senior level Employment type
Employment typeFull-time Job function
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Associate Director, DMPK
role at
Immunome, Inc. 4 days ago Be among the first 25 applicants Join to apply for the
Associate Director, DMPK
role at
Immunome, Inc. Company Overview
Apply now, read the job details by scrolling down Double check you have the necessary skills before sending an application.
Immunome is a clinical-stage targeted oncology company committed to developing first- and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs.) Our most advanced pipeline programs are varegacestat (formerly AL102), a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors, IM-1021, a ROR1 ADC with an active IND, and IM-3050, a FAP-targeted radioligand, which is the subject of an IND expected to be submitted in the first quarter of 2025. Our pipeline also includes IM-1617, IM-1335, and IM-1340, all of which are preclinical ADCs pursuing undisclosed targets with expression in multiple solid tumors. Company Overview
Immunome is a clinical-stage targeted oncology company committed to developing first- and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs.) Our most advanced pipeline programs are varegacestat (formerly AL102), a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors, IM-1021, a ROR1 ADC with an active IND, and IM-3050, a FAP-targeted radioligand, which is the subject of an IND expected to be submitted in the first quarter of 2025. Our pipeline also includes IM-1617, IM-1335, and IM-1340, all of which are preclinical ADCs pursuing undisclosed targets with expression in multiple solid tumors.
Position Overview
The Associate Director, DMPK will develop and implement comprehensive plans to support optimal nonclinical pharmacokinetics/ADME packages for candidate drugs in all stages of research and development. In this role, they will lead the design, development, and implementation of DMPK plans for multiple oncology programs, enabling the optimal clinical development of candidate drugs. This role reports to the Executive Director, ADME.
Responsibilities
Proactively develops plans to provide stage specific data for all assets from research through regulatory submission for drug approval. Executes on plans to provide high quality data to support internal decision making and regulatory submissions. Actively partners with other functions and departments to ensure that programs are progressed seamlessly and efficiently through the development process. Represents the function at internal and external meetings, providing clear assessment of timelines, data, and impact to pipeline assets, including complex visualizations, to effectively communicate. Represents ADME function on project teams. Collaborates with Research project teams and within Translational Sciences/Development teams. Designs PK, TK, and PKPD studies, analyzes data, and conducts modeling and simulation, Interprets and translates data. Manages CROs for outsourced studies. Authors nonclinical pharmacokinetics sections of regulatory submissions and clinical protocols (e.g. INDs, IBs, CTDs, BLAs). Represents Immunome's science to external stakeholders
Qualification
A minimum of a PhD and 6+ years of industry experience, or MS/BS in a relevant scientific discipline and 10+ years of industry experience in the DMPK/ADME function. Experience with various drug modalities such as small molecules, large molecules, and ADCs, is required. Experience in the successful submission of at least three global filings (IND/NDA/BLA).
Knowledge And Skills
Industry DMPK sciences with various modalities such as ADC, small molecule, or monoclonal antibodies. Hands on PK/TK analysis and PKPD modeling. Experience in authoring relevant sections of global regulatory submissions. Excellent skills in assessment of the appropriate DMPK experiments to support clinical development at all stages of product development. Understanding of non-regulated and regulated bioanalysis. Excellent problem solving skills and the ability and desire to oversee multiple projects simultaneously in a fast-paced environment. Outstanding interpersonal and communication skills (written and oral) with the ability to communicate complex information succinctly.
Washington State Pay Range
$185,683 - $214,200 USD
E/E/O
Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.Seniority level
Seniority levelMid-Senior level Employment type
Employment typeFull-time Job function
Job functionBusiness Development and Sales Referrals increase your chances of interviewing at Immunome, Inc. by 2x Sign in to set job alerts for “Associate Director” roles.Associate Director, Events + Business OperationsSenior Customer Success Manager, Fashion and Fitness Seattle, WA $72,000.00-$154,000.00 2 days ago Senior Customer Success Manager, Fashion + FitnessAssistant/Associate Director, Student Engagement & Support - ( Staff | Student & Campus Life -VP | req2775 )Senior Supply Chain Manager, Amazon LogisticsAssistant/Associate Director, Student Engagement & Support Greater Seattle Area $111,000.00-$183,000.00 1 week ago Bellevue, WA $100,000.00-$120,000.00 4 months ago Associate Director Program Manager - Supply ChainRegional Key Customer Marketing (West Region) Associate DirectorAssociate Director of Information TechnologySenior Director of Operations - Everett, WATikTok Shop - Senior Product Manager, Marketing AutomationSenior Customer Success Manager, ConsumablesAssociate Director, Sourcing - Consumables Seattle, WA $125,300.00-$190,000.00 3 months ago Senior Customer Success Manager , Home & LifestyleSenior Supply Chain Manager, Amazon Business OperationsSenior Supply Chain Manager, Speed Improvement Team Bellevue, WA $103,900.00-$181,400.00 6 days ago We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
#J-18808-Ljbffr