Cytokinetics
Principal Scientist, DMPK
Cytokinetics - South San Francisco, California, us, 94083
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Principal Scientist, DMPK
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Principal Scientist, DMPK
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Cytokinetics Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility.
Make sure to read the full description below, and please apply immediately if you are confident you meet all the requirements.
At Cytokinetics, each team member plays an integral part in advancing our mission to improve the lives of patients. We are seeking tenacious, compassionate, and collaborative individuals who are driven to make a positive impact.
Responsibilities
Lead the design, execution, and interpretation of bioanalytical (BA) and pharmacokinetic (PK) studies to support preclinical and clinical development. Hand-on and oversee method development, validation, and sample analysis for small molecules, and/or novel modalities (e.g., siRNA, PROTAC) using Sciex LC-MS/MS, Orbitrap, or Q-TOF machines Perform non-compartmental (NCA) and compartmental PK analysis, PK/PD modeling, and translational pharmacokinetics to guide compound optimization and dosing strategies. Author and review technical reports, regulatory submissions (INDs, NDAs, BLAs), and scientific publications. Collaborate closely with toxicology, clinical pharmacology, CMC, and discovery teams to ensure suitable study design and robust PK/PD understanding of drug candidates. Leveraging specialized ADME/PK skills such as in vitro ADME, in vivo ADME, biotransformation, PK/PD, or physiologically-based pharmacokinetic modeling (PBPK) to impact project progression and decision-making Manage external CROs for bioanalytical and PK studies, ensuring data quality and regulatory compliance (GLP/GCP). Mentor junior scientists and contribute to departmental initiatives to enhance scientific and operational excellence. Capable of independently troubleshooting and resolving Sciex LC-MS/MS challenges as they arise in the lab.
Qualifications & Experience
PhD in Pharmacology, Pharmaceutical Sciences, Chemistry, or related field . 8+ years of relevant experience in bioanalytical sciences and pharmacokinetics within the pharmaceutical/biotech industry. Deep expertise in LC-MS/MS, Orbitrap, Q-TOF and HPLC methods. Strong background in PK modeling (WinNonlin, Phoenix, NONMEM, R, etc.) and interpretation of PK/PD data. Experience with regulatory submissions (FDA/EMA/ICH guidelines) and working in a GLP/GCP environment. Proven leadership skills with the ability to influence cross-functional teams and mentor junior scientists. Excellent communication, problem-solving, and project management abilities. Familiarity with DMPK principles (metabolism, transporters, drug-drug interactions). Knowledge of automation and high-throughput bioanalytical techniques.
Pay Range
In the U.S., the hiring pay range for fully qualified candidates is $213,750-$236,250 per year. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors.
Our employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you.
Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.
Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves.
Fraud Warning: How to Identify Impersonated Cytokinetics Job Postings and Offers
Recently, there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain (Cytokinetics.com) and will only be made after completing a formal interview process.
Here Are Some Ways To Check For Authenticity
We do not conduct job interviews through non-standard text messaging applications We will never request personal information such as banking details until after an official offer has been accepted and verified We will never request that you purchase equipment or other items when interviewing or hiring If you are unsure about the authenticity of an offer, or if you receive any suspicious communication, please contact us directly at talentacquisition@cytokinetics.com
Please visit our website at: www.cytokinetics.com
Cytokinetics is an Equal Opportunity Employer Seniority level
Seniority levelMid-Senior level Employment type
Employment typeFull-time Job function
Job functionResearch, Analyst, and Information Technology Referrals increase your chances of interviewing at Cytokinetics by 2x Sign in to set job alerts for “Principal Scientist” roles.Research Scientist - Computational Chemistry Oakland, CA $150,000.00-$200,000.00 3 weeks ago South San Francisco, CA $156,000.00-$296,500.00 2 weeks ago San Francisco Bay Area $55.00-$65.00 3 weeks ago Principal/Senior Scientist, Analytical ScienceSenior Staff Scientist, Medicinal Chemistry (industry experience required) South San Francisco, CA $170,000.00-$180,000.00 1 day ago Principal Scientist of Analytical Development San Francisco Bay Area $150,000.00-$170,000.00 3 weeks ago South San Francisco, CA $170,000.00-$200,000.00 1 month ago Scientist II or Senior Scientist: Mass Spectrometry Santa Cruz, CA $125,000.00-$172,000.00 1 week ago Senior Applied Scientist, Circuit and Fault Intelligence Palo Alto, CA $170,000.00-$190,000.00 2 weeks ago Senior Principal Research Scientist, Analytical Chemistry South San Francisco, CA $156,000.00-$296,500.00 2 weeks ago Development Lead - Principal Imaging Scientist IISr. Scientist, Small-Molecule Drug Substance Development and Manufacturing Hayward, CA $150,000.00-$170,000.00 5 days ago Senior Scientist II, Analytical Development Brisbane, CA $140,250.00-$216,500.00 1 week ago Research Scientist Manager - Reality LabsPolymer Formulation & Characterization - Scientist I-III/Senior/Lead Alameda, CA $110,000.00-$180,000.00 24 minutes ago Senior Decision Scientist - Growth Marketing San Jose, CA $120,000.00-$175,000.00 3 weeks ago Senior Scientist I, Biologics Drug Substance Development (Cell Culture Development) San Francisco, CA $136,000.00-$212,800.00 4 days ago Scientist 1/2/Senior Scientist, Analytical DevelopmentResearch Scientist Manager - Reality LabsSenior Geologist/Environmental Scientist/Senior Engineer San Francisco, CA $113,000.00-$195,200.00 6 days ago Senior Scientist - Chemical Development and Drug Substance ManufacturingTechnical Development Principal Scientist(Senior) Founding Scientist - Aptamers & Surface Chemistry for Wearable Biosensor Oakland, CA $125,000.00-$190,000.00 1 week ago We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
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Principal Scientist, DMPK
role at
Cytokinetics 2 weeks ago Be among the first 25 applicants Join to apply for the
Principal Scientist, DMPK
role at
Cytokinetics Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility.
Make sure to read the full description below, and please apply immediately if you are confident you meet all the requirements.
At Cytokinetics, each team member plays an integral part in advancing our mission to improve the lives of patients. We are seeking tenacious, compassionate, and collaborative individuals who are driven to make a positive impact.
Responsibilities
Lead the design, execution, and interpretation of bioanalytical (BA) and pharmacokinetic (PK) studies to support preclinical and clinical development. Hand-on and oversee method development, validation, and sample analysis for small molecules, and/or novel modalities (e.g., siRNA, PROTAC) using Sciex LC-MS/MS, Orbitrap, or Q-TOF machines Perform non-compartmental (NCA) and compartmental PK analysis, PK/PD modeling, and translational pharmacokinetics to guide compound optimization and dosing strategies. Author and review technical reports, regulatory submissions (INDs, NDAs, BLAs), and scientific publications. Collaborate closely with toxicology, clinical pharmacology, CMC, and discovery teams to ensure suitable study design and robust PK/PD understanding of drug candidates. Leveraging specialized ADME/PK skills such as in vitro ADME, in vivo ADME, biotransformation, PK/PD, or physiologically-based pharmacokinetic modeling (PBPK) to impact project progression and decision-making Manage external CROs for bioanalytical and PK studies, ensuring data quality and regulatory compliance (GLP/GCP). Mentor junior scientists and contribute to departmental initiatives to enhance scientific and operational excellence. Capable of independently troubleshooting and resolving Sciex LC-MS/MS challenges as they arise in the lab.
Qualifications & Experience
PhD in Pharmacology, Pharmaceutical Sciences, Chemistry, or related field . 8+ years of relevant experience in bioanalytical sciences and pharmacokinetics within the pharmaceutical/biotech industry. Deep expertise in LC-MS/MS, Orbitrap, Q-TOF and HPLC methods. Strong background in PK modeling (WinNonlin, Phoenix, NONMEM, R, etc.) and interpretation of PK/PD data. Experience with regulatory submissions (FDA/EMA/ICH guidelines) and working in a GLP/GCP environment. Proven leadership skills with the ability to influence cross-functional teams and mentor junior scientists. Excellent communication, problem-solving, and project management abilities. Familiarity with DMPK principles (metabolism, transporters, drug-drug interactions). Knowledge of automation and high-throughput bioanalytical techniques.
Pay Range
In the U.S., the hiring pay range for fully qualified candidates is $213,750-$236,250 per year. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors.
Our employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you.
Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.
Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves.
Fraud Warning: How to Identify Impersonated Cytokinetics Job Postings and Offers
Recently, there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain (Cytokinetics.com) and will only be made after completing a formal interview process.
Here Are Some Ways To Check For Authenticity
We do not conduct job interviews through non-standard text messaging applications We will never request personal information such as banking details until after an official offer has been accepted and verified We will never request that you purchase equipment or other items when interviewing or hiring If you are unsure about the authenticity of an offer, or if you receive any suspicious communication, please contact us directly at talentacquisition@cytokinetics.com
Please visit our website at: www.cytokinetics.com
Cytokinetics is an Equal Opportunity Employer Seniority level
Seniority levelMid-Senior level Employment type
Employment typeFull-time Job function
Job functionResearch, Analyst, and Information Technology Referrals increase your chances of interviewing at Cytokinetics by 2x Sign in to set job alerts for “Principal Scientist” roles.Research Scientist - Computational Chemistry Oakland, CA $150,000.00-$200,000.00 3 weeks ago South San Francisco, CA $156,000.00-$296,500.00 2 weeks ago San Francisco Bay Area $55.00-$65.00 3 weeks ago Principal/Senior Scientist, Analytical ScienceSenior Staff Scientist, Medicinal Chemistry (industry experience required) South San Francisco, CA $170,000.00-$180,000.00 1 day ago Principal Scientist of Analytical Development San Francisco Bay Area $150,000.00-$170,000.00 3 weeks ago South San Francisco, CA $170,000.00-$200,000.00 1 month ago Scientist II or Senior Scientist: Mass Spectrometry Santa Cruz, CA $125,000.00-$172,000.00 1 week ago Senior Applied Scientist, Circuit and Fault Intelligence Palo Alto, CA $170,000.00-$190,000.00 2 weeks ago Senior Principal Research Scientist, Analytical Chemistry South San Francisco, CA $156,000.00-$296,500.00 2 weeks ago Development Lead - Principal Imaging Scientist IISr. Scientist, Small-Molecule Drug Substance Development and Manufacturing Hayward, CA $150,000.00-$170,000.00 5 days ago Senior Scientist II, Analytical Development Brisbane, CA $140,250.00-$216,500.00 1 week ago Research Scientist Manager - Reality LabsPolymer Formulation & Characterization - Scientist I-III/Senior/Lead Alameda, CA $110,000.00-$180,000.00 24 minutes ago Senior Decision Scientist - Growth Marketing San Jose, CA $120,000.00-$175,000.00 3 weeks ago Senior Scientist I, Biologics Drug Substance Development (Cell Culture Development) San Francisco, CA $136,000.00-$212,800.00 4 days ago Scientist 1/2/Senior Scientist, Analytical DevelopmentResearch Scientist Manager - Reality LabsSenior Geologist/Environmental Scientist/Senior Engineer San Francisco, CA $113,000.00-$195,200.00 6 days ago Senior Scientist - Chemical Development and Drug Substance ManufacturingTechnical Development Principal Scientist(Senior) Founding Scientist - Aptamers & Surface Chemistry for Wearable Biosensor Oakland, CA $125,000.00-$190,000.00 1 week ago We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
#J-18808-Ljbffr