GlaxoSmithKline
Principal Scientist, In Vivo Tumor Model Oncology Drug Discovery
GlaxoSmithKline, Cambridge, Massachusetts, us, 02140
Overview
The Oncology Intracellular Targeted Cancer Therapeutics Unit has an opening for an In Vivo Principal Scientist at its Cambridge, MA site. The successful candidate will work with a highly motivated team to discover and develop novel oncology drugs with a clear genetic relationship to cancer. The primary responsibility of this position is to represent in vivo pharmacology in project teams and lead the in vivo strategy to advance the program. The candidate should be able to independently execute a variety of in vivo techniques to evaluate a compound in mouse tumor models and deliver high-quality data. The candidate must be proficient in planning, executing and analyzing data to effectively achieve project goals and timelines. Responsibilities
The following responsibilities include opportunities to lead key activities and develop your career: To be the in vivo lead for early-stage discovery programs and be responsible for generating in vivo proof of concept data for anti-tumor efficacy in genetically relevant tumor models. Work with the project team to generate efficacy-PK-PD correlation for the lead compound. Share data with the project team and in other internal or external forums. End-to-end execution of the in vivo tumor model studies including in-life portion, data analysis and recording. Work in compliance with institutional animal welfare guidelines for the use of animals in research. Write study reports for regulatory submissions. Basic Qualifications
We are looking for professionals with these required skills to achieve our goals: Doctorate / PhD in Cell Biology, Molecular Biology, Biochemistry, Pharmacology, or related life sciences field. 1+ years of experience with design, conduct, and analysis of data from in vivo pharmacology studies. Experience working with in vivo tumor models (CDX - cell line derived, PDX - patient derived and Syngeneic mouse models). Experience managing multiple priorities in a matrix environment. Preferred Qualifications
If you have the following characteristics, it would be a plus: Knowledge of translationally relevant tumor models in both solid and hematologic tumor space. Demonstrated expertise including PK/PD, efficacy and biomarker studies to inform patient selection strategies, dose and schedule optimization, and identify rationale drug combinations. Experience in techniques including cell culture, compound preparation and formulation, administration to mice (i.v., s.c., p.o.), tumor implantation and measurements. Data analytical skills using Prism GraphPad or other software. Ability to lead from the bench in problem solving and the development of innovative solutions. Excellent communication and presentation skills. A proven track record of high productivity and scientific publications in peer-reviewed journals. Speaks, writes, and listens effectively. Excellent record-keeping and organization skills. The position is available in Cambridge, MA, USA. #GSK-LI Please note: GSK is an Equal Opportunity Employer and does not discriminate on the basis of race, color, religion, sex, national origin, age, disability or any other protected status. If you require accommodation or assistance to apply, contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is not accepting referrals from employment businesses and/or employment agencies for vacancies posted on this site without prior written authorization from GSK. This notice is part of our standard recruitment process. For more information about employer transparency requirements, please visit the CMS Open Payments data site.
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The Oncology Intracellular Targeted Cancer Therapeutics Unit has an opening for an In Vivo Principal Scientist at its Cambridge, MA site. The successful candidate will work with a highly motivated team to discover and develop novel oncology drugs with a clear genetic relationship to cancer. The primary responsibility of this position is to represent in vivo pharmacology in project teams and lead the in vivo strategy to advance the program. The candidate should be able to independently execute a variety of in vivo techniques to evaluate a compound in mouse tumor models and deliver high-quality data. The candidate must be proficient in planning, executing and analyzing data to effectively achieve project goals and timelines. Responsibilities
The following responsibilities include opportunities to lead key activities and develop your career: To be the in vivo lead for early-stage discovery programs and be responsible for generating in vivo proof of concept data for anti-tumor efficacy in genetically relevant tumor models. Work with the project team to generate efficacy-PK-PD correlation for the lead compound. Share data with the project team and in other internal or external forums. End-to-end execution of the in vivo tumor model studies including in-life portion, data analysis and recording. Work in compliance with institutional animal welfare guidelines for the use of animals in research. Write study reports for regulatory submissions. Basic Qualifications
We are looking for professionals with these required skills to achieve our goals: Doctorate / PhD in Cell Biology, Molecular Biology, Biochemistry, Pharmacology, or related life sciences field. 1+ years of experience with design, conduct, and analysis of data from in vivo pharmacology studies. Experience working with in vivo tumor models (CDX - cell line derived, PDX - patient derived and Syngeneic mouse models). Experience managing multiple priorities in a matrix environment. Preferred Qualifications
If you have the following characteristics, it would be a plus: Knowledge of translationally relevant tumor models in both solid and hematologic tumor space. Demonstrated expertise including PK/PD, efficacy and biomarker studies to inform patient selection strategies, dose and schedule optimization, and identify rationale drug combinations. Experience in techniques including cell culture, compound preparation and formulation, administration to mice (i.v., s.c., p.o.), tumor implantation and measurements. Data analytical skills using Prism GraphPad or other software. Ability to lead from the bench in problem solving and the development of innovative solutions. Excellent communication and presentation skills. A proven track record of high productivity and scientific publications in peer-reviewed journals. Speaks, writes, and listens effectively. Excellent record-keeping and organization skills. The position is available in Cambridge, MA, USA. #GSK-LI Please note: GSK is an Equal Opportunity Employer and does not discriminate on the basis of race, color, religion, sex, national origin, age, disability or any other protected status. If you require accommodation or assistance to apply, contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is not accepting referrals from employment businesses and/or employment agencies for vacancies posted on this site without prior written authorization from GSK. This notice is part of our standard recruitment process. For more information about employer transparency requirements, please visit the CMS Open Payments data site.
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