GSK
Principal Scientist, In Vivo Tumor Model Oncology Drug Discovery
GSK, Cambridge, Massachusetts, us, 02140
Overview
The Oncology Intracellular Targeted Cancer Therapeutics Unit has an opening for an In Vivo Principal Scientist at its Cambridge, MA site. The successful candidate will work with a highly motivated team to discover and develop novel oncology drugs with a clear genetic relationship to cancer.
Responsibilities
To be the in vivo lead for early-stage discovery programs and be responsible for generating in vivo proof of concept data for anti-tumor efficacy in genetically relevant tumor models.
Work with the project team to generate efficacy-PK-PD correlation for the lead compound.
Share data with the project team and at other internal or external forums.
Responsible for end-to-end execution of the in vivo tumor model studies including the in-life portion, data analysis and recording.
Works in compliance with GSK’s institutional animal welfare guidelines for the use of animals in research.
Writing study reports for regulatory submissions.
Basic Qualifications
Doctorate / PhD
in Cell Biology, Molecular Biology, Biochemistry, Pharmacology, or related life sciences field
1+ years of experience with design, conduct, and analyze data from in vivo pharmacology studies.
Experience in working with in vivo tumor models (CDX - Cell line derived, PDX - Patient derived and Syngeneic mouse models).
Experience managing multiple priorities in a matrix environment.
Preferred Qualifications
Knowledge of translationally relevant tumor models in both solid and hematologic tumor space
Demonstrated expertise including PK/PD, efficacy and biomarker studies to inform patient selection strategies, dose and schedule optimization, and identify rationale drug combinations.
Experience in techniques including cell culture, compound preparation and formulation, administration to mice (i.v., s.c., p.o.), tumor implantation and measurements.
Data analytical skills using Prism GraphPad or other software.
Ability to lead from the bench in problem solving and the development of innovative solutions.
Excellent communication and presentation skills.
A proven track record of high productivity and scientific publications in peer-reviewed journals.
Speaks, writes, and listens effectively.
Excellent record-keeping and organization skills.
The position is available in Cambridge, MA, USA.
Please visit the GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
Why GSK? Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
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Responsibilities
To be the in vivo lead for early-stage discovery programs and be responsible for generating in vivo proof of concept data for anti-tumor efficacy in genetically relevant tumor models.
Work with the project team to generate efficacy-PK-PD correlation for the lead compound.
Share data with the project team and at other internal or external forums.
Responsible for end-to-end execution of the in vivo tumor model studies including the in-life portion, data analysis and recording.
Works in compliance with GSK’s institutional animal welfare guidelines for the use of animals in research.
Writing study reports for regulatory submissions.
Basic Qualifications
Doctorate / PhD
in Cell Biology, Molecular Biology, Biochemistry, Pharmacology, or related life sciences field
1+ years of experience with design, conduct, and analyze data from in vivo pharmacology studies.
Experience in working with in vivo tumor models (CDX - Cell line derived, PDX - Patient derived and Syngeneic mouse models).
Experience managing multiple priorities in a matrix environment.
Preferred Qualifications
Knowledge of translationally relevant tumor models in both solid and hematologic tumor space
Demonstrated expertise including PK/PD, efficacy and biomarker studies to inform patient selection strategies, dose and schedule optimization, and identify rationale drug combinations.
Experience in techniques including cell culture, compound preparation and formulation, administration to mice (i.v., s.c., p.o.), tumor implantation and measurements.
Data analytical skills using Prism GraphPad or other software.
Ability to lead from the bench in problem solving and the development of innovative solutions.
Excellent communication and presentation skills.
A proven track record of high productivity and scientific publications in peer-reviewed journals.
Speaks, writes, and listens effectively.
Excellent record-keeping and organization skills.
The position is available in Cambridge, MA, USA.
Please visit the GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
Why GSK? Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
#J-18808-Ljbffr