Thermo Fisher Scientific
Overview
Join to apply for the
Research Scientist - LCMS / mRNA
role at
Thermo Fisher Scientific . At Thermo Fisher Scientific, you’ll discover meaningful work that makes a positive impact on a global scale. Our mission is to enable customers to make the world healthier, cleaner and safer, through clinical research, laboratory, digital and decentralized clinical trial services. The Analytical Services team provides a functional service provider solution allowing you to gain direct experience onsite at a pharmaceutical/biopharmaceutical company while maintaining full-time benefits.
Responsibilities
Develop advanced and robust LC-MS analytical methods on mRNA payload identity, including 5’ Cap identity and capping efficiency, mRNA sequence and chemical modification identity, and 3’ poly(A) tail length and identity.
Optimize RNA biochemical assays to digest mRNA to evaluate 5’ Cap structure and generate high quality LC-MS data (MS1 and MS2).
Test optimized RNA digestion and LC-MS protocols on commercially available mRNA and in-house produced mRNA payloads.
Review and process complex LC-MS data using workflows (e.g., BioPharma Finder); interpret results, build data visualizations, and communicate results to the team.
Train team members on sample preparation, LC-MS data generation/analysis, and troubleshooting RNA LC-MS analysis.
Perform sample testing for lipid raw materials, protein ligands, and LNP formulations.
Present findings to the GEnD team and disease project team to inform decision making and next steps.
Maintain LC-MS instruments and order reagents and supplies as needed.
Maintain and document records of all experiments, including methods and results, in electronic laboratory notebooks.
Apply knowledge of additional mRNA analytics (e.g., HPLC, CE) as applicable.
Education and Experience
Bachelor's degree in Chemistry, Biochemistry, Materials Science, Immunology, Biology, Molecular Biology or related field.
ARS: 6+ years’ equivalent experience (or equivalent)
OR Master’s degree with 4+ years’ equivalent experience
OR PhD with 2+ years’ equivalent experience
Equivalency of education, training, and/or related experience may be considered sufficient for the role.
Knowledge, Skills and Abilities
Extensive experience in LC-MS method development and sample testing; RNA analysis experience preferred.
Extensive experience in MS data analysis.
Experience with LNP, lipid, and/or RNA is highly desired.
Experience with Waters Acquity Premier UPLC and Thermo Fisher Orbitrap Exploris 240.
Proficiency in data analysis software (e.g., Xcalibur, Chromeleon, Empower).
Working Environment Ability to communicate with diverse groups, work in office and laboratory settings, and use standard equipment. May involve lifting up to 25 pounds and exposure to potentially hazardous elements in healthcare or laboratory environments. Ability to work under pressure while managing multiple projects.
Benefits Competitive remuneration, annual incentive plan bonus, healthcare, and a range of employee benefits. The organization emphasizes integrity, intensity, involvement, and innovation.
Seniority level
Not Applicable
Employment type
Full-time
Job function
Research, Science, and Engineering
Industries
Pharmaceutical Manufacturing and Biotechnology Research
#J-18808-Ljbffr
Join to apply for the
Research Scientist - LCMS / mRNA
role at
Thermo Fisher Scientific . At Thermo Fisher Scientific, you’ll discover meaningful work that makes a positive impact on a global scale. Our mission is to enable customers to make the world healthier, cleaner and safer, through clinical research, laboratory, digital and decentralized clinical trial services. The Analytical Services team provides a functional service provider solution allowing you to gain direct experience onsite at a pharmaceutical/biopharmaceutical company while maintaining full-time benefits.
Responsibilities
Develop advanced and robust LC-MS analytical methods on mRNA payload identity, including 5’ Cap identity and capping efficiency, mRNA sequence and chemical modification identity, and 3’ poly(A) tail length and identity.
Optimize RNA biochemical assays to digest mRNA to evaluate 5’ Cap structure and generate high quality LC-MS data (MS1 and MS2).
Test optimized RNA digestion and LC-MS protocols on commercially available mRNA and in-house produced mRNA payloads.
Review and process complex LC-MS data using workflows (e.g., BioPharma Finder); interpret results, build data visualizations, and communicate results to the team.
Train team members on sample preparation, LC-MS data generation/analysis, and troubleshooting RNA LC-MS analysis.
Perform sample testing for lipid raw materials, protein ligands, and LNP formulations.
Present findings to the GEnD team and disease project team to inform decision making and next steps.
Maintain LC-MS instruments and order reagents and supplies as needed.
Maintain and document records of all experiments, including methods and results, in electronic laboratory notebooks.
Apply knowledge of additional mRNA analytics (e.g., HPLC, CE) as applicable.
Education and Experience
Bachelor's degree in Chemistry, Biochemistry, Materials Science, Immunology, Biology, Molecular Biology or related field.
ARS: 6+ years’ equivalent experience (or equivalent)
OR Master’s degree with 4+ years’ equivalent experience
OR PhD with 2+ years’ equivalent experience
Equivalency of education, training, and/or related experience may be considered sufficient for the role.
Knowledge, Skills and Abilities
Extensive experience in LC-MS method development and sample testing; RNA analysis experience preferred.
Extensive experience in MS data analysis.
Experience with LNP, lipid, and/or RNA is highly desired.
Experience with Waters Acquity Premier UPLC and Thermo Fisher Orbitrap Exploris 240.
Proficiency in data analysis software (e.g., Xcalibur, Chromeleon, Empower).
Working Environment Ability to communicate with diverse groups, work in office and laboratory settings, and use standard equipment. May involve lifting up to 25 pounds and exposure to potentially hazardous elements in healthcare or laboratory environments. Ability to work under pressure while managing multiple projects.
Benefits Competitive remuneration, annual incentive plan bonus, healthcare, and a range of employee benefits. The organization emphasizes integrity, intensity, involvement, and innovation.
Seniority level
Not Applicable
Employment type
Full-time
Job function
Research, Science, and Engineering
Industries
Pharmaceutical Manufacturing and Biotechnology Research
#J-18808-Ljbffr