Net2Source (N2S)
Scientist I, Oligonucleotide Analytics
Net2Source (N2S), San Diego, California, United States, 92189
1 day ago Be among the first 25 applicants
This range is provided by Net2Source (N2S). Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.
Base pay range
$48.00/hr - $52.00/hr Direct message the job poster from Net2Source (N2S) Job Title: Scientist I, Oligonucleotide Analytics 100% Onsite Duration: 12 months contract Notes from HM: - PhD is required - Must have experience with Analytical Chemistry - Must have experience with Oligonucleotides - Must have siRNA experience - Previous gene therapy experience - Must have 1-3 years of experience - Experience with Chromatography (LC-MS) - Experience with these instruments: Thermo LTQ, LC/MS or Thermo Orbitrap LC/MS Key Responsibilities
Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS. Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput. Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography. Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization Support integrity confirmation requests (such as concentration) by assay development and biology teams Conduct QC for lipid nanoparticle (LNP) formulations of mRNA Ensure the supply of laboratory consumables and reagents are in stock as needed Maintain a high level of productivity in the laboratory setting. Present data and reports on project status at individual, group, and departmental meetings. Qualifications
Ph.D. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required. Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required. Top Three Skills:
Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughput analytical capabilities Seniority level
Mid-Senior level Employment type
Contract Job function
Science and Research Industries
Pharmaceutical Manufacturing, Medical Equipment Manufacturing, and Biotechnology Research Referrals increase your chances of interviewing at Net2Source (N2S) by 2x Get notified about new Scientist jobs in
San Diego, CA . San Diego, CA $52,000 - $55,000 23 hours ago We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
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$48.00/hr - $52.00/hr Direct message the job poster from Net2Source (N2S) Job Title: Scientist I, Oligonucleotide Analytics 100% Onsite Duration: 12 months contract Notes from HM: - PhD is required - Must have experience with Analytical Chemistry - Must have experience with Oligonucleotides - Must have siRNA experience - Previous gene therapy experience - Must have 1-3 years of experience - Experience with Chromatography (LC-MS) - Experience with these instruments: Thermo LTQ, LC/MS or Thermo Orbitrap LC/MS Key Responsibilities
Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS. Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput. Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography. Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization Support integrity confirmation requests (such as concentration) by assay development and biology teams Conduct QC for lipid nanoparticle (LNP) formulations of mRNA Ensure the supply of laboratory consumables and reagents are in stock as needed Maintain a high level of productivity in the laboratory setting. Present data and reports on project status at individual, group, and departmental meetings. Qualifications
Ph.D. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required. Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required. Top Three Skills:
Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughput analytical capabilities Seniority level
Mid-Senior level Employment type
Contract Job function
Science and Research Industries
Pharmaceutical Manufacturing, Medical Equipment Manufacturing, and Biotechnology Research Referrals increase your chances of interviewing at Net2Source (N2S) by 2x Get notified about new Scientist jobs in
San Diego, CA . San Diego, CA $52,000 - $55,000 23 hours ago We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
#J-18808-Ljbffr