Associate Scientist/Scientist in Protein Science

Associate Scientist/Scientist in Protein Science Title: Associate Scientist/Scientist Location: Bay Area (On-site) Keywords: Protein Science, Protein Engineering General Summary We are seeking a skilled scientist in Associate Scientist to Scientist level with a background in Protein Science and Structural Biology in the Bioengineering Department at BioMap. This position will mainly focus on recombinant protein/enzyme production and characterization, computation-aided library generation, high-throughput screening, and structural biology. We are a multi-disciplinary team working closely with computational scientists on mini-binders, nanobodies, antibodies, and enzymes, supporting the discovery of bio-therapeutics through our engineering expertise. The successful candidate has a background within protein science and structural biology, and preferably experience with membrane protein production, protein characterization and HT display methodologies. This is a wonderful opportunity to work with world-class biologists, AI/ML scientists, and engineers to explore the next-generation therapeutical drug development. Job Responsibilities Generate high quality antigens for protein engineering campaigns in various host cells, with focus on the HEK and CHO cell systems.

· Work closely with other scientists on protein/enzyme engineering projects by using display technologies, NGS, flow cytometry, liquid handler, microplate reading, etc. · Help design the DNA constructs, and generate the synthetic DNA library by molecular biology techniques, including RT-PCR, gene cloning, mammalian cell transfection, etc. · Analyze libraries by FACS sorting and NGS to screen for lead candidates. · Assist the HTP protein/enzyme characterization and in vitro/in vivo assay development. · Collaborate with cross-functional teams for project development. · Routine laboratory instruments maintenance, including mammalian cell cultures, AKTA, HPLC, etc. · Demonstrate ability to combine, analyze, and visualize data from multiple sources. · Attend internal and external meeting to represent the department or company for project presentation. Qualifications · A Master's or a Ph.D's degree within subject matter expertise are preferred. · Recombinant protein and enzyme production in mammalian or insect cells, experience on protein purification system (such as AKTA) and protein characterization (SPR/BLI, functional validation). · Experience with membrane protein generation (preferring nanodiscs format). · Good understanding of antibody and enzyme science · Experience with different protein formats, such as antibody, nanobody, mini-binder, and enzyme. · Experience with cell-based compound characterization, microscopy, mammalian cell display technologies, Flow cytometry, NGS is a plus. · Experience with therapeutic drug development is a plus. · Familiar with industrial working standards, including LIMS. · Demonstrates excellent verbal and written communication skills. · Good working attitude in a fast-growing organization. Applications Please send your CV with subject of Associate Scientist/Scientist in Protein Science to talent@biomap.com.