BioSpace
Overview
Scientist (Seattle, WA) at Regeneron Pharmaceuticals, Inc. to assist with researching literature and market landscape to identify potential therapeutic targets and associated product concepts. Devise experimental plans to validate identified targets. Generate libraries of immunotherapeutic proteins and perform assay-based screening to identify promising hits. 4% domestic travel required. Responsibilities
Generate libraries of immunotherapeutic proteins and perform assay-based screening to identify promising hits. Perform standard T cell characterization assays, including cocultures to evaluate antigen specificity, target cell cytotoxicity, and T cell proliferation. Analyze high-throughput data using bioinformatics workflows in R and adjust parameters as necessary. Employ state-of-the-art automation instruments and collaborate with automation scientists to refine protocols. Provide guidance and mentorship to junior interns. Interpret and present data at working groups to help the broader department make data-driven decisions. Travel as required (4% domestic). Qualifications
Bachelor's degree in Cell and Molecular Biology, Immunology, Biochemistry, Biology or related field with 3 years of pharmaceutical/biotech industry research experience; or a Master’s degree in these fields with 1 year of specified experience. Experience with: cell signaling pathways, protein engineering and cancer immunotherapies; molecular biology techniques including DNA construct design and cloning (including large-scale library cloning and quality assessment via Next-Generation Sequencing); mammalian cell culture and cell line engineering by CRISPR-Cas9; automation platforms (e.g., Hamilton and Integra Assist Plus); multicolor flow cytometry and FACS; data analysis with FlowJo and GraphPad Prism; bioinformatics analysis of sequence data using R and/or Python. Ability to drive multiple projects simultaneously and present results effectively in team settings. Scientific publications in the pharmaceutical/biotech industry research field. Note: Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief, sex, nationality, national or ethnic origin, civil status, age, citizenship status, pregnancy or parental status, gender identity, gender reassignment, disability, or any other protected characteristic in accordance with applicable laws and regulations. Reasonable accommodation will be provided to known disabilities or chronic illnesses of an otherwise qualified applicant, unless the accommodation would impose undue hardship on operation of the business. Compensation and Benefits
Salary range information and benefits vary by location. See Regeneron total rewards details for specifics. To apply, visit the Regeneron careers site. Reference code: R40083.
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Scientist (Seattle, WA) at Regeneron Pharmaceuticals, Inc. to assist with researching literature and market landscape to identify potential therapeutic targets and associated product concepts. Devise experimental plans to validate identified targets. Generate libraries of immunotherapeutic proteins and perform assay-based screening to identify promising hits. 4% domestic travel required. Responsibilities
Generate libraries of immunotherapeutic proteins and perform assay-based screening to identify promising hits. Perform standard T cell characterization assays, including cocultures to evaluate antigen specificity, target cell cytotoxicity, and T cell proliferation. Analyze high-throughput data using bioinformatics workflows in R and adjust parameters as necessary. Employ state-of-the-art automation instruments and collaborate with automation scientists to refine protocols. Provide guidance and mentorship to junior interns. Interpret and present data at working groups to help the broader department make data-driven decisions. Travel as required (4% domestic). Qualifications
Bachelor's degree in Cell and Molecular Biology, Immunology, Biochemistry, Biology or related field with 3 years of pharmaceutical/biotech industry research experience; or a Master’s degree in these fields with 1 year of specified experience. Experience with: cell signaling pathways, protein engineering and cancer immunotherapies; molecular biology techniques including DNA construct design and cloning (including large-scale library cloning and quality assessment via Next-Generation Sequencing); mammalian cell culture and cell line engineering by CRISPR-Cas9; automation platforms (e.g., Hamilton and Integra Assist Plus); multicolor flow cytometry and FACS; data analysis with FlowJo and GraphPad Prism; bioinformatics analysis of sequence data using R and/or Python. Ability to drive multiple projects simultaneously and present results effectively in team settings. Scientific publications in the pharmaceutical/biotech industry research field. Note: Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief, sex, nationality, national or ethnic origin, civil status, age, citizenship status, pregnancy or parental status, gender identity, gender reassignment, disability, or any other protected characteristic in accordance with applicable laws and regulations. Reasonable accommodation will be provided to known disabilities or chronic illnesses of an otherwise qualified applicant, unless the accommodation would impose undue hardship on operation of the business. Compensation and Benefits
Salary range information and benefits vary by location. See Regeneron total rewards details for specifics. To apply, visit the Regeneron careers site. Reference code: R40083.
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