St Jude Children's Research Hospital
Principal Scientist in Chemical Induced Proximity
St Jude Children's Research Hospital, Memphis, Tennessee, us, 37544
Overview
We are seeking a highly motivated and innovative Principal Scientist with specialized expertise in drug discovery to direct our Chemical Induced Proximity Center in the Department of Chemical Biology and Therapeutics at St. Jude Children\'s Research Hospital. This senior leadership role focuses on advancing cutting-edge drug discovery programs using proximity-based targeting, including protein degraders, synthetic gene regulators, and other functional effectors, to address pediatric diseases such as oncology, neurodegenerative disorders, and sickle cell disease. The World\'s Brightest Minds Always Innovate We provide world-class facilities, state-of-the-art technologies, extraordinary support, and a bench-to-bedside environment where science translates into survival for the children we serve. We encourage dream-big, with no barriers to finding cures and saving children. Responsibilities
Set up the chemistry strategy for projects and advance drug discovery programs by collaboratively interacting cross-functionally within departmental collaborative centers and various departments at the institution. Lead and manage a team of scientists and large-scale, multidisciplinary projects through proactive research collaboration, and provide direction in specific area of expertise. Contribute to recruiting and growing the team, guiding and mentoring junior staff. Stay at the forefront of induced proximity platforms, including but not limited to PROTACs, molecular glues, and other bifunctional or allosteric modulators. Evaluate new technologies, chemical tools, and screening platforms that can accelerate the development of proximity-based therapeutics. Design and optimize focused chemical libraries to identify hits, leads, and drug candidates that induce selective protein interactions and cellular phenotypic changes. Maintain collaborative partnerships while ensuring recognition on collaborating publications and patents. Lead and manage contract research organizations (CRO) and external chemistry partners across the globe. Oversee structure-activity relationship (SAR) studies to enhance potency, selectivity, and drug-like properties of candidate molecules. Lead efforts to improve pharmacokinetic, pharmacodynamic, and toxicological profiles of compounds in collaboration with ADMET and DMPK teams. Serve as functional expert in due diligences for assets in-licensing and discovery partnerships. Lead publication efforts in high-impact scientific journals. Relevant experience in pharma/biotech drug discovery is highly preferred; experience with computational design or AI/ML is preferred. PhD with management experience is preferred. Minimum Education and Experience
Bachelor\'s degree in a relevant scientific area is required. PhD is preferred. Experience Requirements
Fifteen (15) years of relevant work experience required with a Bachelor\'s degree. Thirteen (13) years of relevant work experience required with a Master\'s degree. Ten (10) years of relevant work experience required with a PhD. Compensation and Benefits
We offer a competitive compensation range and benefits package. A reasonable estimate of the current salary range is $138,320 - $262,080 per year for the role of Principal Scientist in Chemical Induced Proximity. This is an estimate and final offers consider factors such as skill sets, experience, training, and organizational needs. We also provide comprehensive benefits including medical, dental, vision, retirement, wellness programs, time-off, and educational benefits. Benefits
Your health and well-being are important to us. St. Jude provides high-quality benefits choices and coverage for employees and dependents. View all benefits including Medical & Prescription Drug Plans, Dental, Vision, Financial Security, Retirement, Living Well – Employee Wellness Program, Time Off Programs, Educational Benefits, Family Friendly Benefits, and Benefits Unique to St. Jude. About Memphis
Memphis offers big-city amenities with a small-town feel. Our region has a lower cost of living than the national average, no state personal income tax on wages, and a shorter average commute. Learn how you can “Have More in Memphis.” Equal Opportunity and Hiring
St. Jude is an Equal Opportunity Employer. No Search Firms. St. Jude does not accept unsolicited assistance from search firms for employment opportunities. Resumes submitted by search firms without a valid written agreement will not be paid a fee.
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We are seeking a highly motivated and innovative Principal Scientist with specialized expertise in drug discovery to direct our Chemical Induced Proximity Center in the Department of Chemical Biology and Therapeutics at St. Jude Children\'s Research Hospital. This senior leadership role focuses on advancing cutting-edge drug discovery programs using proximity-based targeting, including protein degraders, synthetic gene regulators, and other functional effectors, to address pediatric diseases such as oncology, neurodegenerative disorders, and sickle cell disease. The World\'s Brightest Minds Always Innovate We provide world-class facilities, state-of-the-art technologies, extraordinary support, and a bench-to-bedside environment where science translates into survival for the children we serve. We encourage dream-big, with no barriers to finding cures and saving children. Responsibilities
Set up the chemistry strategy for projects and advance drug discovery programs by collaboratively interacting cross-functionally within departmental collaborative centers and various departments at the institution. Lead and manage a team of scientists and large-scale, multidisciplinary projects through proactive research collaboration, and provide direction in specific area of expertise. Contribute to recruiting and growing the team, guiding and mentoring junior staff. Stay at the forefront of induced proximity platforms, including but not limited to PROTACs, molecular glues, and other bifunctional or allosteric modulators. Evaluate new technologies, chemical tools, and screening platforms that can accelerate the development of proximity-based therapeutics. Design and optimize focused chemical libraries to identify hits, leads, and drug candidates that induce selective protein interactions and cellular phenotypic changes. Maintain collaborative partnerships while ensuring recognition on collaborating publications and patents. Lead and manage contract research organizations (CRO) and external chemistry partners across the globe. Oversee structure-activity relationship (SAR) studies to enhance potency, selectivity, and drug-like properties of candidate molecules. Lead efforts to improve pharmacokinetic, pharmacodynamic, and toxicological profiles of compounds in collaboration with ADMET and DMPK teams. Serve as functional expert in due diligences for assets in-licensing and discovery partnerships. Lead publication efforts in high-impact scientific journals. Relevant experience in pharma/biotech drug discovery is highly preferred; experience with computational design or AI/ML is preferred. PhD with management experience is preferred. Minimum Education and Experience
Bachelor\'s degree in a relevant scientific area is required. PhD is preferred. Experience Requirements
Fifteen (15) years of relevant work experience required with a Bachelor\'s degree. Thirteen (13) years of relevant work experience required with a Master\'s degree. Ten (10) years of relevant work experience required with a PhD. Compensation and Benefits
We offer a competitive compensation range and benefits package. A reasonable estimate of the current salary range is $138,320 - $262,080 per year for the role of Principal Scientist in Chemical Induced Proximity. This is an estimate and final offers consider factors such as skill sets, experience, training, and organizational needs. We also provide comprehensive benefits including medical, dental, vision, retirement, wellness programs, time-off, and educational benefits. Benefits
Your health and well-being are important to us. St. Jude provides high-quality benefits choices and coverage for employees and dependents. View all benefits including Medical & Prescription Drug Plans, Dental, Vision, Financial Security, Retirement, Living Well – Employee Wellness Program, Time Off Programs, Educational Benefits, Family Friendly Benefits, and Benefits Unique to St. Jude. About Memphis
Memphis offers big-city amenities with a small-town feel. Our region has a lower cost of living than the national average, no state personal income tax on wages, and a shorter average commute. Learn how you can “Have More in Memphis.” Equal Opportunity and Hiring
St. Jude is an Equal Opportunity Employer. No Search Firms. St. Jude does not accept unsolicited assistance from search firms for employment opportunities. Resumes submitted by search firms without a valid written agreement will not be paid a fee.
#J-18808-Ljbffr