Sr Scientist, Analytical Ops

* Support late-stage assay development by performing mass spectrometry to characterize molecules, degradation pathways, and define critical quality attributes in a phase-appropriate context.* Contribute to analytical method development and qualification for protein characterization.* Develop innovative assays to gain competitive advantages over standard industry practices.* Support comparability and stability studies using mass spectrometry.* Operate, maintain, and troubleshoot Waters, Sciex, Bruker QTOFs, and Thermo Orbitrap mass spectrometers.* Solve complex problems requiring evaluation of intangible variables using logic, ingenuity, and creativity.* Collaborate with junior and senior team members to advance state-of-the-art characterization techniques.* Represent the Structure Characterization group in cross-functional project teams.* Participate in technology transfer of assays to QC and external CRO/CMOs.* Coordinate analysis of in-process and product-related impurities for process comparability studies.* Conduct scientific research to support drug candidate development and marketed drug research.* Advise project teams on experiment planning and execution, considering economic, regulatory, and safety factors.* Present results, interpret data, and draw conclusions from experimental findings.* Stay current with scientific literature and apply relevant knowledge to projects.* Represent the company at national and international conferences.* BS degree with at least 8 years of industry experience OR MS degree with at least 6 years of industry experience.* Strong knowledge of mass spectrometry, experimental design, and assay development.* Demonstrated ability to lead in a cross-functional environment and mentor junior team members.* Ability to work independently with minimal supervision.* Excellent verbal, technical writing, and interpersonal communication skills.* Proficient in Microsoft Office applications.* PhD in Chemistry or related discipline with at least 2 years of industry experience* Familiarity with techniques such as:

+ Peptide mapping by LC-MS/MS

+ Intact mass analysis

+ MS/MS for protein and carbohydrate structural elucidation/quantification

+ Kinetic analyses

+ Ultra-performance chromatography

+ Proteolytic/chemical processing* Knowledge of ICH guidelines and GMP.* Expertise in mass spectrometry analysis software (Protein Metrics, Thermo BioPharma Finder, Skyline).* Experience with data analysis and visualization tools (Python, R, JMP, Spotfire).* Strong organizational and planning skills.* Ability to work effectively in a matrixed environment and communicate assay results and issues clearly. #J-18808-Ljbffr