WuXi Biologics
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Scientist - Ex Vivo & 3D Model Assays
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WuXi Biologics Join to apply for the
Scientist - Ex Vivo & 3D Model Assays
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WuXi Biologics Get AI-powered advice on this job and more exclusive features. Job Title: Scientist – Ex Vivo & 3D Model Assays
Location: Natick, MA
Department: Integrated Discovery Unit
Position Type: Full-Time
Job Summary:
We are seeking a highly motivated Scientist with hands-on expertise in ex vivo immune assays, 3D spheroid, and organoid-based platforms to support our preclinical drug discovery efforts. The successful candidate will have a PhD with 1-2 yrs or Master’s degree with 3–4 years of relevant industry experience and will play a key role in evaluating the biological activity and mechanism of novel therapeutic candidates across oncology, autoimmune, and inflammatory disease areas.
This role is ideal for a scientist passionate about translating complex biology into meaningful data using patient-relevant assay systems.
Key Responsibilities:
Design, execute, and analyze ex vivo assays using human PBMCs, tumor digests, or tissue-derived immune cells. Develop and implement 3D spheroid and organoid-based co-culture systems, including tumor-immune or stroma-immune models. Perform high-content immunophenotyping and functional readouts using multi-color flow cytometry, cytokine profiling (MSD, ELISA, Luminex), and live-cell imaging. Support pharmacodynamic, MOA, and efficacy studies for biologics, TCEs, and other immunomodulatory agents. Work with human biospecimens (e.g., tumor tissue, blood, ascites) and maintain compliance with biosafety and sample handling protocols. Maintain detailed records, present findings at team meetings, and contribute to internal documentation and publications.
Qualifications:
PhD in Immunology, Cell Biology, Pharmacology, or a related field with 1–2 years of hands-on industry experience, or a Master’s degree with 3–4 years of relevant experience in a biotechnology or pharmaceutical setting. Proven expertise in ex vivo immune cell assays, primary cell culture, and immune cell functional analysis. Experience with 3D cell culture systems such as tumor spheroids, organoids, or co-culture models. Strong skills in flow cytometry (data acquisition and analysis), cytokine assays, and viability/proliferation platforms. Familiarity with handling human tissue samples and BSL-2 laboratory practices. Excellent organizational skills, attention to detail, and the ability to independently troubleshoot and optimize assays. Strong team player with effective communication and presentation skills.
Preferred Qualifications:
Experience applying 3D culture platforms to immune-oncology, autoimmune disease, or ither disease area. Proficiency in flow cytometry software (e.g., FlowJo), imaging platforms (e.g., Incucyte), and analysis tools (e.g., GraphPad Prism). Knowledge of T cell biology, myeloid interactions, or tumor microenvironment. Familiarity with antibody-based therapeutic formats, including T cell engagers, ADCs or bispecifics.
The Anticipated pay range for position is $60,000-$100,0000
The job description does not intend to list all the duties and responsibilities assigned to this position. Employee holding this position would be required to perform other job-related duties/responsibilities based on their expertise and company business needs.
WuXi Biologics is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability Seniority level
Seniority level Entry level Employment type
Employment type Full-time Job function
Job function Research, Analyst, and Information Technology Industries Pharmaceutical Manufacturing Referrals increase your chances of interviewing at WuXi Biologics by 2x Get notified about new Scientist jobs in
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Scientist - Ex Vivo & 3D Model Assays
role at
WuXi Biologics Join to apply for the
Scientist - Ex Vivo & 3D Model Assays
role at
WuXi Biologics Get AI-powered advice on this job and more exclusive features. Job Title: Scientist – Ex Vivo & 3D Model Assays
Location: Natick, MA
Department: Integrated Discovery Unit
Position Type: Full-Time
Job Summary:
We are seeking a highly motivated Scientist with hands-on expertise in ex vivo immune assays, 3D spheroid, and organoid-based platforms to support our preclinical drug discovery efforts. The successful candidate will have a PhD with 1-2 yrs or Master’s degree with 3–4 years of relevant industry experience and will play a key role in evaluating the biological activity and mechanism of novel therapeutic candidates across oncology, autoimmune, and inflammatory disease areas.
This role is ideal for a scientist passionate about translating complex biology into meaningful data using patient-relevant assay systems.
Key Responsibilities:
Design, execute, and analyze ex vivo assays using human PBMCs, tumor digests, or tissue-derived immune cells. Develop and implement 3D spheroid and organoid-based co-culture systems, including tumor-immune or stroma-immune models. Perform high-content immunophenotyping and functional readouts using multi-color flow cytometry, cytokine profiling (MSD, ELISA, Luminex), and live-cell imaging. Support pharmacodynamic, MOA, and efficacy studies for biologics, TCEs, and other immunomodulatory agents. Work with human biospecimens (e.g., tumor tissue, blood, ascites) and maintain compliance with biosafety and sample handling protocols. Maintain detailed records, present findings at team meetings, and contribute to internal documentation and publications.
Qualifications:
PhD in Immunology, Cell Biology, Pharmacology, or a related field with 1–2 years of hands-on industry experience, or a Master’s degree with 3–4 years of relevant experience in a biotechnology or pharmaceutical setting. Proven expertise in ex vivo immune cell assays, primary cell culture, and immune cell functional analysis. Experience with 3D cell culture systems such as tumor spheroids, organoids, or co-culture models. Strong skills in flow cytometry (data acquisition and analysis), cytokine assays, and viability/proliferation platforms. Familiarity with handling human tissue samples and BSL-2 laboratory practices. Excellent organizational skills, attention to detail, and the ability to independently troubleshoot and optimize assays. Strong team player with effective communication and presentation skills.
Preferred Qualifications:
Experience applying 3D culture platforms to immune-oncology, autoimmune disease, or ither disease area. Proficiency in flow cytometry software (e.g., FlowJo), imaging platforms (e.g., Incucyte), and analysis tools (e.g., GraphPad Prism). Knowledge of T cell biology, myeloid interactions, or tumor microenvironment. Familiarity with antibody-based therapeutic formats, including T cell engagers, ADCs or bispecifics.
The Anticipated pay range for position is $60,000-$100,0000
The job description does not intend to list all the duties and responsibilities assigned to this position. Employee holding this position would be required to perform other job-related duties/responsibilities based on their expertise and company business needs.
WuXi Biologics is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability Seniority level
Seniority level Entry level Employment type
Employment type Full-time Job function
Job function Research, Analyst, and Information Technology Industries Pharmaceutical Manufacturing Referrals increase your chances of interviewing at WuXi Biologics by 2x Get notified about new Scientist jobs in
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We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
#J-18808-Ljbffr