University of Washington
This position focuses on epigenetic engineering, gene regulation, and stem cell biology, specifically the development and application of AI-designed epigenetic protein binders (EpiBinders) and CRISPR-dCas9-based systems to modulate gene expression in regenerative medicine, immunotherapy, and disease modeling.
The position supports translational research projects aimed at:
Enhancing pancreatic islet cell differentiation and function for diabetes therapies
Reversing muscle aging and promoting regeneration in sarcopenia
Reprogramming ductal or hepatic cells for cell replacement therapies
Developing next-generation epigenetic tools to improve therapeutic precision and reduce off-target effects.
Major duties and responsibilities include:
Design and execution of epigenetic editing experiments using CRISPR-dCas9 or EpiBinders
Computational and experimental development of AI-guided mini-proteins for chromatin modulation
Mentoring and supervising trainees and junior scientists
Project management, experimental planning, data analysis, and manuscript preparations
Grant writing, IP strategy, and stakeholder engagement
Collaborative coordination with internal and external research teams
Minimum requirements include a Master's degree in Molecular Biology and four years of experience with epigenetic engineering, gene regulation, and stem cell biology, or an equivalent combination of education and experience.
Additional requirements include:
Advanced knowledge of epigenetic regulation, including chromatin remodeling, histone modifications, and DNA methylation/demethylation pathways
Expertise in CRISPR-based epigenetic editing platforms
Proficiency in designing, generating, and testing AI-guided epigenetic mini-proteins for targeted gene regulation
Experience with mammalian cell culture and technical skills in molecular biology techniques
Ability to develop, execute, and interpret high-throughput screening experiments
Strong data analysis skills and excellent scientific communication skills
Desired qualifications include expertise in therapeutic development, experience in epigenome engineering, and knowledge of lipid nanoparticle formulation and delivery strategies.
The University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, national origin, age, protected veteran or disabled status, or genetic information.
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