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University of Washington

Research Scientist/Engr 4

University of Washington, Seattle, Washington, us, 98127

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This position focuses on epigenetic engineering, gene regulation, and stem cell biology, specifically the development and application of AI-designed epigenetic protein binders (EpiBinders) and CRISPR-dCas9-based systems to modulate gene expression in regenerative medicine, immunotherapy, and disease modeling. The position supports translational research projects aimed at: Enhancing pancreatic islet cell differentiation and function for diabetes therapies Reversing muscle aging and promoting regeneration in sarcopenia Reprogramming ductal or hepatic cells for cell replacement therapies Developing next-generation epigenetic tools to improve therapeutic precision and reduce off-target effects. Major duties and responsibilities include: Design and execution of epigenetic editing experiments using CRISPR-dCas9 or EpiBinders Computational and experimental development of AI-guided mini-proteins for chromatin modulation Mentoring and supervising trainees and junior scientists Project management, experimental planning, data analysis, and manuscript preparations Grant writing, IP strategy, and stakeholder engagement Collaborative coordination with internal and external research teams Minimum requirements include a Master's degree in Molecular Biology and four years of experience with epigenetic engineering, gene regulation, and stem cell biology, or an equivalent combination of education and experience. Additional requirements include: Advanced knowledge of epigenetic regulation, including chromatin remodeling, histone modifications, and DNA methylation/demethylation pathways Expertise in CRISPR-based epigenetic editing platforms Proficiency in designing, generating, and testing AI-guided epigenetic mini-proteins for targeted gene regulation Experience with mammalian cell culture and technical skills in molecular biology techniques Ability to develop, execute, and interpret high-throughput screening experiments Strong data analysis skills and excellent scientific communication skills Desired qualifications include expertise in therapeutic development, experience in epigenome engineering, and knowledge of lipid nanoparticle formulation and delivery strategies. The University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, national origin, age, protected veteran or disabled status, or genetic information.

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