Amgen
Senior Scientist - Targeted Protein Degradation
Amgen, Thousand Oaks, California, United States, 91362
Overview
Senior Scientist - Targeted Protein Degradation at Amgen. The Targeted Protein Degradation function within Amgen’s Induced Proximity Platform (IPP) is driving innovation in molecular glue degraders to induce selective degradation of disease-relevant proteins. This role supports molecular glue discovery and the establishment and execution of phenotypic-based screening platforms to advance Amgen’s strategy in induced proximity technologies.
This position offers the opportunity to lead from the bench while shaping platform capabilities that enable broad discovery efforts, collaborating across IPP and partner functions to broaden understanding of emerging IPP technologies and their practical applications.
What You Will Do
Design, establish, and implement phenotypic-based screening platforms to enable discovery of novel induced proximity mechanisms.
Develop and optimize assays that capture cellular context, functional outcomes, and disease relevance.
Work with automation and high-throughput screening teams to scale phenotypic platforms for broader application across IPP.
Integrate advanced imaging, omics, and data science approaches to extract actionable biological insights from phenotypic screens.
Apply diverse experimental approaches, including biochemical, biophysical, and cell biology techniques, to understand degrader mechanisms of action.
Partner with cross-functional teams across IPP and external collaborators to broaden the scope of induced proximity drug discovery.
Share insights through internal presentations, publications, and external conferences.
Provide scientific mentorship to junior scientists and contribute to fostering an environment of curiosity and innovation.
What We Expect Of You We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an innovator with these qualifications.
Basic Qualifications
Doctorate degree (PhD) OR PharmD OR MD (and relevant post-doc where applicable)
Or Master’s degree and 3 years of directly related experience
Or Bachelor’s degree and 5 years of directly related experience
Preferred Qualifications
PhD in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field, with postdoctoral training or equivalent industry experience.
2+ years of relevant industry experience (biotechnology or pharmaceutical research).
Demonstrated expertise in targeted protein degradation, molecular glue biology, or proximity-based drug discovery.
Hands-on experience developing and executing cellular assays or phenotypic screening approaches.
Track record of assay development for high-content or high-throughput phenotypic screening, including use of automation and advanced imaging technologies.
Proficiency in cellular and molecular biology techniques, such as CRISPR-based perturbations, proteomics, or transcriptomics applied to phenotypic readouts.
Experience applying systems biology and data integration approaches to interpret complex phenotypic datasets.
Strong scientific creativity with a record of publications, patents, or conference presentations in relevant fields.
Excellent interpersonal and communication skills; ability to work collaboratively in a matrixed research environment.
What you can expect from us We support your professional and personal growth and well-being through competitive benefits and a collaborative culture. Details on compensation, benefits, and rewards are provided during the interview process.
Equal Opportunity and Accommodations Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will provide reasonable accommodation to participate in the job application or interview process and to perform essential job functions. Please contact us to request accommodation.
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This position offers the opportunity to lead from the bench while shaping platform capabilities that enable broad discovery efforts, collaborating across IPP and partner functions to broaden understanding of emerging IPP technologies and their practical applications.
What You Will Do
Design, establish, and implement phenotypic-based screening platforms to enable discovery of novel induced proximity mechanisms.
Develop and optimize assays that capture cellular context, functional outcomes, and disease relevance.
Work with automation and high-throughput screening teams to scale phenotypic platforms for broader application across IPP.
Integrate advanced imaging, omics, and data science approaches to extract actionable biological insights from phenotypic screens.
Apply diverse experimental approaches, including biochemical, biophysical, and cell biology techniques, to understand degrader mechanisms of action.
Partner with cross-functional teams across IPP and external collaborators to broaden the scope of induced proximity drug discovery.
Share insights through internal presentations, publications, and external conferences.
Provide scientific mentorship to junior scientists and contribute to fostering an environment of curiosity and innovation.
What We Expect Of You We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an innovator with these qualifications.
Basic Qualifications
Doctorate degree (PhD) OR PharmD OR MD (and relevant post-doc where applicable)
Or Master’s degree and 3 years of directly related experience
Or Bachelor’s degree and 5 years of directly related experience
Preferred Qualifications
PhD in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field, with postdoctoral training or equivalent industry experience.
2+ years of relevant industry experience (biotechnology or pharmaceutical research).
Demonstrated expertise in targeted protein degradation, molecular glue biology, or proximity-based drug discovery.
Hands-on experience developing and executing cellular assays or phenotypic screening approaches.
Track record of assay development for high-content or high-throughput phenotypic screening, including use of automation and advanced imaging technologies.
Proficiency in cellular and molecular biology techniques, such as CRISPR-based perturbations, proteomics, or transcriptomics applied to phenotypic readouts.
Experience applying systems biology and data integration approaches to interpret complex phenotypic datasets.
Strong scientific creativity with a record of publications, patents, or conference presentations in relevant fields.
Excellent interpersonal and communication skills; ability to work collaboratively in a matrixed research environment.
What you can expect from us We support your professional and personal growth and well-being through competitive benefits and a collaborative culture. Details on compensation, benefits, and rewards are provided during the interview process.
Equal Opportunity and Accommodations Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will provide reasonable accommodation to participate in the job application or interview process and to perform essential job functions. Please contact us to request accommodation.
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