Amgen
Scientist - Targeted Protein Degradation
Amgen, Thousand Oaks, California, United States, 91362
Overview
Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas – Oncology, Inflammation, General Medicine, and Rare Disease – we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lie within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Scientist - Targeted Protein Degradation
What You Will Do
Let’s do this. Let’s change the world. Amgen’s Induced Proximity Platform (IPP) organization is committed to pushing the boundaries of drug discovery by harnessing proximity biology to address difficult and previously undruggable targets. The IPP team develops novel therapeutic modalities, including Molecular Glue Degraders and other Induced Proximity strategies, with applications across Oncology, Cardiometabolic Disorders, Inflammation, and Rare Diseases. Our scientists are part of a collaborative, multidisciplinary environment where biology, chemistry, and technology innovation converge to deliver transformative medicines for patients. The Targeted Protein Degradation function within IPP is seeking a motivated Scientist to play a key role in building phenotypic-based screening platforms that will enable the identification of Molecular Glues for high-value targets. In this vital role you will contribute directly to cutting-edge drug discovery programs, while developing valuable expertise at the intersection of molecular biology, cell biology, and chemical biology. Key Responsibilities
Execute experiments to identify, characterize, and optimize molecular glue degraders for therapeutic targets. Perform biochemical and cellular assays to investigate degrader activity and mechanisms of action. Collaborate with cross-functional partners in medicinal chemistry, biology, and data science to advance discovery programs. Assist in the design and implementation of phenotypic-based screening platforms for induced proximity drug discovery. Develop and validate cell-based assays that capture functional outcomes relevant to disease biology (HiBiT, NanoBiT, Cell viability assays). Support screening campaigns using high-throughput or high-content approaches, in partnership with automation and data teams. Work closely with colleagues across IPP to share results and integrate findings into broader discovery efforts. Present research progress in team meetings and contribute to technical reports and publications. Participate in a collaborative, fast-paced research culture that values creativity, rigor, and teamwork. What We Expect Of You
We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an innovator with these qualifications. Basic Qualifications
Doctorate degree Or Master’s degree and 2 years of directly related experience Or Bachelor’s degree and 4 years of directly related experience Preferred Qualifications
Master’s degree in Cell Biology, Molecular Biology, Chemical Biology, Biochemistry, Pharmacology, or a related field. 1+ years of relevant industry experience (biotechnology or pharmaceutical research). Hands-on experience with cellular and molecular biology techniques (e.g., cell culture, transfection, Western blotting, flow cytometry, ELISA, or related methods). Experience in cell-based assay development and/or phenotypic screening approaches. Familiarity with protein degradation or induced proximity biology. Exposure to automation or high-throughput technologies. Strong data analysis skills, with the ability to interpret, and efficiently report, experimental results and troubleshoot assays. Effective communication skills, both written and verbal, with the ability to work in a team-oriented environment. What You Can Expect Of Us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program Stock-based long-term incentives Award-winning time-off plans Flexible work models, including remote and hybrid work arrangements, where possible Apply now and make a lasting impact with the Amgen team. Equal Opportunity Employer information and accommodation requests are available at careers.amgen.com. In any materials you submit, you may redact or remove age-identifying information. We will not penalize you for doing so.
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Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas – Oncology, Inflammation, General Medicine, and Rare Disease – we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lie within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Scientist - Targeted Protein Degradation
What You Will Do
Let’s do this. Let’s change the world. Amgen’s Induced Proximity Platform (IPP) organization is committed to pushing the boundaries of drug discovery by harnessing proximity biology to address difficult and previously undruggable targets. The IPP team develops novel therapeutic modalities, including Molecular Glue Degraders and other Induced Proximity strategies, with applications across Oncology, Cardiometabolic Disorders, Inflammation, and Rare Diseases. Our scientists are part of a collaborative, multidisciplinary environment where biology, chemistry, and technology innovation converge to deliver transformative medicines for patients. The Targeted Protein Degradation function within IPP is seeking a motivated Scientist to play a key role in building phenotypic-based screening platforms that will enable the identification of Molecular Glues for high-value targets. In this vital role you will contribute directly to cutting-edge drug discovery programs, while developing valuable expertise at the intersection of molecular biology, cell biology, and chemical biology. Key Responsibilities
Execute experiments to identify, characterize, and optimize molecular glue degraders for therapeutic targets. Perform biochemical and cellular assays to investigate degrader activity and mechanisms of action. Collaborate with cross-functional partners in medicinal chemistry, biology, and data science to advance discovery programs. Assist in the design and implementation of phenotypic-based screening platforms for induced proximity drug discovery. Develop and validate cell-based assays that capture functional outcomes relevant to disease biology (HiBiT, NanoBiT, Cell viability assays). Support screening campaigns using high-throughput or high-content approaches, in partnership with automation and data teams. Work closely with colleagues across IPP to share results and integrate findings into broader discovery efforts. Present research progress in team meetings and contribute to technical reports and publications. Participate in a collaborative, fast-paced research culture that values creativity, rigor, and teamwork. What We Expect Of You
We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an innovator with these qualifications. Basic Qualifications
Doctorate degree Or Master’s degree and 2 years of directly related experience Or Bachelor’s degree and 4 years of directly related experience Preferred Qualifications
Master’s degree in Cell Biology, Molecular Biology, Chemical Biology, Biochemistry, Pharmacology, or a related field. 1+ years of relevant industry experience (biotechnology or pharmaceutical research). Hands-on experience with cellular and molecular biology techniques (e.g., cell culture, transfection, Western blotting, flow cytometry, ELISA, or related methods). Experience in cell-based assay development and/or phenotypic screening approaches. Familiarity with protein degradation or induced proximity biology. Exposure to automation or high-throughput technologies. Strong data analysis skills, with the ability to interpret, and efficiently report, experimental results and troubleshoot assays. Effective communication skills, both written and verbal, with the ability to work in a team-oriented environment. What You Can Expect Of Us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program Stock-based long-term incentives Award-winning time-off plans Flexible work models, including remote and hybrid work arrangements, where possible Apply now and make a lasting impact with the Amgen team. Equal Opportunity Employer information and accommodation requests are available at careers.amgen.com. In any materials you submit, you may redact or remove age-identifying information. We will not penalize you for doing so.
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