BioSpace
Scientist - Targeted Protein Degradation
BioSpace, Thousand Oaks, California, United States, 91362
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Scientist - Targeted Protein Degradation
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Amgen’s Induced Proximity Platform (IPP) organization seeks a Scientist to build phenotypic-based screening platforms to identify Molecular Glue degraders for high-value targets within a collaborative, multidisciplinary environment integrating biology, chemistry, and technology to deliver transformative medicines. What You Will Do
Execute experiments to identify, characterize, and optimize molecular glue degraders for therapeutic targets. Perform biochemical and cellular assays to investigate degrader activity and mechanisms of action. Collaborate with cross-functional partners in medicinal chemistry, biology, and data science to advance discovery programs. Assist in the design and implementation of phenotypic-based screening platforms for induced proximity drug discovery. Develop and validate cell-based assays that capture functional outcomes relevant to disease biology (HiBiT, NanoBiT, Cell viability assays). Support screening campaigns using high-throughput or high-content approaches, in partnership with automation and data teams. Work closely with colleagues across IPP to share results and integrate findings into broader discovery efforts. Present research progress in team meetings and contribute to technical reports and publications. Participate in a collaborative, fast-paced research culture that values creativity, rigor, and teamwork. What We Expect of You
We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an innovator with these qualifications. Basic Qualifications
Doctorate degree Or Masters degree and 2 years of directly related experience Or Bachelors degree and 4 years of directly related experience Preferred Qualifications
Masters degree in Cell Biology, Molecular Biology, Chemical Biology, Biochemistry, Pharmacology, or a related field. 1+ years of relevant industry experience (biotechnology or pharmaceutical research). Hands-on experience with cellular and molecular biology techniques (e.g., cell culture, transfection, Western blotting, flow cytometry, ELISA, or related methods). Experience in cell-based assay development and/or phenotypic screening approaches. Familiarity with protein degradation or induced proximity biology. Exposure to automation or high-throughput technologies. Strong data analysis skills, with the ability to interpret and report experimental results and troubleshoot assays. Effective communication skills, both written and verbal, with the ability to work in a team-oriented environment. What You Can Expect From Us
We support your professional and personal growth and well-being through a competitive benefits package and collaborative culture. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on skills, experience, and qualifications. In addition to base salary, Amgen offers a Total Rewards Plan including health and welfare plans, retirement savings, work-life balance, and career development opportunities. A comprehensive benefits package with medical, dental, vision, life and disability insurance, and flexible spending accounts. Stock-based long-term incentives and discretionary bonuses. Award-winning time-off plans and flexible work models where possible. Apply now and make a lasting impact with the Amgen team. For more information, careers.amgen.com Equal Opportunity
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. Reasonable accommodations are available to applicants with disabilities. Please contact us to request accommodation. Job Details
Seniority level: Entry level Employment type: Full-time Job function: Research, Analyst, and Information Technology Industries: Internet News
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Scientist - Targeted Protein Degradation
role at
BioSpace Get AI-powered advice on this job and more exclusive features. Overview
Amgen’s Induced Proximity Platform (IPP) organization seeks a Scientist to build phenotypic-based screening platforms to identify Molecular Glue degraders for high-value targets within a collaborative, multidisciplinary environment integrating biology, chemistry, and technology to deliver transformative medicines. What You Will Do
Execute experiments to identify, characterize, and optimize molecular glue degraders for therapeutic targets. Perform biochemical and cellular assays to investigate degrader activity and mechanisms of action. Collaborate with cross-functional partners in medicinal chemistry, biology, and data science to advance discovery programs. Assist in the design and implementation of phenotypic-based screening platforms for induced proximity drug discovery. Develop and validate cell-based assays that capture functional outcomes relevant to disease biology (HiBiT, NanoBiT, Cell viability assays). Support screening campaigns using high-throughput or high-content approaches, in partnership with automation and data teams. Work closely with colleagues across IPP to share results and integrate findings into broader discovery efforts. Present research progress in team meetings and contribute to technical reports and publications. Participate in a collaborative, fast-paced research culture that values creativity, rigor, and teamwork. What We Expect of You
We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an innovator with these qualifications. Basic Qualifications
Doctorate degree Or Masters degree and 2 years of directly related experience Or Bachelors degree and 4 years of directly related experience Preferred Qualifications
Masters degree in Cell Biology, Molecular Biology, Chemical Biology, Biochemistry, Pharmacology, or a related field. 1+ years of relevant industry experience (biotechnology or pharmaceutical research). Hands-on experience with cellular and molecular biology techniques (e.g., cell culture, transfection, Western blotting, flow cytometry, ELISA, or related methods). Experience in cell-based assay development and/or phenotypic screening approaches. Familiarity with protein degradation or induced proximity biology. Exposure to automation or high-throughput technologies. Strong data analysis skills, with the ability to interpret and report experimental results and troubleshoot assays. Effective communication skills, both written and verbal, with the ability to work in a team-oriented environment. What You Can Expect From Us
We support your professional and personal growth and well-being through a competitive benefits package and collaborative culture. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on skills, experience, and qualifications. In addition to base salary, Amgen offers a Total Rewards Plan including health and welfare plans, retirement savings, work-life balance, and career development opportunities. A comprehensive benefits package with medical, dental, vision, life and disability insurance, and flexible spending accounts. Stock-based long-term incentives and discretionary bonuses. Award-winning time-off plans and flexible work models where possible. Apply now and make a lasting impact with the Amgen team. For more information, careers.amgen.com Equal Opportunity
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. Reasonable accommodations are available to applicants with disabilities. Please contact us to request accommodation. Job Details
Seniority level: Entry level Employment type: Full-time Job function: Research, Analyst, and Information Technology Industries: Internet News
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