BioSpace
Senior Scientist/Principal Scientist, Proteomics, Discovery Technologies
BioSpace, New York, New York, us, 10261
Senior Scientist/Principal Scientist, Proteomics, Discovery Technologies
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. Overview Lilly serves an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Position Summary The Scientist in the Multiomics Group, within Discovery Technologies, will be joining a dynamic group focused on executing experiments on the cutting edge of pharmaceutical sciences. This scientist will work closely with the Molecular Characterization and Discovery Proteomics teams to design studies, execute analyses, and interpret data to support the various research programs for identified targets. The successful candidate is expected to demonstrate expertise with various innovative, high throughput, high content molecular platforms profiling protein, DNA and RNA along with basic molecular biology techniques. Responsibilities
Interact and collaborate with various discovery technologies functional teams to develop and implement high content and high throughput proteomic platforms Design and execute studies using protein platforms like Olink, Somalogic, Milliplex, Quanterix, etc for biomarker discovery and mechanistic investigations Develop scalable workflows for multiplex protein profiling across diverse sample types (plasma, serum, CSF, tissue lysates) Stay current on cutting edge technologies and work collaboratively with proteomics team to validate and implement new proteomics platform as needed Install, maintain, operate, and optimize platform instrumentation while ensuring peak performance and data quality Innovate sample preparation protocols tailored to platform-specific chemistry and biological matrix requirements Lead data analysis initiatives using advanced statistical methods, platform-specific tools, and machine learning approaches Drive cross-functional collaboration with cell biology, immunology, computational biology, and clinical research teams Generate actionable insights through comprehensive technical reporting and data visualization Champion scientific excellence by staying at the forefront of proteomics technology advances and ultra-sensitive detection methods Maintain rigorous standards for laboratory safety, regulatory compliance, and data integrity Establish protocol QC methods and standards to ensure quality data and analyses from a variety of high throughput, high content genomic, transcriptomic, and proteomic platforms Responsible for establishing and updating lab SOPs and training lab scientists as needed Work with the entire molecular characterization team to ensure all instrumentation is properly maintained and calibrated Proper documentation and archiving of data and analyses Basic Requirements
Master's degree (with 2-3 years’ experience) or Bachelor's degree (with 5+ years’) in Biochemistry, Proteomics, Immunology, Cell Biology, or related field Hands-on expertise with Olink OR Somalogic platforms, including end-to-end study management from design through analysis is strongly preferred Broad experience with multiple protein analysis platforms, including assay design and development Experience with high content, high throughput laboratory workflows with emphasis on quality and efficiency Demonstrated experience in working collaboratively across various scientific disciplines to meet project goals and timelines Proven track record in interpreting complex biological data and translating findings into actionable research directions Exceptional analytical and problem-solving capabilities with meticulous attention to experimental detail Additional Preferences
Proficiency in R or Python for large scale omics data analysis and visualization Hands-on experience and thorough understanding of the mass spectrometry-based proteomic workflows Demonstrated experience developing and validating complementary immunoassays (ELISA, MSD, Jess systems) Expertise in pathway analysis and network biology approaches for systems-level insights Knowledge of spatial proteomics methods and advanced tissue imaging techniques Machine learning experience for biomarker signature development and validation Strong publication record in peer-reviewed journals featuring high-plex proteomics applications Experience with clinical sample management and biobanking best practices Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form for further assistance. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. Overview Lilly serves an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Position Summary The Scientist in the Multiomics Group, within Discovery Technologies, will be joining a dynamic group focused on executing experiments on the cutting edge of pharmaceutical sciences. This scientist will work closely with the Molecular Characterization and Discovery Proteomics teams to design studies, execute analyses, and interpret data to support the various research programs for identified targets. The successful candidate is expected to demonstrate expertise with various innovative, high throughput, high content molecular platforms profiling protein, DNA and RNA along with basic molecular biology techniques. Responsibilities
Interact and collaborate with various discovery technologies functional teams to develop and implement high content and high throughput proteomic platforms Design and execute studies using protein platforms like Olink, Somalogic, Milliplex, Quanterix, etc for biomarker discovery and mechanistic investigations Develop scalable workflows for multiplex protein profiling across diverse sample types (plasma, serum, CSF, tissue lysates) Stay current on cutting edge technologies and work collaboratively with proteomics team to validate and implement new proteomics platform as needed Install, maintain, operate, and optimize platform instrumentation while ensuring peak performance and data quality Innovate sample preparation protocols tailored to platform-specific chemistry and biological matrix requirements Lead data analysis initiatives using advanced statistical methods, platform-specific tools, and machine learning approaches Drive cross-functional collaboration with cell biology, immunology, computational biology, and clinical research teams Generate actionable insights through comprehensive technical reporting and data visualization Champion scientific excellence by staying at the forefront of proteomics technology advances and ultra-sensitive detection methods Maintain rigorous standards for laboratory safety, regulatory compliance, and data integrity Establish protocol QC methods and standards to ensure quality data and analyses from a variety of high throughput, high content genomic, transcriptomic, and proteomic platforms Responsible for establishing and updating lab SOPs and training lab scientists as needed Work with the entire molecular characterization team to ensure all instrumentation is properly maintained and calibrated Proper documentation and archiving of data and analyses Basic Requirements
Master's degree (with 2-3 years’ experience) or Bachelor's degree (with 5+ years’) in Biochemistry, Proteomics, Immunology, Cell Biology, or related field Hands-on expertise with Olink OR Somalogic platforms, including end-to-end study management from design through analysis is strongly preferred Broad experience with multiple protein analysis platforms, including assay design and development Experience with high content, high throughput laboratory workflows with emphasis on quality and efficiency Demonstrated experience in working collaboratively across various scientific disciplines to meet project goals and timelines Proven track record in interpreting complex biological data and translating findings into actionable research directions Exceptional analytical and problem-solving capabilities with meticulous attention to experimental detail Additional Preferences
Proficiency in R or Python for large scale omics data analysis and visualization Hands-on experience and thorough understanding of the mass spectrometry-based proteomic workflows Demonstrated experience developing and validating complementary immunoassays (ELISA, MSD, Jess systems) Expertise in pathway analysis and network biology approaches for systems-level insights Knowledge of spatial proteomics methods and advanced tissue imaging techniques Machine learning experience for biomarker signature development and validation Strong publication record in peer-reviewed journals featuring high-plex proteomics applications Experience with clinical sample management and biobanking best practices Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form for further assistance. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
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