Pixium Vision S.A.
Overview
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Research Associate, In Vitro
role at
Pixium Vision S.A. Science is a clinical stage, vertically integrated technology company focused on solving some of neuroscience's hardest questions and most serious unmet medical needs. We work to restore quality of life to those with debilitating conditions for which there are no treatment options, creating devices aimed at restoring vision, cognition, and mobility to patients who have lost it. To support progress across our industry, we provide state-of-the-art components and vertically integrated infrastructure for others to build on via Science Foundry. Join our team of scientists and engineers as we develop next-generation cell and gene therapies for brain-computer interfaces and optogenetic vision restoration. You'll contribute directly to pioneering research with the potential to restore sight to the blind and create revolutionary neural interfaces. This is a perfect opportunity for a scientist to apply their expertise in neuronal differentiation in a fast-paced research environment focused on therapeutic applications.
Responsibilities Execute highly reproducible iPSC differentiation protocols to generate defined neuronal subtypes, with particular expertise in cortical neurons, inhibitory interneurons, and dopaminergic neurons
Develop, optimize, and rigorously adhere to detailed Standard Operating Procedures (SOPs) for all neuronal differentiation workflows
Perform single-cell RNA sequencing (sc-RNAseq) sample preparation, library construction, and quality control analysis
Execute advanced FACS sorting and analysis for neuronal population characterization and purification
Conduct comprehensive immunohistochemistry (IHC) and immunocytochemistry protocols for neuronal marker validation
Implement rigorous quality control assays throughout differentiation timelines, including cell viability, purity, and functional assessments
Maintain detailed documentation and data integrity across all experimental procedures
Perform molecular biology assays including qPCR, digital PCR, and protein quantification methods
Key Qualifications A highly skilled laboratory scientist with 2+ years of specialized experience in iPSC-derived neuronal differentiation
Demonstrated expertise with stem cell differentiation protocols
Experience with single-cell RNA sequencing workflows
Proficiency in FACS operation, analysis, and troubleshooting
Proficiency in immunohistochemistry and fluorescence microscopy
Exceptional attention to detail with a track record of maintaining rigorous experimental standards
Proven ability to develop, document, and consistently follow detailed experimental protocols
Has a methodical approach to laboratory work with zero tolerance for procedural deviations
Preferred Qualifications Experience with electrophysiological characterization of differentiated neurons
Proficiency in confocal microscopy and automated image analysis for neuronal morphology assessment
Knowledge of neuronal subtype-specific markers and functional validation approaches
Experience with organoid development and 3D neuronal culture systems
Strong subject matter expertise in developmental neurobiology, neuronal specification, or neurodegenerative diseases
Demonstrated track record of contributing to SOP development and laboratory standardization efforts
Salary and benefits: Science is required under California law to include a reasonable estimate of the compensation range for this role. The base salary range for this full-time position is
$90,000-$115,000
annually + equity + benefits. Within the range, individual pay is determined by factors including skills, experience, and education. Equity is not included in the base salary numbers.
Benefits Competitive salary and equity
Medical, dental, vision and life insurance
Flexible vacation and company-paid holidays
Healthy meals and snacks provided for non-remote employees
Paid parental, jury duty, bereavement, family care and medical leave
Flexible Spending Account and Dependent Care Flexible Spending Account
Childcare subsidy by Science
401(k)
Science Corporation is an equal opportunity employer. We seek applicants of all backgrounds and identities, and applicants will not be discriminated against based on protected characteristics. We will also consider qualified applicants with criminal histories in a manner consistent with applicable laws.
Apply now
#J-18808-Ljbffr
Join to apply for the
Research Associate, In Vitro
role at
Pixium Vision S.A. Science is a clinical stage, vertically integrated technology company focused on solving some of neuroscience's hardest questions and most serious unmet medical needs. We work to restore quality of life to those with debilitating conditions for which there are no treatment options, creating devices aimed at restoring vision, cognition, and mobility to patients who have lost it. To support progress across our industry, we provide state-of-the-art components and vertically integrated infrastructure for others to build on via Science Foundry. Join our team of scientists and engineers as we develop next-generation cell and gene therapies for brain-computer interfaces and optogenetic vision restoration. You'll contribute directly to pioneering research with the potential to restore sight to the blind and create revolutionary neural interfaces. This is a perfect opportunity for a scientist to apply their expertise in neuronal differentiation in a fast-paced research environment focused on therapeutic applications.
Responsibilities Execute highly reproducible iPSC differentiation protocols to generate defined neuronal subtypes, with particular expertise in cortical neurons, inhibitory interneurons, and dopaminergic neurons
Develop, optimize, and rigorously adhere to detailed Standard Operating Procedures (SOPs) for all neuronal differentiation workflows
Perform single-cell RNA sequencing (sc-RNAseq) sample preparation, library construction, and quality control analysis
Execute advanced FACS sorting and analysis for neuronal population characterization and purification
Conduct comprehensive immunohistochemistry (IHC) and immunocytochemistry protocols for neuronal marker validation
Implement rigorous quality control assays throughout differentiation timelines, including cell viability, purity, and functional assessments
Maintain detailed documentation and data integrity across all experimental procedures
Perform molecular biology assays including qPCR, digital PCR, and protein quantification methods
Key Qualifications A highly skilled laboratory scientist with 2+ years of specialized experience in iPSC-derived neuronal differentiation
Demonstrated expertise with stem cell differentiation protocols
Experience with single-cell RNA sequencing workflows
Proficiency in FACS operation, analysis, and troubleshooting
Proficiency in immunohistochemistry and fluorescence microscopy
Exceptional attention to detail with a track record of maintaining rigorous experimental standards
Proven ability to develop, document, and consistently follow detailed experimental protocols
Has a methodical approach to laboratory work with zero tolerance for procedural deviations
Preferred Qualifications Experience with electrophysiological characterization of differentiated neurons
Proficiency in confocal microscopy and automated image analysis for neuronal morphology assessment
Knowledge of neuronal subtype-specific markers and functional validation approaches
Experience with organoid development and 3D neuronal culture systems
Strong subject matter expertise in developmental neurobiology, neuronal specification, or neurodegenerative diseases
Demonstrated track record of contributing to SOP development and laboratory standardization efforts
Salary and benefits: Science is required under California law to include a reasonable estimate of the compensation range for this role. The base salary range for this full-time position is
$90,000-$115,000
annually + equity + benefits. Within the range, individual pay is determined by factors including skills, experience, and education. Equity is not included in the base salary numbers.
Benefits Competitive salary and equity
Medical, dental, vision and life insurance
Flexible vacation and company-paid holidays
Healthy meals and snacks provided for non-remote employees
Paid parental, jury duty, bereavement, family care and medical leave
Flexible Spending Account and Dependent Care Flexible Spending Account
Childcare subsidy by Science
401(k)
Science Corporation is an equal opportunity employer. We seek applicants of all backgrounds and identities, and applicants will not be discriminated against based on protected characteristics. We will also consider qualified applicants with criminal histories in a manner consistent with applicable laws.
Apply now
#J-18808-Ljbffr