Science Corp
Overview
Science is a clinical stage, vertically integrated technology company focused on solving some of neuroscience's hardest questions and most serious unmet medical needs. We work to restore quality of life to those with debilitating conditions for which there are no treatment options, creating devices aimed at restoring vision, cognition, and mobility to patients who have lost it. To support progress across our industry, we provide state-of-the-art components and vertically integrated infrastructure for others to build on via Science Foundry.
Join our team of scientists and engineers as we develop next-generation cell and gene therapies for brain-computer interfaces and optogenetic vision restoration. You'll contribute directly to pioneering research with the potential to restore sight to the blind and create revolutionary neural interfaces. This is a perfect opportunity for a scientist to apply their expertise in neuronal differentiation in a fast-paced research environment focused on therapeutic applications.
Role responsibilities
Execute highly reproducible iPSC differentiation protocols to generate defined neuronal subtypes, with particular expertise in cortical neurons, inhibitory interneurons, and dopaminergic neurons
Develop, optimize, and rigorously adhere to detailed Standard Operating Procedures (SOPs) for all neuronal differentiation workflows
Perform single-cell RNA sequencing (sc-RNAseq) sample preparation, library construction, and quality control analysis
Execute advanced FACS sorting and analysis for neuronal population characterization and purification
Conduct comprehensive immunohistochemistry (IHC) and immunocytochemistry protocols for neuronal marker validation
Implement rigorous quality control assays throughout differentiation timelines, including cell viability, purity, and functional assessments
Maintain detailed documentation and data integrity across all experimental procedures
Perform molecular biology assays including qPCR, digital PCR, and protein quantification methods
A highly skilled laboratory scientist with 2+ years of specialized experience in iPSC-derived neuronal differentiation
Demonstrated expertise with stem cell differentiation protocols
Experience with single-cell RNA sequencing workflows
Proficiency in FACS operation, analysis, and troubleshooting
Proficiency in immunohistochemistry and fluorescence microscopy
Exceptional attention to detail with a track record of maintaining rigorous experimental standards
Proven ability to develop, document, and consistently follow detailed experimental protocols
Has a methodical approach to laboratory work with zero tolerance for procedural deviations
Preferred qualifications
Experience with electrophysiological characterization of differentiated neurons
Proficiency in confocal microscopy and automated image analysis for neuronal morphology assessment
Knowledge of neuronal subtype-specific markers and functional validation approaches
Experience with organoid development and 3D neuronal culture systems
Demonstrated track record of contributing to SOP development and laboratory standardization efforts
Compensation The base salary range for this full-time position is $90,000-$115,00 annually + equity + benefits. Within the range, individual pay is determined by several factors, including job-related skills, experience, and relevant education or training. Please keep in mind that the equity portion of the offer is not included in these numbers.
Benefits
Competitive salary and equity
Medical, dental, vision and life insurance
Flexible vacation and company-paid holidays
Healthy meals and snacks provided for non-remote employees
Paid parental, jury duty, bereavement, family care and medical leave
Flexible Spending Account and Dependent Care Flexible Spending Account
Childcare subsidy by Science
401(k)
Science Corporation is an equal opportunity employer. We strive to create a supportive and inclusive workplace where contributions are valued and celebrated, and our employees thrive by being themselves and are inspired to do their best work.
Equal opportunity and non-discrimination We seek applicants of all backgrounds and identities, across race, color, ethnicity, national origin or ancestry, citizenship, religion, sex, sexual orientation, gender identity or expression, veteran status, marital status, pregnancy or parental status, or disability. Applicants will not be discriminated against based on these or other protected categories or social identities. Science will also consider for employment qualified applicants with criminal histories in a manner consistent with applicable federal, state and local laws.
#J-18808-Ljbffr
Join our team of scientists and engineers as we develop next-generation cell and gene therapies for brain-computer interfaces and optogenetic vision restoration. You'll contribute directly to pioneering research with the potential to restore sight to the blind and create revolutionary neural interfaces. This is a perfect opportunity for a scientist to apply their expertise in neuronal differentiation in a fast-paced research environment focused on therapeutic applications.
Role responsibilities
Execute highly reproducible iPSC differentiation protocols to generate defined neuronal subtypes, with particular expertise in cortical neurons, inhibitory interneurons, and dopaminergic neurons
Develop, optimize, and rigorously adhere to detailed Standard Operating Procedures (SOPs) for all neuronal differentiation workflows
Perform single-cell RNA sequencing (sc-RNAseq) sample preparation, library construction, and quality control analysis
Execute advanced FACS sorting and analysis for neuronal population characterization and purification
Conduct comprehensive immunohistochemistry (IHC) and immunocytochemistry protocols for neuronal marker validation
Implement rigorous quality control assays throughout differentiation timelines, including cell viability, purity, and functional assessments
Maintain detailed documentation and data integrity across all experimental procedures
Perform molecular biology assays including qPCR, digital PCR, and protein quantification methods
A highly skilled laboratory scientist with 2+ years of specialized experience in iPSC-derived neuronal differentiation
Demonstrated expertise with stem cell differentiation protocols
Experience with single-cell RNA sequencing workflows
Proficiency in FACS operation, analysis, and troubleshooting
Proficiency in immunohistochemistry and fluorescence microscopy
Exceptional attention to detail with a track record of maintaining rigorous experimental standards
Proven ability to develop, document, and consistently follow detailed experimental protocols
Has a methodical approach to laboratory work with zero tolerance for procedural deviations
Preferred qualifications
Experience with electrophysiological characterization of differentiated neurons
Proficiency in confocal microscopy and automated image analysis for neuronal morphology assessment
Knowledge of neuronal subtype-specific markers and functional validation approaches
Experience with organoid development and 3D neuronal culture systems
Demonstrated track record of contributing to SOP development and laboratory standardization efforts
Compensation The base salary range for this full-time position is $90,000-$115,00 annually + equity + benefits. Within the range, individual pay is determined by several factors, including job-related skills, experience, and relevant education or training. Please keep in mind that the equity portion of the offer is not included in these numbers.
Benefits
Competitive salary and equity
Medical, dental, vision and life insurance
Flexible vacation and company-paid holidays
Healthy meals and snacks provided for non-remote employees
Paid parental, jury duty, bereavement, family care and medical leave
Flexible Spending Account and Dependent Care Flexible Spending Account
Childcare subsidy by Science
401(k)
Science Corporation is an equal opportunity employer. We strive to create a supportive and inclusive workplace where contributions are valued and celebrated, and our employees thrive by being themselves and are inspired to do their best work.
Equal opportunity and non-discrimination We seek applicants of all backgrounds and identities, across race, color, ethnicity, national origin or ancestry, citizenship, religion, sex, sexual orientation, gender identity or expression, veteran status, marital status, pregnancy or parental status, or disability. Applicants will not be discriminated against based on these or other protected categories or social identities. Science will also consider for employment qualified applicants with criminal histories in a manner consistent with applicable federal, state and local laws.
#J-18808-Ljbffr