PhD position

CHARMM is a versatile program for atomic-level simulation of many-particle systems, particularly macromolecules of biological interest. - M. Karplus The Han Lab at the University of North Texas Denton is seeking multiple PhD students to contribute to interdisciplinary research at the interface of molecular biophysics, hormone signaling, and therapeutic design. The primary focus of the lab is on G protein-coupled receptors (GPCRs), particularly those involved in cardiovascular and hormone signaling pathways. Using multiscale simulations—combining molecular dynamics, enhanced sampling, and kinetic modeling—the team investigates how neurotransmitters like norepinephrine and hormones such as estrogen interact with β-adrenergic and estrogen-related GPCRs. These studies aim to uncover the molecular basis of GPCR cross-talk and its impact on sex-specific cardiovascular function and disease. The lab is also interested in AI-driven design of peptides and proteins for therapeutic applications. This includes previously developed novel peptide drugs inspired by natural toxins to selectively target ion channels, as well as engineering antimicrobial peptides using machine learning and structural modeling approaches. This position offers an exciting opportunity to work on the mechanistic study of GPCR-mediated signaling, the rational design of next-generation biologics for precision medicine, and beyond. How to Apply

Please send CV to Yanxiao.Han@unt.edu

The official deadline for application through the school system is on August 1 2025 for the spring admission in 2026.

Please see the information here:https://biology.unt.edu/graduate-programs/index.html

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