International Executive Service Corps
Bacterial Core Lead Scientist
International Executive Service Corps, Frederick, Maryland, United States, 21701
Overview
The Alaka`ina Foundation Family of Companies (FOCs) has a potential need for a
Bacterial Core Lead Scientist
to support our government customer located in Frederick, MD at Fort Detrick. Responsibilities
Use computer to analyze data and prepare graphs, do statistics, write lab notes and reports. Complete quarterly reports and annual progress reports per investigator. Present 2 research findings/presentations at lab meetings and participate in approximately 23 lab meetings per year; attend approximately 2 scientific meetings or symposia (CONUS or OCONUS) if required. Attend 12 division meetings per year and give 1 presentation per investigator. Prepare one first-author manuscript for publication per year. Prepare approximately 2 supporting-author scientific papers for publication. Maintain ~6 microscope systems in laboratories and be responsible for ordering microscopy systems and parts. Prepare BSL-2 and BSL-3 labs for safety, bio-surety and CDC inspections. Plan and perform in vitro minimum inhibition concentration (MIC) testing or potential therapeutic compounds against tier 1 bacteria, currently utilizing 30-strain diversity sets of Bacillus anthracis (anthrax), Yersinia pestis (plague), Francisella tularensis (tularemia), Burkholderia mallei (glanders), and Burkholderia pseudomallei (melioidosis), testing over 72 compounds per year against all 30 strains, in vitro. Plan and participate in mouse, rat, and rabbit studies, including preparation of antibiotics for administration, administering drugs and vaccines, orally and by various routes; collect animal body fluids and tissues as part of small-animal studies; ensure study compliance with IACUC-approved protocols. Participate in weekly lab meetings and assist in development and design with current and future in vitro and in vivo work; may be requested to present posters at scientific conferences which may require work outside normal business hours. Plan and participate in small-animal BSL-2 pharmacokinetics and toxicology studies, including preparation of antibiotics, administration, and sample collection for PK/PD analysis. Support the in vivo pharmacology research program and contribute to the multidisciplinary team to determine pharmacokinetics and pharmacodynamics relationships and efficacy of optimized leads. Assist in animal protocols working with bacterial pathogens and participate in testing and purifying Bacillus anthracis components for efficacy studies. Write, plan and execute animal protocols. Perform ELISAs and process flow cytometry samples; test for endotoxin and perform endotoxin remediation when necessary. Purify bacterial products from culture supernatants; conduct equipment inventory management twice a year in BSL-2 and BSL-3 labs. Perform monthly laboratory management tasks including safety functions and chemical inventory; provide a monthly scientific support report with materials/methods, data and data analysis updates. Maintain a GLP training folder and be compliant with GLP regulations when applicable. Other duties as assigned. Required Degree/Education/Certification
Masters Degree in a biological or life science and 7 years of experience (preferred). Bachelor's degree and 5 years’ experience. Required Skills and Experience
Experience in high performance liquid chromatography coupled to mass spectrometry (HPLC-MS). Experience in animal manipulations. Experience with in vitro antibiotic susceptibility assay systems and pharmacokinetic (PK) determinations on antibiotics from various animal species. Knowledge of animal study design, including developing therapeutic treatment plans, dosing schedules, number of animals required, supplies, and facilities needed for given study endpoints. Familiarity with high performance liquid chromatography (HPLC), mass spectroscopy (MS), minimum inhibitory concentration (MIC), and other antibiotic determination methods from animal serum and tissues. Experience operating an HPLC/Mass Spec instrument, including development of qualitative and quantitative assays for various antibiotic classes. Ability to prepare biological samples for antibiotic assays and prepare reagents/solvents for HPLC separations. Citizenship and Clearance
U.S. Citizen Must pass background check. Must be willing to work in a BSL-3 laboratory. Must be eligible to enroll in required government programs. The Alaka`ina Foundation Family of Companies (FOCs) is a fast-growing government service provider. Employees enjoy competitive salaries. Eligible full-time employees receive benefits including a 401K with company match, medical, dental, disability and life insurance, tuition reimbursement, paid time off, and paid holidays. We are an Equal Opportunity/Affirmative Action Employer of individuals with disabilities and veterans. If you need an accommodation during the application process, please request accommodation. We verify all employees per applicable laws.
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The Alaka`ina Foundation Family of Companies (FOCs) has a potential need for a
Bacterial Core Lead Scientist
to support our government customer located in Frederick, MD at Fort Detrick. Responsibilities
Use computer to analyze data and prepare graphs, do statistics, write lab notes and reports. Complete quarterly reports and annual progress reports per investigator. Present 2 research findings/presentations at lab meetings and participate in approximately 23 lab meetings per year; attend approximately 2 scientific meetings or symposia (CONUS or OCONUS) if required. Attend 12 division meetings per year and give 1 presentation per investigator. Prepare one first-author manuscript for publication per year. Prepare approximately 2 supporting-author scientific papers for publication. Maintain ~6 microscope systems in laboratories and be responsible for ordering microscopy systems and parts. Prepare BSL-2 and BSL-3 labs for safety, bio-surety and CDC inspections. Plan and perform in vitro minimum inhibition concentration (MIC) testing or potential therapeutic compounds against tier 1 bacteria, currently utilizing 30-strain diversity sets of Bacillus anthracis (anthrax), Yersinia pestis (plague), Francisella tularensis (tularemia), Burkholderia mallei (glanders), and Burkholderia pseudomallei (melioidosis), testing over 72 compounds per year against all 30 strains, in vitro. Plan and participate in mouse, rat, and rabbit studies, including preparation of antibiotics for administration, administering drugs and vaccines, orally and by various routes; collect animal body fluids and tissues as part of small-animal studies; ensure study compliance with IACUC-approved protocols. Participate in weekly lab meetings and assist in development and design with current and future in vitro and in vivo work; may be requested to present posters at scientific conferences which may require work outside normal business hours. Plan and participate in small-animal BSL-2 pharmacokinetics and toxicology studies, including preparation of antibiotics, administration, and sample collection for PK/PD analysis. Support the in vivo pharmacology research program and contribute to the multidisciplinary team to determine pharmacokinetics and pharmacodynamics relationships and efficacy of optimized leads. Assist in animal protocols working with bacterial pathogens and participate in testing and purifying Bacillus anthracis components for efficacy studies. Write, plan and execute animal protocols. Perform ELISAs and process flow cytometry samples; test for endotoxin and perform endotoxin remediation when necessary. Purify bacterial products from culture supernatants; conduct equipment inventory management twice a year in BSL-2 and BSL-3 labs. Perform monthly laboratory management tasks including safety functions and chemical inventory; provide a monthly scientific support report with materials/methods, data and data analysis updates. Maintain a GLP training folder and be compliant with GLP regulations when applicable. Other duties as assigned. Required Degree/Education/Certification
Masters Degree in a biological or life science and 7 years of experience (preferred). Bachelor's degree and 5 years’ experience. Required Skills and Experience
Experience in high performance liquid chromatography coupled to mass spectrometry (HPLC-MS). Experience in animal manipulations. Experience with in vitro antibiotic susceptibility assay systems and pharmacokinetic (PK) determinations on antibiotics from various animal species. Knowledge of animal study design, including developing therapeutic treatment plans, dosing schedules, number of animals required, supplies, and facilities needed for given study endpoints. Familiarity with high performance liquid chromatography (HPLC), mass spectroscopy (MS), minimum inhibitory concentration (MIC), and other antibiotic determination methods from animal serum and tissues. Experience operating an HPLC/Mass Spec instrument, including development of qualitative and quantitative assays for various antibiotic classes. Ability to prepare biological samples for antibiotic assays and prepare reagents/solvents for HPLC separations. Citizenship and Clearance
U.S. Citizen Must pass background check. Must be willing to work in a BSL-3 laboratory. Must be eligible to enroll in required government programs. The Alaka`ina Foundation Family of Companies (FOCs) is a fast-growing government service provider. Employees enjoy competitive salaries. Eligible full-time employees receive benefits including a 401K with company match, medical, dental, disability and life insurance, tuition reimbursement, paid time off, and paid holidays. We are an Equal Opportunity/Affirmative Action Employer of individuals with disabilities and veterans. If you need an accommodation during the application process, please request accommodation. We verify all employees per applicable laws.
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